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umbilical cord blood serum therapy for the management of persistent corneal epithelial defects

International Journal of Ophthalmology(English edition) 2014年第5期7卷 807-810页

作者： Elif Erdem Meltem Yagmur Inan Harbiyeli Hande Taylan-Sekeroglu Reha Ersoz Department of Ophthalmology Faculty of MedicineCukurova University Ermenek State Hospital Department of Ophthalmology Faculty of MedicineHacettepe University

AIM:Toevaluatetheroleofumbilical cord blood serum(CBS) therapy in cases with persistent corneal epithelial defects(PED).METHODS:Sixteen eyes of 14 patients with PED who were resistant to conventional treatment were treated with 20% umbilical cord serum eye drops. Patients were followed-up weekly until epithelization was *** collected data included the grade of corneal lesion(Grade I: epithelial defect +superficial vascularization,Grade II: epithelial defect +stromal edema, Grade III:corneal ulcer +stromal melting), the size of epithelial defect(pretreatment, 7th, 14 thand 21stdays of treatment),and follow-up time was evaluated ***:The mean size of epithelial defect on two perpendicular axes was 5.2×4.6-mm2(range: 2.5-8 mm×2.2-9 mm2). Mean duration of treatment was 8.3 ±*** therapy was effective in 12 eyes(75%) and ineffective in 4 eyes(25%). The epithelial defects in 4ineffective eyes were healed with amniotic membrane transplantation and tarsorrhaphy. The rate of complete healing was 12.5% by 7d, 25% by 14 d, and 75% by 21 *** healing time was prolonged in Grade III eyes in comparison to eyes in Grade I or Grade ***:The results of the current study indicated the safety effectiveness of CBS drops in the management of PED. The grade of disease seems have a role on the healing time.

关键词： persistent corneal epithelial defect umbilical cord serum eye drop neurotrophic keratitis

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