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Ultrastable Near-Infrared Aggregation-Induced Emission Nanoparticles as a Fluorescent Probe:Long-Term tumor monitoring and Lipid Droplet Tracking

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CCS Chemistry 2021年第6期3卷 1596-1606页

作者： Haijun Ma Danning Hu Jiajia Zhao Mei Tian Jinying Yuan Yen Wei MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084 Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of ChemistryChinese Academy of SciencesBeijing 100190 Department of Nuclear Medicine and Medical PET Center The Second Hospital of Zhejiang University School of MedicineHangzhou 310009 Department of Chemistry Center for NanotechnologyInstitute of Biomedical TechnologyChung Yuan Christian UniversityTaoyuan 32023

Effective real-time tumor monitoring and cell tracking are of great importance for precise diagnosis and therapy of tumors,and also for the surveillance of biological *** this study,a new organic fluorescent nanoprobe(named TPATBT NPs)with unique aggregation-induced emission(AIE)characteristics has been obtained for the first time via facile synthesis to achieve real-time and long-term monitoring in living *** advantages of TPATBT NPs include small size(∼80 nm),a large Stokes shift(∼150 nm),high stability,good dispersibility in aqueous media,and *** addition,such NPs have showed excellent bioimaging performance and unusual long-term tumor monitoring *** red fluorescence signals inside MDA-MB-231 cells last for longer than 10 generations(18 days).Moreover,the cellular uptake of TPATBT NPs has been found to highly rely on energy-dependent endocytosis and clathrin-mediated endocytosis,and to primarily accumulate in lipid droplets(LDs),which can lead to targeted LD cellular imaging and ***,TPATBT NPs can work as an excellent fluorescent nanoprobe for long-term monitoring of malignant tumor growth and dynamic biological processes.

关键词： long term lipid droplets tracking tumor monitoring near infrared aggregation-induced emission

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