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Diagnosis of voiding dysfunction by pressure-flow study in women

World Journal of Clinical Urology 2016年第1期5卷 29-36页

作者： Juan Pablo Valdevenito Annerleim Walton-Diaz Urodynamics Unit Department of Urology Hospital Clinico Universidad de Chile

Pressure-flow study(PFS) of micturition is the best method to quantitatively analyse voiding function. It allows us to distinguish voiding lower urinary tract symptoms and low urine flow rate caused by bladder outlet obstruction(BOO) from those caused by detrusor underactivity(DU). Voiding dynamics are significantly different in men and women and the established criteria for urodynamic diagnosis in men do not apply to women. Basic principles of voiding mechanics and voiding patterns in asymptomatic women are analyzed. Although attempts have been made to establish a consensus for diagnosis of BOO in women with pressure-flow cutoff, video-urodynamics criteria and nomograms, currently there is no consensus. There is no standard urodynamic test to diagnose and quantify DU in women for which further investigations are needed. Modified projected isovolumetric pressure(to assess detrusor contraction strength) and pressure-flow cutoff criteria have been used. The diagnosis of voiding dysfunction in women is challenging, requiring PFS with very good quality control and often involves integrating clinical and radiographic data to make the final assessment.

关键词： Bladder outlet obstruction Pressure-flow studies Urodynamics Women Detrusor underactivity

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Does an “Overactive to Underactive Bladder Transition” Phenomenon Exist in a Rat Lumbar Spinal Canal Stenosis Model?

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Open Journal of Urology 2015年第5期5卷 57-64页

作者： Noritoshi Sekido Jun Kida Daisuke Wakamatsu Hiroki Okada Hidekazu Matsuya Department of Urology School of Medicine Faculty of Medicine Toho University Medical Center Ohashi Hospital Tokyo Japan Group2 Discovery Research Laboratories Ono Pharmaceutical Co. Ltd. Osaka Japan

Purpose: To investigate the association between the maximum cystometric capacity (MCC) and other cystometric parameters in lumbar canal stenosis (LCS) rats. Material and Methods: One small hole was drilled at the fifth lumbar vertebral arch (Sham), and a rectangular piece of silicone rubber was then placed in the epidural space (LCS) of Wister rats. Two weeks after surgery, awake cystometry was performed. LCS rats were divided into three groups: Group A (n = 5, MCC 1.81 mL). Cystometric parameters were investigated in sham and LCS groups. Results: MCC did not significantly correlate to the frequency of non-voiding contractions (NVCs), voided volume (VV), or maximum intravesical pressure during voiding (Pmax), but significantly positively correlated to postvoid residual urine volume (PVR) and residual urine rate (RUR) (Spearman’s correlation coefficients (ρ) = 0.8973 (p underactivity regardless of MCC. NVCs did not significantly increase in LCS rats with decreased MCC, but the trend toward higher NVCs with smaller MCC was significant.

关键词： Underactive Bladder Detrusor underactivity Lumbar Canal Stenosis Animal Model Overactive Bladder

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