检索结果-南通市图书馆

Plasma Metabonomics of Human Adenovirus-infected Patients with Pneumonia and upper respiratory tract infection

Current Medical Science 2024年第1期44卷 121-133页

作者： Ting-ting WEI Wen XU Bo TU Wan-xue ZHANG Xin-xin YANG Yiguo ZHOU Shan-shan ZHANG Jun-lian YANG Ming-zhu XIE Juan DU Wei-wei CHEN Qing-bin LU Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Infectious Disease The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Department of Laboratorial Science and Technology&Vaccine Research Center School of Public HealthPeking UniversityBeijing 100191China Department of Health Policy and Management School of Public HealthPeking UniversityBeijing 100191China Global Center for Infectious Disease and Policy Research&Global Health and Infectious Diseases Group Peking UniversityBeijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijing 100191China

Objective Human adenovirus(HAdV)infection is common and can develop to serious conditions with high mortality,yet the mechanism of HAdV infection remains unclear.In the present study,the serum metabolite profiles of HAdV-7-infected patients with pneumonia or upper respiratory tract infection(URTI)were explored.Methods In total,35 patients were enrolled in the study following an outbreak of HAdV-7 in the army,of whom 14 had pneumonia and 21 had URTI.Blood samples were collected at the acute stage and at the recovery stage and were analyzed by untargeted metabolomics.Results Over 90% of the differential metabolites identified between the pneumonia patients and URTI patients were lipids and lipid-like molecules,including glycerophospholipids,fatty acyls,and sphingolipids.The metabolic pathways that were significantly enriched were primarily the lipid metabolism pathways,including sphingolipid metabolism,glycerophospholipid metabolism,and linoleic acid metabolism.The sphingolipid metabolism was identified as a significantly differential pathway between the pneumonia patients and URTI patients and between the acute and recovery stages for the pneumonia patients,but not between the acute and recovery stages for the URTI patients.Ceramide and lactosylceramide,involved in sphingolipid metabolism,were significantly higher in the pneumonia patients than in the URTI patients with good discrimination abilities[area under curve(AUC)0.742 and 0.716,respectively;combination AUC 0.801].Conclusion Our results suggested that HAdV modulated lipid metabolism for both the patients with URTI and pneumonia,especially the sphingolipid metabolism involving ceramide and lactosylceramide,which might thus be a potential intervention target in the treatment of HAdV infection.

关键词： human adenovirus metabonomic lipids pneumonia upper respiratory tract infection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of gastrointestinal heat retention syndrome on gut microbiota in children with upper respiratory tract infection and lung-heat syndrome

引用

Journal of Traditional Chinese Medical Sciences 2022年第1期9卷 13-21页

作者： Shuangcheng Wang Xueyan Ma Liqun Wu He Yu Yanran Shan Yuanshuo Tian Tiegang Liu Xiaohong Gu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Department of Pediatrics Dongfang Hospital of Beijing University of Chinese MedicineBeijing100078China

Objective:Gastrointestinal heat retention syndrome(GHRS)is associated with lung-heat syndrome and is related to recurrent respiratory infection.upper respiratory tract infection(URTI)lung heat syndrome is common in children.The study will explore the effect of GHRS on the structure and function of gut microbiota in children with URTI lung-heat syndrome.Methods:Participants were divided into both groups using the self-developed URTI scale and the“GHRS Diagnostic Scale$Pediatric Part”:GHRS-positive children(LS group)and GHRS-negative children(L group).General information,clinical symptoms,and stool were collected.We used 16S rRNA amplicon sequencing technology to determine the gene sequence of the V3eV4 region in feces and measure the gut microbiota of the both groups at the genus level.Results:A total of 23 children were included in the both groups.There were 12 cases in the LS group and 11 cases in the L group.There was no statistical difference between the both groups in age,gender,height,weight,and body mass index.The effective sequences shared by the both groups accounted for 85.66%of the total.In the gut microbiota,there was no difference in the a diversity and the b diversity between the both groups.Compared with the L group,the LS group had a significant increase in the relative abundance of the Ruminococcus gnavus group,Prevotella-9,Staphylococcus,and Actinomyces(P<.05).The functions of the both groups of microbiota primarily concentrate on metabolism,genetic information processing,and environmental information processing.The relative abundance of signaling molecules and interactions in the LS group were higher than that in the L group(P<.05).The redundancy analysis(RDA)showed that the URTI score had the greatest impact on the distribution of microbiota.Conclusion:GHRS may affect the development of URTI lung-heat syndrome by changing the relative abundances of gut microbiota.

