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upconversion nanoparticles regulated drug&gas dual-effective nanoplatform for the targeting cooperated therapy of thrombus and anticoagulation

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Bioactive Materials 2022年第12期7卷 91-103页

作者： Shichen Liu Yao Sun Teng Zhang Longtao Cao Zhiwei Zhong Haoxin Cheng Qingqing Wang Zhuang Qiu Weimin Zhou Xiaolei Wang Department of Vascular Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang UniversityNanchangJiangxi330006PR China The National Engineering Research Center for Bioengineering Drugs and the Technologies Institute of Translational MedicineNanchang UniversityNanchangJiangxi330088PR China College of Chemistry Nanchang UniversityNanchangJiangxi330088PR China School of Public Health&Jiangxi Provincial Key Laboratory of Preventive Medicine NanchangJiangxi330088PR China

Thromboembolism is the leading cause of cardiovascular ***,for the lack of targeting,short half-life,low bioavailability and high bleeding risk of the classical thrombolytic drugs,pharmacological thrombolysis is usually a slow process based on *** addition,frequently monitoring and regulating coagulation functions are also required during(and after)the process of *** address these issues,a targeted thrombolytic and anticoagulation nanoplatform(UCATS-UK)is developed based on upconversion nanoparticles(UCNPs)that can convert 808 or 980 nm near-infrared(NIR)light into UV/blue *** nanoplatform can target and enrich in the thrombus *** thrombolysis and anticoagulation therapy thus could be realized through the controlled release of urokinase(UK)and nitric oxide(NO).Both in vitro and in vivo experiments have confirmed the excellent thrombolytic and anticoagulative capabilities of this multifunctional *** with the unique fluorescent imaging capability of UCNPs,this work is expected to contribute to the development of clinical thrombolysis therapy towards an integrated system of imaging,diagnosis and treatment.

关键词： Targeted drug delivery upconversion nanoparticles Controlled release Thrombus Anticoagulation

upconversion nanoparticles-Encoded Hydrogel Microbeads-Based Multiplexed Protein Detection

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Nano-Micro Letters 2018年第2期10卷 135-150页

作者： Swati Shikha Xiang Zheng Yong Zhang Department of Biomedical Engineering Faculty of Engineering National University of Singapore (NUS) NUS Graduate School for Integrative Sciences and Engineering Centre for Life Sciences (CeLS)

Fluorescently encoded microbeads are in demand for multiplexed applications in different *** to organic dye-based commercially available Luminex's x MAP technology, upconversion nanoparticles(UCNPs) are better alternatives due to their large antiStokes shift, photostability, nil background, and single wavelength excitation. Here, we developed a new multiplexed detection system using UCNPs for encoding poly(ethylene glycol) diacrylate(PEGDA) microbeads as well as for labeling reporter antibody. However, to prepare UCNPs-encoded microbeads, currently used swellingbased encapsulation leads to non-uniformity, which is undesirable for fluorescence-based multiplexing. Hence,we utilized droplet microfluidics to obtain encoded microbeads of uniform size, shape, and UCNPs distribution inside. Additionally, PEGDA microbeads lack functionality for probe antibodies conjugation on their *** to functionalize the surface of PEGDA microbeads(acrylic acid incorporation, polydopamine coating)reported thus far quench the fluorescence of UCNPs. Here,PEGDA microbeads surface was coated with silica followed by carboxyl modification without compromising the fluorescence intensity of UCNPs. In this study, droplet microfluidics-assisted UCNPs-encoded microbeads of uniform shape, size, and fluorescence were *** color codes were generated by mixing UCNPs emitting red and green colors at different ratios prior to encapsulation. UCNPs emitting blue color were used to label the reporter antibody. Probe antibodies were covalently immobilized on red UCNPs-encoded microbeads for specific capture of human serum albumin(HSA) as a model protein. The system was also demonstrated for multiplexed detection of both human C-reactive protein(hCRP) and HSA protein by immobilizing anti-h CRP antibodies on green UCNPs.

