检索结果-南通市图书馆

urosepsis among Sudanese Patients: A Paradigm from Limited Resources Country

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in Microbiology 2022年第3期12卷 109-120页

作者： Salma Omer Ibrahim Mohammed Elimam Sami Mahjoub Taha Sanaa Mohammed Yousif Hajir Mohammed Hussein Omer Mirghani Yousif Seitelbanat Yassin Ali Elnaiem Yousif Abdelhameed Mohammed Omer Abu Elhasan Adama Dawoud Abakar Elhadi Abdalla Ahmed Department of Medical Microbiology Faculty of Medical Lab Sciences University of Gezira Wad Medani Sudan Faculty of Medicine University of Gezira Wad Medani Sudan National Blood Bank Ministry of Health Khartoum Sudan Clinical Pharmacy and Pharmacy Practice Faculty of Pharmacy University of Gezira Wad Medani Sudan Department of Pharmaceutics Faculty of Pharmacy University of Gezira Wad Medani Sudan Resident at Gezira Hospital for Renal Disease and Surgery Urology (GHRDS) Wad Medani Sudan Cancer National Institute University of Gezira Wad Medani Sudan Wad Madani College for Medical Science and Technology Wad Medani Sudan Department of Medical Parasitology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan

Background: urosepsis is life-threatening sepsis that leads to organ dysfunction and results from a defective response to a urinary tract infection;the major precipitating is obstructive uropathy in the upper or lower urinary tract (UT). The magnitude and burden of bacteria that caused uropathy were reported to increase annually. In 30% of all septic patients who were diagnosed with urosepsis, 1.5% of them were found in urology and a quarter due to hospital-acquired urinary tract infections (HAUTIs). This study aims to determine the clinical pattern and the frequency of commonly used antibiotics against bacteria associated with urosepsis among Sudanese patients. Methods: This was a cross sectional laboratory-based study, study subjects were recruited from patients attended to Gezira Hospital for Renal diseases and surgery (GHRDS) and was diagnosed, on clinical and laboratory basis, to have urosepsis. Hundred (n = 100) urine samples were collected and inoculated on cysteine lactose electrolyte deficient agar (CLED) media and identify using the suitable biochemical test and performed antimicrobial susceptibility testing (AST) by Kirby Bauer disc diffusion technique for selected antimicrobial agents, according to clinical laboratory standard institute (CLSI) guidelines. Results: Amongst urosepsis infection the frequency of E. coli, S. aureus, Proteus mirabilis, Klebseilla pneumonia and Pseudomonas aeruginosa were (37%, 21%, 10%, 6%, 4% respectively). Resistance to commonly prescribed antibiotics was high, ranging from 17% for meropenem to 100% for cefepime. P. aeruginosa was multidrug resistant compared with other isolates. Conclusions: There was high rate of antibiotic resistance against the common causes of urosepsis in GHRDS, and this reflects the importance of culture and sensitivity test and necessitates adoption of guidelines for selection of suitable antibiotic.

关键词： urosepsis Antimicrobial Susceptibility Gezira Hospital for Renal Diseases and Surgery Sudan

Comparative Study of urosepsis-Associated Escherichia coli in Tertiary Care University Hospital in the Central Region of Japan from 2008 to 2011

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2016年第6期4卷 18-23页

作者： Masaaki Minami Naoki Wakiyama Minoru Ohhashi Yukio Wakimoto Michio Ohta Department of Bacteriology Graduate School of Medical Sciences Nagoya City University Nagoya Japan Department of Clinical Investigation Nagoya City University Hospital Nagoya Japan School of Nursing Sugiyama Jyogakuen University Nagoya Japan

Escherichia coli infection is important cause of morbidity and mortality. urosepsis is most commonly caused by Escherichia coli. It is generally reported to have low mortality rates and favorable outcomes compared with sepsis induced in other organ/ system or tissues. This study was conducted to find out the clinical characteristics of urosepsis-associated Escherichia coli isolates at tertiary care university hospital in the central region of Japan from 2008 to 2011. Escherichia coli was identified by standard laboratory procedure. Antimicrobial susceptibility testing was performed by micro dilution assay according to CLSI recommendation. We analyzed the relationship between medical records appended to clinical species and bacterial data by using a statistical method. Of one hundred five Escherichia coli, fifty-three were from urosepsis and fifty-two were from other disease. The ratio of male to female from urosepsis tended to be lower than that from others. Forty-two isolates were from outpatient and sixty-three were from inpatient. The ratio of inpatient to outpatient from urosepsis was significant lower than that from others. With respect to age, the numbers of elder patients were higher than those of others. Most of the Escherichia coli isolates were from the emergency room followed by urology, and general medicine. The ratio of urosepsis to no urosepsis at urology department was significant higher than that at other departments. With respect to antimicrobial susceptible pattern, the ratio of urosepsis to no urosepsis about only aztreonam resistant was significant higher than that about other antibiotics. We need enough attention to be paid to urosepsis, especially female and elder patients.

