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Pharmacokinetic and Relative Bioavailability of Three Secoiridoid Glycosides in Beagle Dog Plasma After Oral Administration of Conventional and Enteric-Coated Capsules of Gentianella acuta Extract

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World Journal of Traditional Chinese Medicine 2021年第2期7卷 246-253页

作者： Zhi-Bin Wang Kai Li Meng Wang Gao-Song Wu Yu-Jin Bi Hai-Xue Kuang College of Pharmacy Key Laboratory of Chinese Materia Medica(Ministry of Education)Heilongjiang University of Chinese MedicineHarbin 150040China SunGen Pharma LLC303C Collage Road EastPrincetonNJ08540USA

Objective:To simultaneously investigate the pharmacokinetics of gentiopicroside,sweroside,and swertiamarin,which are constituents of Gentianella acuta,by developing and validating a simple,sensitive,and fast ultra-high-performance liquid chromatography–tandem mass spectrometry *** and Methods:Blood samples were collected from the forward limb veins of six beagle dogs following oral gavage with ***,the whole plant extract(39.90 mg/kg).Plasma samples were processed using liquid–liquid *** analytes and paeoniflorin(internal standard[IS])were separated using an Acquity?UPLC ethylene bridged hybrid amide column(2.1 mm×100 mm,1.7μm)with isocratic elution using a mobile phase consisting of acetonitrile and 0.1%formic acid in water(80:20,v/v)at a flow rate of 0.4 mL/*** was performed using multiple reaction monitoring of the fragmentation transitions at m/z 401.1→179.0,403.1→195.0,419.1→179.0,and 525.2→449.1 for gentiopicroside,sweroside,swertiamarin,and the IS,***:The linearity of the analytical response was good and the calibration curves were linear over concentration ranges of 1.20–192.0,0.40–159.0,and 0.20–209.3 ng/mL for gentiopicroside,sweroside,and swertiamarin,*** extraction recovery was in the range of 84.72%–91.34%,84.58%–93.43%,and 82.75%–91.37%for gentiopicroside,sweroside,and swertiamarin,***:The method was successfully used to evaluate the pharmacokinetic parameters of gentiopicroside,sweroside,and swertiamarin in beagle dogs.

关键词： Beagle dog Gentianella acuta pharmacokinetics secoiridoid glycosides ultra-high-performance liquid chromatography-tandem mass spectrometry

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