关键词： upconversion nanoparticles PEGDA microbeads Encoding Multiplexed bio-detection Single wavelength excitation

upconversion nanoparticles@AgBiS_(2) core-shell nanoparticles with cancer-cell-specific cytotoxicity for combined photothermal and photodynamic therapy of cancers

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Bioactive Materials 2022年第11期7卷 71-80页

作者： Zhaoyou Chu Tian Tian Zhenchao Tao Juan Yang Benjin Chen Hao Chen Wanni Wang Peiqun Yin Xiaoping Xia Hua Wang Haisheng Qian School of Biomedical Engineering School of Basic Medical SciencesAnhui Provincial Institute of Translational MedicineAnhui Medical UniversityHefeiAnhui230032PR China Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityAnhui Medical UniversityHefeiAnhui230032PR China Department of Radiation Oncology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui230031China Department of Obstetrics and Gynecology Children’s Hospital of Anhui Medical UniversityAnhui Provincial Children’s HospitalHefeiAnhui230051PR China

UCNPs@AgBiS_(2) core-shell nanoparticles that AgBiS_(2) coated on the surface of upconversion nanoparticles (UCNPs) was successfully prepared through an ion exchange reaction. The photothermal conversion efficiency of AgBiS_(2) can be improved from 14.7% to 45% due to the cross relaxation between Nd ions and AgBiS_(2). The doping concentration of Nd ions played a critical role in the production of reactive oxygen species (ROS) and enhanced the photothermal conversion efficiency. The NaYF4:Yb/Er/Nd@NaYF4:Nd nanoparticles endows strong upcon-version emissions when the doped concentration of Nd ions is 1% in the inner core, which excites the AgBiS_(2) shell to produce ROS for photodynamic therapy (PDT) of cancer cells. As a result, the as-prepared NaYF4:Yb/Er/ Nd@NaYF4:Nd@AgBiS_(2) core-shell nanoparticles showed combined photothermal/photodynamic therapy (PTT/ PDT) against malignant tumors. This work provides an alternative near-infrared light-active multimodal nano-structures for applications such as fighting against cancers.

关键词： upconversion nanoparticles Core-shell nanoparticles Photothermal conversion Facile synthesis Photodynamic therapy

upconversion nanoparticles for super-resolution quantification of single small extracellular vesicles

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eLight 2022年第1期2卷 262-273页

作者： Guan Huang Yongtao Liu Dejiang Wang Ying Zhu Shihui Wen Juanfang Ruan Dayong Jin Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW 2007Australia Smart Computational Imaging Laboratory(SCILab) School of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjingJiangsu 210094China School of Biomedical Engineering Faculty of Engineering and Information TechnologyUniversity of Technology SydneySydneyNSW 2007Australia School of Clinical Medicine Faculty of Medicine&HealthUNSW SydneySydneyNSW 2052Australia Electron Microscope Unit UNSW SydneySydneyNSW 2052Australia ARC Research Hub for Integrated Device for End‑User Analysis at Low Levels Faculty of ScienceUniversity of Technology SydneySydneyNSW 2007Australia UTS‑SUStech Joint Research Centre for Biomedical Materials and Devices Department of Biomedical EngineeringSouthern University of Science and TechnologyShenzhenGuangdong 518055China

Although small EVs(sEVs)have been used widely as biomarkers in disease diagnosis,their heterogeneity at single EV level has rarely been *** is because high-resolution characterization of sEV presents a major challenge,as their sizes are below the optical diffraction ***,we report that upconversion nanoparticles(UCNPs)can be used for super-resolution profiling the molecular heterogeneity of *** show that Er3+-doped UCNPs has better brightness and Tm3+-doped UCNPs resulting in better resolution beyond diffraction *** an orthogonal experimental design,the specific targeting of UCNPs to the tumour epitope on single EV has been cross validated,resulting in the Pearson’s R-value of 0.83 for large EVs and~65%co-localization double-positive spots for ***,super-resolution nanoscopy can distinguish adjacent UCNPs on single sEV with a resolution of as high as 41.9 *** decreasing the size of UCNPs from 40 to 27 nm and 18 nm,we observed that the maximum UCNPs number on single sEV increased from 3 to 9 and 21,*** work suggests the great potentials of UCNPs approach“digitally”quantify the surface antigens on single EVs,therefore providing a solution to monitor the EV heterogeneity changes along with the tumour progression progress.

