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The Utility of Voided urine Samples as a Proxy for the Vaginal microbiome and for the Prediction of Bacterial Vaginosis

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Infectious Microbes & Diseases 2022年第4期4卷 149-156页

作者： Bin Zhu Christopher Diachok Laahirie Edupuganti David J.Edwards Jeffrey R.Donowitz Katherine Tossas Andrey Matveyev Katherine M.Spaine Vladimir Lee Myrna G.Serrano Gregory A.Buck Department of Microbiology and Immunology School of MedicineVirginia Commonwealth UniversityRichmondVirginiaUSA Center for microbiome Engineering and Data Analysis Virginia Commonwealth UniversityRichmondVirginiaUSA Department of Statistical Sciences and Operations Research College of Humanities and SciencesVirginia Commonwealth UniversityRichmondVirginiaUSA Department of Pediatric Infectious Diseases Children's Hospital of Richmond at Virginia Commonwealth UniversityRichmondVirginiaUSA Department of Infectious Diseases and International Health University of VirginiaCharlottesvilleVirginiaUSA Department of Health Behavior and Policy School of MedicineVirginia Commonwealth UniversityRichmondVirginiaUSA Department of Family Medicine and Population Health School of MedicineVirginia Commonwealth UniversityRichmondVirginiaUSA Computer Science Department College of EngineeringVirginia Commonwealth UniversityRichmondVirginiaUSA Genomics Core Virginia Commonwealth UniversityRichmondVirginiaUSA

Recent work has shown that the vaginal microbiome exerts a strong impact on women's gynecological ***,collection of vaginal specimens is invasive and requires previous clinical training or the involvement of a trained *** contrast,urine sample collection is routine and noninvasive and does not require involvement of a *** sought to compare the vaginal and urogenital microbiomes to assess the utility of voided urine samples as a proxy for the vaginal *** urogenital and vaginal samples were collected from pregnant women and characterized by 16S rRNA taxonomic *** examined diversities and compositions of paired urogenital and vaginal microbiomes using five discrete strategies to explore the similarity between the vaginal and urogenital microbiomes.A strategy comparing the paired urogenital and vaginal microbiomes in which taxa were assigned using the STIRRUPS database and urine-specific taxa were removed showed no significant difference in diversity and composition between the paired urogenital and vaginal ***,the relative abundances of common vaginal taxa were linearly correlated with those in the paired *** similarities suggest that voided urine samples could represent a noninvasive protocol for accurate profiling of the vaginalmicrobiome with likely clinical ***,a machine learning model was established in which the voided urine microbiome was compared favorably to the vaginal microbiome in predicting bacterial vaginosis.

关键词： 16S rRNA vaginal microbiome urine microbiome bacterial vaginosis reproductive and gynecologic health

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