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Ultrafine Fibrous Three Dimensional Scaffolds for Controlled Drug Delivery

Ultrafine Fibrous Three Dimensional Scaffolds for Controlled...

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作者： S.M.Kamrul Hasan 东华大学

学位级别：硕士

Inflammation is a common phenomenon in wound healing and upon implantation of cell supportive matrices(i.e. scaffolds) on defect sites. Local and nonlocal drug administrations are the two ways of delivering drugs(for example anti-inflammatory drugs) to wound sites. Since localized drug delivery via scaffolds can overcome the disadvantages of systemic(nonlocal) drug delivery, the use of scaffolds as drug delivery vehicle is growing rapidly in tissue engineering field. Moreover, in most cases of tissue regeneration, it is necessary to develop scaffolds that can mimic native three dimensional(3D) extracellular matrices(ECMs) either in vitro or in vivo. In such cases, the scaffolds should bear the properties required for high cell infiltration. For exact mimicking the native 3D ECMs, ultrafine fibrous morphology of the scaffold with sufficient inter fiber gaps(for high cell infiltration) is obvious. Recently, ultrafine fibrous three dimensional(UF3D) scaffolds were developed via ultra-low concentration phase separation technique(ULCPS) where the scaffolds exhibited the potential to mimic native 3D ECMs like morphology. If drugs can be delivered from UF3 D scaffolds in a sustained manner, it can add more value to the tissue engineering field. But no work reported drug loading and release profile from UF3 D scaffolds and only a limited number of materials were used to prepare such scaffolds before. Proteins were used frequently by researchers in tissue engineering field for their biodegradability and biocompatibility. Moreover, water is used as solvent for most proteins which reduces risk of toxic contamination. So, proteins namely gelatin(Gt), regenerated silk fibroin(RSF) and fibrinogen(FB) were initially chosen in this work for fabrication of UF3 D scaffolds and followed by drug loading and release experiments. The influences of the polymer solution concentration and the amount of the crosslinker, citric acid(CA), on the morphologies of scaffolds were investigated by o

关键词： Ultrafine fibrous scaffold drug delivery crosslinking ultralow concentration phase separation pore size

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