关键词： Gastrointestinal heat retention syndrome upper respiratory tract infection Gut microbiota Lung-heat syndrome Lung-stomach heat retention syndrome 16S rRNA gene sequencing Redundancy analysis Diversity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Effect of Comfort Nursing on the Compliance and Efficacy of Treatment for Children with Acute Otitis Media Caused by upper respiratory tract infection

引用

Journal of Clinical and Nursing Research 2023年第6期7卷 78-82页

作者： Jing Xu Jun Qian Nanjing Maternal and Child Health Care Hospital Nanjing 210000China

Objective:To explore and analyze the clinical effect of comfort nursing on children with acute otitis media.Methods:62 children with acute otitis media caused by upper respiratory tract infection who visited the outpatient clinic of our hospital from June 2022 to June 2023 were selected for this study.They were divided into a study group(n=31)and a control group(n=31).Children in the control group received basic care,while children in the study group received comfort nursing along with basic care.The hearing thresholds,body temperature,treatment compliance,and nursing satisfaction of the two groups of children were compared.Results:After the nursing intervention,the hearing threshold and average body temperature of the children in the study group were lower than those in the control group(Pupper respiratory tract infection.

关键词： Comfort nursing upper respiratory tract infection Acute otitis media

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of the Real-world Efficacy of Lianhua Qingwen Capsule(莲花清瘟胶囊)in the Treatment of upper respiratory tract infection

引用

World Journal of Integrated Traditional and Western Medicine 2021年第6期7卷 27-33页

作者：王馥丽孙梦华谢雁鸣李向杰 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China School of Statistics Renmin University of ChinaBeijing 100872China

Objective:To explore the efficacy of Lianhua Qingwen Capsule(莲花清瘟胶囊)on upper respiratory tract infection,to understand the impact of Lianhua Qingwen Capsule(莲花清瘟胶囊)on the treatment outcome of upper respiratory tract infection,and provide reference for rational clinical drug use.Methods:The HIS database based on 18 large third-grade class-A hospitals was selected to match 1:1 for upper respiratory tract infection patients using and without Lianhua Qingwen Capsule(莲花清瘟胶囊)according to certain standards.The recombination of treatment outcome as"recovery"and"improvement"in the database was defined as effective treatment,"ineffectiveness","death"and"other"as ineffectivetreatment populations,and the effectiveness of treatment outcomes in the remerged 2 groups was compared by propensity score method.Results:After matching,454 cases were in both the patients treated by(experimental group)and without(control group)Lianhua Qingwen Capsule(莲花清瘟胶囊).Analysis was performed by three Logistic regression methods,all showing regression coefficients greater than 0 and statistically significant differences(Pupper respiratory tract infection treated by Lianhua Qingwen Capsule(莲花清瘟胶囊)are more effective than that without Lianhua Qingwen Capsule(莲花清瘟胶囊),it can improve the clinical efficacy of patients with upper respiratory tract infection。

关键词： Tensity analysis Lianhua Qingwen Capsule(莲花清瘟胶囊) upper respiratory tract infection Real world

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical and Experimental Study on Shuanghua Aerosol (双花喷雾剂) in Treating Infantile upper respiratory tract infection

引用

Chinese Journal of Integrative Medicine 2001年第2期7卷 82-85页

作者：马丙祥段晓颖王志超翟文生王又红马玉宏潘灏白 The First Affiliated Hospital of Henan College of TCM

Objective: To study the effect and mechanism of Shuanghua aerosol (SHA) in treating infantile upper respiratory tract infection. Methods: In the clinical study, 276 patients were randomly divided into two groups. The treated group was treated with SHA and the control group was treated with Shuanghuanglian aerosol (SHLA, 双黄连气雾剂). In the experimental study, the effects of SHA on anti-inflammation and anti-virus were observed. Results: The clinical total effective rate of SHA was 99.03% and its cure rate 65.38%, while those of the SHLA were 94.11% and 44.12% respectively, significant difference was shown between the two groups (Pupper respiratory tract infection.

关键词： Shuanghua aerosol upper respiratory tract infection external invaded Wind-Heat Syndrome anti-viral effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Jiuwei Zhuhuang Powder on Cough Resolution in Children with upper respiratory tract infections:A Multicenter Randomized Controlled Trial

引用

Chinese Journal of Integrative Medicine 2022年第5期28卷 387-393页

作者： LUO Hui SONG Gui-Hua MA Xiao-jian SUN Meng-meng ZHANG Man XIE Jian-rong PENG Shao Institute for Tibetan Medicine China Tibetology Research CenterBeijing(100101)China Department of Pediatrics the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou(450000)China Department of Pediatrics Huaihe Hospital of Henan UniversityZhengzhou(450000)China Department of Pediatrics the First Affiliated Hospital of Zhengzhou UniversityZhengzhou(475000)China School of Statistics Renmin University of ChinaBeijing(100872)China