关键词： Escherichia coli urosepsis Antimicrobial Resistance Susceptibility Epidemiology

Differential protein expression in patients with urosepsis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Traumatology 2018年第6期21卷 316-322页

作者： Xu-Kai Yang Nan Wang Cheng Yang Yang-Min Wang Tuan-Jie Che Department of Urology Lanzhou General Hospital PLALanzhou 730050China Department of Infection Xi'an Central HospitalXi'an 710033China Student teams Basic Medical CollegeThe Fourth Military Medical UniversityXi'an710032 China Lanzhou Baiyuan Gene Technology Co.Ltd Lanzhou 730000China

Purpose:urosepsis in adults comprises approximately 25% of all sepsis cases, and is due to complicated urinary tract infections in most cases. However, its mechanism is not fully clarified. urosepsis is a very complicated disease with no effective strategy for early diagnosis and treatment. This study aimed to identify possible target-related proteins involved in urosepsis using proteomics and establish possible networks using ***:Fifty patients admitted to the Urology Unit of Lanzhou General PLA (Lanzhou, China), from October 2012 to October 2015, were enrolled in this study. The patients were further divided into shock and matched-pair non-shock groups. 2-DE technique, mass spectrometry and database search were used to detect differentially expressed proteins in serum from the two ***:Six proteins were found at higher levels in the shock group compared with non-shock individuals, including serum amyloid A-1 protein (SAA1), apolipoprotein L1 (APOL1), ceruloplasmin (CP), haptoglobin (HP), antithrombin-III (SERPINC1) and prothrombin (F2), while three proteins showed lower levels, including serotransferrin (TF), transthyretin (TTR) and alpha-2-macroglobulin (A2M).Conclusion:Nine proteins were differentially expressed between uroseptic patients (non-shock groups) and severe uroseptic patients (shock groups), compared with non-shock groups, serum SAA1, APOL1,CP, HP, SERPINC1 and F2 at higher levels, while TF, TTR and A2M at lower levels in shock *** proteins were mainly involved in platelet activation, signaling and aggregation, acute phase protein pathway, lipid homeostasis, and iron ion transport, deserve further research as potential candidates for early diagnosis and treatment. (The conclusion seems too simple and vague, please re-write it. You may focus at what proteins have been expressed and introduce more detail about its significance.)

关键词： Protein expression urosepsis Proteomics

Value of urine IL-8, NGAL and KIM-1 for the early diagnosis of acute kidney injury in patients with ureteroscopic lithotripsy related urosepsis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Traumatology 2022年第1期25卷 27-31页

作者： Dan Tan Liang Zhao Wei Peng Fang-Hao Wu Guo-Bin Zhang Bo Yang Wen-Qian Huo Department of Urology The General Hospital of Chongqing Steel CompanyChongqing400081China

Purpose::To investigate the clinical value of urine interleukin-18(IL-8),neutrophil gelatinase-associated lipocalin(NGAL)and kidney injury molecule-1(KIM-1)for the early diagnosis of acute kidney injury(AKI)in patients with ureteroscopic lithotripsy(URL)related ***::A retrospective study was carried out in 157 patients with urosepsis after *** patients were divided into AKI group and non-AKI group according to the Kidigo guideline and urine IL-8,NGAL and KIM-1 levels were detected by enzyme-linked immunosorbent assay at 0,4,12,24 and 48 h after the *** operating characteristic curve(ROC)was used to evaluate the diagnostic value of these three biomarkers for postoperative ***::The level of urine IL-8,NGAL and KIM-1 in AKI group was significantly higher than that in non-AKI group at 4,12,24 and 48 h(p<0.01).The ROC analysis showed the combined detection of urine IL-8,NGAL and KIM-1 at 12 h had a larger area under curve(AUC)than a single marker(0.997,95%CI:0.991-0.998),and the sensitivity and specificity were 98.2%and 96.7%,*** correlation analysis showed that the levels of urine NGAL at 4,12,24 and 48 h in AKI patients were positively correlated with the levels of urine KIM-1 and IL-18(p<0.01).Conclusion::AKI could be quickly recognized by the elevated level of urine IL-8,NGAL and KIM-1 in patients with URL-related *** detection of the three urine biomarkers at 12 h after surgery had a better diagnostic performance,which may be an important reference for the early diagnosis of AKI.