关键词： Extracellular vesicles upconversion nanoparticles Super-resolution Liquid biopsy

TiO_2 composite nanotubes embedded with CdS and upconversion nanoparticles for near infrared light driven photocatalysis

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Chinese Journal of Catalysis 2017年第11期38卷 1851-1859页

作者： Wanni Wang Fu Zhang Chuanling Zhang Yang Wang Wei Tao Sheng Cheng Haisheng Qian School of Biological and Medical Engineering Hefei University of Technology Hefei 230009 Anhui China School of Chemistry and Chemical Engineering Hefei University of Technology Hefei 230009 Anhui China Instrumental Analysis Center Hefei University of Technology Hefei 230009 China

We report a colloidal process to coat a layer of TiO2onto SiO2composite nanofibers containing embedded CdS and upconversion nanoparticles(UCNPs).The SiO2composite nanofibers were fabricated by *** improve the energy transfer efficiency,UCNPs and CdS nanoparticles were bound in close proximity to each other within the SiO2matrix.β‐NaYF4:Yb(30%),Tm(0.5%)@NaYF4:Yb(20%),Er(2%)core–shell nanoparticles were used as nanotransducers for near infrared *** nanoparticles exhibited enhanced upconversion fluorescence compared withβ‐NaYF4:Yb(30%),Tm(0.5%)orβ–NaYF4:Yb(30%),Tm(0.5%)@*** morphologies,size and chemical compositions have been extensively investigated using field emission scanning electron microscopy(FESEM),transmission electron microscopy(TEM),X‐ray diffraction(XRD)and X‐ray photoelectron spectra(XPS),*** TEM images showed that the TiO2composite nanotubes were embedded with a large amount of UCNPs and CdS *** composite TiO2nanotubes degraded more than90%of rhodamine B(RhB)dye during20min of irradiation by simulated solar *** particular,more than50%of RhB was decomposed in70min,under irradiation of near infrared light(NIR).This high degradation was attributed to the full spectrum absorption of solar light,and the enhanced transfer efficiency for near infrared *** as‐prepared nanostructures can harness solar energy,and provide an alternative to overcome energy shortages and environmental protection.

关键词： TiO2 nanotubes upconversion nanoparticles Energy transfer Photocatalysis Nanotransducer

Pulsed laser reshaping and fragmentation of upconversion nanoparticles-from hexagonal prisms to ID nanorods through“Medusa”-like structures

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Nano Research 2021年第4期14卷 1141-1148页

作者： Laszlo Sajti Denis N.Karimov Vasilina V.Rocheva Nataliya A.Arkharova Kirill V.Khaydukov Oleg I.Lebedev Alexey E.Voloshin Alla N.Generalova Boris N.Chichkov Evgeny V.Khaydukov AIT Austrian Institute of Technology GmbH Wiener Neustadt2700Austria Federal Scientific Research Centre“Crystallography and Photonics”Russian Academy of Sciences Moscow119333Russia Laboratoire CRISMAT UMR6508CNRS-ENSIACENUniversite CaenCaen14050France Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences Moscow 117997Russia Institutfiir Quantenoptik Leibniz Universitat HannoverHannover30167Germany Center of Biomedical Engineering Institute of Molecular Medicine Sechenov First Moscow State Medical UniversityMoscow119991Russia

One dimensional(1D)nanostructures attract considerable attention,enabling a broad application owing to their unique ***,the precise mechanism of 1D morphology attainment remains a matter of *** this study,ultrafast picosecond(ps)laser-induced treatment on upconversion nanoparticles(UCNPs)is offered as a tool for 1 D-nanostructures ***,reshaping through recrystallization process and bioadaptation of initially hydrophobic(β-Na_(1.5)Y_(1.5_)F_(6):Yb^(3+),Tm^(3+)/β-Na_(1.5)Y_(1.5_)F_(6))core/shell nanoparticles by means of one-step laser treatment in water are demonstrated.“True”1D nanostructures through"Medusa^-like structures can be obtained,maintaining anti-Stokes luminescence functionalities.A matter of the one-dimensional UCNPs based on direction of energy migration processes is *** proposed laser treatment approach is suitable for fast UCNP surface modification and nano-to-nano transformation,that open unique opportunities to expand UCNP applications in industry and biomedicine.

关键词： upconversion nanoparticles fluoride crystals upconversion nanorods one-dimensional(1D)structures laser-induced reshaping

Modulator-directed assembly of hybrid composites based on metalorganic frameworks and upconversion nanoparticles

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Nano Research 2023年第1期16卷 1482-1490页

作者： Yanhui Feng Xingjun Li Shan Lu Renfu Li Zhongliang Gong Xiaoying Shang Yifan Pei Wei Zheng Datao Tu Xueyuan Chen CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Key Laboratory of Nanomaterialsand State Key Laboratory of Structural ChemistryFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of chemistry Fuzhou universityFuzhou 350108China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China