Objective:To assess the effectiveness of Jiuwei Zhuhuang Powder(JWZH),a Tibetan patent medicine in treating upper respiratory tract infection(URTI)associated cough in children.Methods:The study was a multicenter,randomized,open-label,controlled trial.A total of 142 children aged 2 to 14 years old,with URTIassociated cough within 48 h of onset,were randomly assigned to two groups at a 1:1 ratio by computer-generated randomization sequence.Children were treated with JWZH(1 to 1.5 g,twice to thrice daily)in the treatment group or conventional treatment(Pediatric Paracetamol,Artificial Cow-bezoar and Chlorphenamine Maleate Granules,0.25 to 1 g,thrice daily)in the control group for 5 days.The primary endpoints were the time to cough resolution and 4-day cough resolution rate.The secondary endpoints were the daily improvement in symptom scores and cough resolution rate during the study period.Results:A total of 138 children were included in the intention-to-treat analysis,with 71 cases in the treatment group and 67 cases in the control group.Compared with the conventional treatment,the children receiving JWZH had a shorter time to cough resolution[hazard ratio,2.10;95%confidence interval(CI),1.29-3.40;P=0.003].The median time to cough resolution for children receiving JWZH was shorter than that of the conventional treatment(2 days vs.3 days;P0.05).Adverse events was reported in 5.6%(4/71)and 4.5%(3/67)in participants of JWZH and PPACCM groups(P>0.05),respectively,which were all mild and resolved without treatment.Conclusion:JWZH seemed to be a safe and effective therapy for URTI-associated cough in children.(Trial registration No.Chi CTR2000039421)

关键词： child cough upper respiratory tract infection Jiuwei Zhuhuang Powder randomized controlled trial Tibetan medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Meta-Analysis of the Effectiveness of Vitamin C in the Prevention and Treatment of Childhood upper respiratory tract infections

引用

Journal of Clinical and Nursing Research 2023年第1期7卷 30-37页

作者： Haitham Saeed Mohamed EA Abdelrahim Clinical Pharmacy Department Faculty of PharmacyBeni-Suef UniversityBeni-Suef 62514Egypt

Background:The effectiveness of vitamin C in the prevention and treatment of pediatric upper respiratory tract infections was evaluated in a meta-analysis.Methods:A total 2,573 children with upper respiratory tract infections were included in the meta-analysis,1,280 of whom received vitamin C and 1,293 who received control medication.The analysis of findings related to the studies included was done through random or fixed effects model to determine whether vitamin C supplementation could stop and control upper respiratory tract infections in children using mean difference(MD)with 95%confidence intervals(CIs).Results:On average,vitamin C-treated children had fewer upper respiratory tract infection bouts,their illness lasted shorter(MD-0.84;95%CI-1.47 to-0.20,P=0.009),and they were less contagious than the control.Conclusions:The number of episodes and illness duration of upper respiratory tract-infected pediatric subjects were considerably reduced in the intervention group(vitamin C)compared to the control.Due to the small sample size in four of 11 studies and the limited number of studies included for comparison,the outcomes should be carefully examined.

关键词： Vitamin C upper respiratory tract infection Number of episodes Duration of illness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Antibiotic prescribing patterns for upper respiratory tract infections in rural Western China

引用

Journal of Pharmaceutical Analysis 2010年第4期22卷 247-251页

作者： Li-Fang Dong1,2,Hong Yan2,Jun-Hong Gao3,Duo-Lao Wang4 1.Shaanxi Center for Disease Control and Prevention,Xi’an 710054,China 2.Teaching & Research Section of Epidemiology and Health Statistics,Department of Public Health,Medical School of Xi’an Jiaotong University,Xi’an 710061,China 3.Institute of Health Research,China North Industries Group Corporation,Xi’an 710065,China 4.Department of Epidemiology and Population Health,London School of Hygiene and Tropical Medicine,London,WC1E 7HT,UK. Shaanxi Center for Disease Control and Prevention Xi'an 710054 China Department of Public Health Medical School of Xi'An Jiaotong University Xi'an 710061 China Institute of Health Research China North Industries Group Corporation Xi'an 710065 China Department of Epidemiology and Population Health London School of Hygiene and Tropical Medicine London WC1E 7HT United Kingdom