关键词： urosepsis Ureteroscopic lithotripsy Acute kidney injury Early diagnosis lnterleukin-18 Neutrophil gelatinase-associated lipocalin Kidney injury molecule-1

Incidence of Oxa23 and Oxa51 Genes Associated with Bacterial Isolated from Patients with urosepsis: Single Centre Prespective

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

American Journal of Molecular Biology 2022年第3期12卷 85-96页

作者： Salma Omer Ibrahim Elimam M. A. Mohammed Sami Mahjoub Taha Sanaa Mohammed Yousif Hajir Omer Omer Omer Mirghani Seif-Elnasr Seitelbanat Yassin Yousif Abdelhameed Mohammed Omer Abu Elhasan Mohamed Taj-Eldin Adam Dawoud Abakar Elhadi Abdalla Ahmed Salaheldein G. Elzaki Department of Medical Microbiology Faculty of Medical Lab Sciences University of Gezira Wad Medani Sudan Department of Urology Faculty of Medicine University of Gezira Wad Medani Sudan National Blood Bank Ministry of Health Khartoum Sudan University Hospital Galway Galway Ireland Department of Urology Gezira Hospital for Renal Disease and Surgery Wad Medani Sudan Department of Pharmaceutics Faculty of Pharmacy University of Gezira Wad Medani Sudan Department of Clinical Chemistry National Cancer Institute University of Gezira Wad Medani Sudan Department of Medical Microbiology Wad Medani College for Medical Science and Technology Wad Medani Sudan Department of Medical Parasitology Faculty of Medical Laboratory Sciences University of Gezira Wad Medani Sudan Department of Epidemiology Tropical Medicine Research Institute Khartoum Sudan

Background: urosepsis is one of the most common infections that require empirical broad spectrum antibiotics immediately after diagnosis. This has led to development of bacterial resistance by acquiring the capability to destroy the β-lactam ring. Methodology: This is a cross-sectional hospital-based study. The study was conducted from 2019 to 2020 at Gezira Hospital for Renal diseases and surgery (GHRDS). A hundred patients were diagnosed clinically with urosepsis and the isolated organisms were Escherichia coli, Staphylococcus aureus, Proteus mirabilis, Klebsiella pneumonia and Pseudomonas aeruginosa. The susceptibility test was conducted by Kirby Bauer disc diffusion technique according to clinical laboratory standard institute (CLSI) guidelines. Seventy eight samples of bacterial genomic DNA were confirmed by 16srRNA and multiplex PCR, were performed for genotypic blaOXA-51 and blaOXA-23 gene characterization of isolated bacteria. Then gel electrophoresis was used to identify the presence or absence of (blaOXA-51 and blaOXA-23) genes. Results: 88.5% (69/78) in 16srRNA detected. Using multiplex PCR, the frequencies of blaOXA-51 and blaOXA-23 genes were 13% and 10.1%, respectively. The percentages of isolates which yielded both blaOXA-51 and blaOXA-23 among P. aeruginosa was 25% (1/4), among K. pneumonia was 17% (1/6), and among E. coli was 8% (3/37). Only blaOXA-51 was detected in P. mirabilis 10% (1/10) and only blaOXA-23 was detected in S. aureus 5% (1/18). Conclusion: In this study, the presence of blaOXA-51 and blaOXA-23 genes was increased in the isolated bacteria.

关键词： urosepsis Carbapenem-Resistant Enterobacteriaceae (CRE) blaOXA-51 and blaOXA-23

Fatal urosepsis: A 41 Year-Old Pregnant Woman—Case Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Urology 2014年第11期4卷 137-141页

作者： Malgorzata Gosciniak Dariusz Kawecki Malgorzata Miklaszewska Zenon Truszewski Tomasz Lazowski Miroslaw Wielgos Piotr Radziszewski Department of Emergency Medicine Medical University of Warsaw Warsaw Poland Department of Medical Microbiology Warsaw Medical University Warsaw Poland Department of Intensive Care Medical University of Warsaw Warsaw Poland Department of Obstetrics and Gynecology Medical University of Warsaw Warsaw Poland Department of General Oncologic and Functional Urology Medical University of Warsaw Warsaw Poland

