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Personalized targeted therapy for esophageal squamous cell carcinoma

World Journal of Gastroenterology 2015年第25期21卷 7648-7658页

作者： Xiaozheng Kang Keneng Chen Yicheng Li Jianying Li Thomas A D'Amico Xiaoxin Chen Key Laboratory of Carci-nogenesis and Translational Research (Ministry of Education) The First Department of Thoracic Surgery Peking University Cancer Hospital and Institute Cancer Research Program Julius L. Chambers Biomedical Biotechnology Research Institute North Carolina Central University Euclados Bioinformatics Solutions Division of Thoracic Surgery Duke University Medical Center Center for Esophageal Disease and Swallowing Division of Gastroenterology and Hepatology Department of Medicine University of North Carolina at Chapel Hill

Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial.

关键词： Cancer heterogeneity Cultured tumorcells Driver mutation Drug side effects Esophagealsquamous cell carcinoma Exceptional responder Highthroughputnucleotide sequencing Neoplasm drugresistance Personalized medicine Xenograft model

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Monitoring disease progression and treatment efficacy with circulating tumor cells in esophageal squamous cell carcinoma: A case report

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World Journal of Gastroenterology 2015年第25期21卷 7921-7928页

作者： Yuan-Yuan Qiao Kai-Xuan Lin Ze Zhang Da-Jin Zhang Cheng-He Shi Ming Xiong Xiu-Hua Qu Xiao-Hang Zhao Center for Basic Medical Sciences Navy General Hospital of Chinese PLA Graduate School of Southern Medical University State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

This study investigated whether changes in circulating tumor cell(CTC) numbers reflect tumor progression and treatment efficacy in esophageal squamous cell carcinoma(ESCC). A 47-year-old male patient with ESCC is presented in this case study. The patient was evaluated for a series of serum tumor markers and subjected to radiological examinations before and after surgery and during follow-up over the course of five years. In addition, the CTCs in 7.5 m L of peripheral blood were enriched by magneticactivated cell sorting negative selection and identified by immunofluorescence staining. Serum tumor markers remained within normal ranges and were discordant with imaging scans during the follow-up. Initially, one CTC was detected in the peripheral blood sample, and 14 were observed seven days after the operation. After 12 wk, subcutaneous metastases and bone metastases occurred, and the number of CTCs increased to 84. After 48 wk, lung metastases were noted, and the CTC level was 21. At 104 wk, the number of CTCs was 14, and disease recurrence was detected by positron emission tomography-computed tomography. The CTC counts were in accord with the imaging studies at several time points. The additional information provided by CTC enumeration could thus facilitate monitoring of disease status and treatment efficacy and provide support for treatment decisions.

关键词： Individualized treatment Adjuvant therapy Esophageal squamous cell carcinoma Circulating tumorcells

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