Objective To explore the prescribing patterns of outpatients receiving antibiotics for upper respiratory tract infections(URTIs)in rural Western China and to identify the correlation in terms of doctors and patients characteristics.Methods Totally 7 678 prescriptions for URTIs were collected from 680 primary health village clinics of 40 counties across 10 provinces of Western China.Two outcome variables were used in the analysis:the occurrence of prescribing at least one antibiotic drug for an URTI and the occurrence of prescribing two or more antibiotics for an URTI.GEE logistic regression models were used to examine the socioeconomic and demographic determinants of the above two outcome variables.Results The percentage of prescribing at least one antibiotic for URTIs was 48.6% while the percentage of prescribing antibiotic combination(two or more antibiotics)was 4.6%.The two measurements of antibiotic utilization differed remarkably among the 10 provinces.Patients diagnosed with tonsillitis and faucitis had higher odds(OR=8.86 for tonsillitis and OR=4.64 for faucitis)of antibiotic prescription than patients with other diagnosis of URTIs.Patients with tonsillitis and faucitis also had higher odds(OR=3.82 for tonsillitis and OR=2.71 for faucitis)of multiple antibiotic prescription than those with other diagnosis of URTIs.The number of drugs per prescription and injection in prescriptions were also significant predictors of antibiotic and multiple antibiotic utilization for URTIs.Conclusion It is concluded that the percentage of antibiotic prescription for URTIs is higher in rural Western China than in most of other countries with available data and that prescriptions of antibiotics for URTIs are associated with residence regions of patients,URTI diagnosis and background information on drug prescription.

关键词： antibiotics pharmacoepidemiology upper respiratory tract infection rural population

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Observational Study of a Multi-Active Ingredient Over-the-Counter Cold Remedy Following Active Pharmacist Recommendation

引用

Open Journal of respiratory Diseases 2017年第1期7卷 41-52页

作者： Gillian Lisa Phillipson John David Hull Boleslaw Samoliński Procter&Gamble Greater London Innovation CentreSurreyUK Department of the Prevention of Environmental Hazards and Allergology Faculty of Health SciencesMedical University of WarsawWarsawPoland

Real-world user satisfaction with a fixed dose combination over-the-counter cold remedy (Vicks Symptomed Complete Cytrynowy hot drink;VSCC) was evaluated in a prospective, non-comparative, observational study involving 176 pharmacies in Poland from February to April 2015. 1391 participants completed a questionnaire in the pharmacy and several paper questionnaires at home following use of the product at their own discretion. Participants returned their completed questionnaires to the pharmacy. 1356 participants were included in the intent-to-treat analysis. Participants highly valued the advice from their pharmacist (97%, P < 0.0001, important vs. not important) and thought the quality of that advice was good (93%, P < 0.0001, good/very good vs. very bad-fair). 96% of participants found VSCC to be effective in some way against their cold symptoms (P < 0.0001, effective vs. not effective) and 68% of them stated that it was better than any other cold therapy they had used before (P < 0.0001, better/best vs. same/worse). Adverse event reporting was very low.

关键词： Common Cold upper respiratory tract infection Observational Pharmacy Over-the-Counter Fixed-Dose Combination Common Cold Symptoms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of PM2.5 On respiratory System and The Development of Probiotics in respiratory tract

Effects of PM2.5 On Respiratory System and The Development o...

引用

2017环境与公共健康学术会议暨中国环境科学学会环境医...

作者： ZHANG Yu XIAO Chunling Key Laboratory of Environmental Pollution and Health Shenyang Medical College

When the atmosphere is polluted,the amount of suspended particulate matter in the atmosphere will increase,especially PM(fine particles).They are smaller in size with a large surface area and high activity,it is a toxic and harmful substance that is suspended in the air for long time,it has a long distance transmission capacity,with a small atmospheric composition,but occupies an important position in air pollution.The Children’s respiratory tract is not a good resistant and the nasal mucosa is relatively weak resistance to pathogens less weak,pathogens from the nasal invasion to reach the throat,causing upper respiratory tract infection bronchial asthma,pneumonia and other symptoms.respiratory infection not only affects healthy development,but also causes a lot of complications,serious also life-threatening.The classification of respiratory tract bacteria,the preparation of probiotics by the dominant bacteria to regulate the diseases of the respiratory tract and the development of probiotics.It.It’s not a good resistant and the nasal mucosa is relatively weak resistance to pathogens less weak,pathogens from thenasal invasion to reach the throat,causing upper respiratory tract infection bronchial asthma,pneumonia and other symptoms.respiratory infection not only affects healthy development,but also causes a lot of complications,serious also life-threatening.In recent years,the treatment of intestinal probiotics and other diseases has reached a certain effect,but thhe application of probiotics in respiratory tract is less,the treatment of finished products needs further research and development.

关键词： PM2.5 respiratory tract upper respiratory tract infection respiratory probiotics

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：