Hybrid composites made of metal-organic frameworks(MOFs)and lanthanide-doped upconversion nanoparticles(UCNPs)have attracted considerable interest for their synergistically enhanced functions in various applications such as chemical sensing,photocatalysis,anticounterfeiting and ***,precise assembly of MOF/UCNP hybrid composites with tunable morphologies remains a challenge due to the lack of effective synthetic methods and fundamental understanding of the growth ***,we propose a modulator-directed assembly strategy to synthesize a series of ZIF-8@UCNP composites(ZIF-8=zeolitic imidazolate framework-8).The UCNPs densely paved on the surface of ZIF-8 microcrystals and endowed the composites with intense upconversion blue emission,which were verified by steady-state/transient photoluminescence(PL)spectroscopy and single-particle ***(EDA)was firstly used as a modulator to fine-tune the predominant MOF facets and realized distinct morphologies of the *** adjusting the concentration of EDA from 0 to 25 mmol/L,the morphology of the ZIF-8@UCNP composites was tuned from rhombic dodecahedron(RD)to truncated rhombic dodecahedron(TRD),cube with truncated edges(CTE),cube,and finally a unique form of interpenetration twins(IT).The nucleation and growth process of the ZIF-8@UCNP composites was monitored by time-dependent scanning electron microscopy(SEM)images and the formation mechanism was thoroughly ***,we demonstrated that the strategy for assembly of morphology-controllable ZIF-8@UCNP composites was generally applicable to various UCNPs with different sizes and *** proposed strategy is expected to open up new avenues for the controllable synthesis of MOF/UCNP composites toward diverse applications.

关键词： metal-organic frameworks upconversion nanoparticles hybrid composites ethylenediamine modulator

Molecularly imprinted polymer based on upconversion nanoparticles for highly selective and sensitive determination of Ochratoxin A

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Journal of Central South University 2019年第3期26卷 515-523页

作者： YAN Zhen FANG Guo-zhen State Key Laboratory of Food Nutrition and Safety Tianjin University of Science and Technology

A novel molecularly imprinted polymer (MIP) based on upconversion nanoparticles (UCNPs) was successfully synthesized for determination of Ochratoxin A (OTA). The MIP was developed on the silica-coated UCNPs using N-(1-hydroxy-2-naphthoyl amido)-(L)-phenylalanine (HNA-Phe) as the alternative template. The final composite combined the advantages of the high selectivity of MIP with the high fluorescence intensity of UCNPs which was selective and sensitive to OTA. Under the optimal condition, the fluorescence intensity of UCNPs@SiO2@MIP decreases linearly when the concentration of OTA increases from 0.05 to 1.0 mg/L. The detection limit of OTA with the method was 0.031 mg/L. At three spiked concentration levels (50, 100 and 200 μg/kg), the recovery ranges of OTA in corn, rice and feed are 88.0%–91.6%, 80.2%–91.6% and 89.2%–90.4%, respectively.

关键词： molecularly imprinted polymer upconversion nanoparticles fluorescent sensing Ochratoxin A

A DNA sensor based on upconversion nanoparticles and two-dimensional dichalcogenide materials

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Frontiers of Chemical Science and Engineering 2021年第4期15卷 935-943页

作者： Konstantina Alexaki Davide Giust Maria-Eleni Kyriazi Afaf H.El-Sagheer Tom Brown Otto L.Muskens Antonios G.Kanaras School of Physics and Astronomy Faculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK Department of Chemistry University of OxfordChemistry Research LaboratoryOxford OX13TAUK Chemistry Branch Department of Science and MathematicsFaculty of Petroleum and Mining EngineeringSuez UniversitySuez 43721Egypt Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK

We demonstrate the fabrication of a new DNA sensor that is based on the optical interactions occurring between oligonucleotide-coated NaYF4:Yb^(3+);Er^(3+) upconversion nanoparticles and the two-dimensional dichalcogenide materials,MoS_(2) and WS_(2).Monodisperse upconversion nanoparticles were functionalized with single-stranded DNA endowing the nanoparticles with the ability to interact with the surface of the two-dimensional materials via van der Waals interactions leading to subsequent quenching of the upconversion *** contrast,in the presence of a complementary oligonucleotide target and the formation of double-stranded DNA,the upconversion nanoparticles could not interact with MoS_(2) and WS_(2),thus retaining their inherent fluorescence *** this sensor we were able to detect target oligonucleotides with high sensitivity and specificity whilst reaching a concentration detection limit as low as 5 mol·L^(-1),within minutes.

关键词： upconversion nanoparticles DA sensor two-dimensional materials MoS_(2) WS_(2)