Introduction: Urinary tract infections are one of the most frequent infectious complications during pregnancy [1], while acute pyelonephritis is the main non-obstetric reason for hospitalisation [2] [3]and septic shock in pregnant women. Objectives and methods: The aim of our study is to analyse the diagnostics and treatment of a 41-year-old pregnant woman with the most severe form of urinary tract infection—urosepsis. Case report: A 41-year old woman in the 12th week of pregnancy hospitalised at Intensive Care Unit (ICU) after urological intervention (JJ stent). On the first day after the intervention, the patient was diagnosed as having urosepsis. Scores: SOFA 14 pts, APACHE II 26 pts, SAPS II SCORE 61 pts. Second day in ICU: spontaneous abortion. Microbiological?investigation: Escherichia coli—extended-spectrum beta-lactamase (ESBL+). Conclusions: Apregnant patient with a complicated infection of the urinary system ought to be treated in a multi-profile hospital, offering a possibility to consult doctors of various specialisations (urologist, gynaecologist, anaesthesiologist, nephrologist) as well as full access to a radiology laboratory, which will ensure the choice of appropriate and safe treatment for both the mother and the developing foetus.

关键词： Pregnancy urosepsis Nephrolithiasis Ureteroscopy

Sepsis associated delirium mimicking postoperative delirium as the initial presenting symptom of urosepsis in a patient who underwent nephrolithotomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2016年第5期4卷 130-134页

作者： Deb Sanjay Nag Abhishek Chatterjee Devi Prasad Samaddar Harprit Singh Department of Anaes-thes-iology and Critical Care Tata Main Hos-pital Department of Urology Tata Main Hos-pital

We report a case of 70 years old male who underwent percutaneous nephrolithotomy for renal *** an uneventful recovery from anaesthesia,the patient developed delirium which manifested as restlessness,agitation,irritability and combative *** other clinical parameters including arterial blood gas,chest X-ray and core temperature were normal and the patient remained haemodynamically *** 45 min later the patient developed florid manifestations of septic *** was aggressively managed in a protocolized manner as per the Surviving Sepsis Guidelines in the Critical Care Unit and recovered *** are no case reports showing postoperative delirium as the only initial presentation of severe sepsis,with other clinical parameters remaining *** urosepsis and sepsis associated delirium have very high *** index of suspicion and a protocolized approach in the management of sepsis can save lives.

关键词： urosepsis Nephrolithotomy Postoperative delirium Sepsis associated delirium Delirium

Disseminated osteomyelitis after urinary tract infection in immunocompetent adult:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第16期8卷 3542-3547页

作者： Young Jun Kim Jae Hoon Lee Department of Internal Medicine Institute of Wonkwang Medical ScienceWonkwang University College of MedicineIksan 54538South Korea

BACKGROUND Urinary tract infection(UTI)is one of the most common bacterial *** pyelonephritis or upper urinary tract infection is often accompanied by bacteremia;however,bacteremia resolves in most cases without ***,complications due to bacteremia *** of these is *** mainly affects the lumbar vertebral bodies,and rarely affects other *** SUMMARY An 80-year-old woman presented to the hospital with a two-month history of pain in both *** months ago,she was admitted to the hospital for fever,flank pain,and urinary frequency and was diagnosed with bacteremic *** hospitalization,she complained of pain in both legs;however,the pain resolved shortly after,and no abnormalities were observed on physical ***,she was placed on 2-wk antibiotic therapy for UTI without further evaluation for leg ***,pain recurred after discharge and persisted;therefore,an imaging test was *** scan and magnetic resonance imaging suggested osseous infection in both femurs,tibiae and *** treatment was performed,and tissue-and bone cultures revealed Escherichia coli,a previously observed pathogen,which demonstrated same antibiotic sensitivities,as noted in previous *** was diagnosed with disseminated osteomyelitis,as a complication of UTI,and was placed on an 8-wk antibiotic *** Indication for osteomyelitis should be high regardless of bone pain at sites other than lumbar spine after or during UTI.

关键词： Urinary tract infection urosepsis Complication Disseminated Osteomyelitis Escherichia coli Case report

A case of follicular cystitis treated successfully with diethylcarbamazine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Urology 2021年第2期8卷 235-237页

作者： Maduwe Gedara Sagara Ruwan Kumara Prasanga Thiranagama Cherine Sosai Anuruddha Abeygunasekera Department of Urology Colombo South Teaching HospitalDehiwalaSri Lanka Department of Pathology Colombo South Teaching HospitalDehiwalaSri Lanka

Follicular cystitis is a non-specific inflammatory condition of the bladder where the aetiology is *** extent of the disease can be mild or proliferative and ***,steroids,therapies used for interstitial cystitis,palliative cystectomy and radiotherapy have been reported as successful treatment *** report a case of follicular cystitis that responded to a course of oral diethyl carbamazine.

关键词： Chronic cystitis Pyuria Bladder pathology urosepsis