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Macrophage involvement in the pathological evolution of ulcerative colitis-associated colon cancer and progress of related traditional Chinese medicine drug interventions

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Traditional Medicine Research 2023年第8期8卷 37-52页

作者： Jun-Yu Ke Jin-Bin Song Long Li Zhen-Fan He Zhuo-Jian Huang Zheng-Lin Liu Gui-Rong Chen Su-Ru Wen Heng-Li Zhou Hui-Lin Ma Qun Du Yong-Qiang Wu Yan-Wu Li Xin-Lin Chen School of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China Department of Surgery Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineGaozhou 525200China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405China The First Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405China

Intestinal macrophages are essential players in intestinal inflammation and intestinal immune *** macrophages have the ability to polarize into two distinct phenotypes based on various environmental *** phenotypes include the typically activated pro-inflammatory M1 phenotype and the alternatively activated anti-inflammatory M2 *** normal circumstances,intestinal macrophages prevent inflammatory damage to the ***,when genetic and environmental factors influence the polarization of intestinal macrophages,it can lead to an imbalance in M1/M2 macrophage activation and subsequently an imbalance in the control of intestinal *** transforms physiological inflammation into pathological intestinal *** patients with ulcerative colitis-associated cancer(UC-CRC),intestinal inflammatory disorders are closely associated with intestinal M1/M2 macrophage polarization ***,restoring the polarization equilibrium of M1/M2 macrophages might be an evidence of traditional Chinese medicine in the treatment of UC-CRC,the pivotal role o effective measure to prevent and treat *** paper aims to examine the clinicalf macrophage polarization in UC-CRC pathogenesis,and the potential mechanisms of traditional Chinese medicine in regulating macrophage polarization to treat *** goal is to provide novel insights into the clinical practice,basic research,and drug development of UC-CRC.

关键词： ulcerative colitis ulcerative colitis-associated cancer macrophage polarization herbal compound herbal monomer signaling pathway

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