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Self-monitored Nd-doped MoSe_(2) nanosheets with near-infrared luminescent sensing for photothermal therapy

Journal of Materiomics 2024年第1期10卷 163-172页

作者： Congcong Wang Yu Meng Zewen Su Junqiang Dong Yanbang Lian Youqiang Huang Yinyan Li Shiqing Xu Gongxun Bai Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province College of Optical and Electronic TechnologyChina Jiliang UniversityHangzhou310018China Oncology Department The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou450052China Radiology Department The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou450052China

The acquisition of real-time temperature monitoring during photothermal therapy is significant to prevent unnecessary damage to healthy ***,owing to complexity and diverse factors in microenvironment of cells,there still remain considerable challenges in achieving noninvasive temperature measurement and manipulation in therapeutic ***,biocompatible Nd-doped MoSe_(2) nanosheets have been developed on the premise of excellent photothermal effect,which manifest desirable photoluminescence and distinct temperature self-monitored capability in near-infrared Ⅰ and Ⅱ *** on thermally coupled energy levels of Nd ions,the real-time monitoring on temperature changes in intracellular environment can be realized which provide instant temperature feedbacks to avoid side effects from *** of detrimental elements such as F and Pb,the objective nanosheets manifest satisfactory biosafety and can induce effective tumor ablation under near-infrared irradiation with photothermal conversion efficiency up to 40.8%,providing an innovative vision for developing more precisely and safely photothermal approaches.

关键词： Photothermal conversion tumor ablation Temperature feedback Transition metal dichalcogenide Optical thermometer

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Photothermal scaffolds/surfaces for regulation of cell behaviors

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Bioactive Materials 2022年第2期7卷 449-477页

作者： Yangcui Qu Kunyan Lu Yanjun Zheng Chaobo Huang Guannan Wang Yanxia Zhang Qian Yu College of Biomedical Engineering&the Key Laboratory for Medical Functional Nanomaterials Jining Medical UniversityJining272067PR China Joint Laboratory of Advanced Biomedical Materials(NFU-UGent) College of Chemical EngineeringNanjing Forestry UniversityNanjing210037PR China Department of Cardiovascular Surgery of the First Affiliated Hospital&Institute for Cardiovascular Science Soochow UniversitySuzhou215006PR China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123PR China

Regulation of cell behaviors and even cell fates is of great significance in diverse biomedical applications such as cancer treatment,cell-based therapy,and tissue *** the past decades,diverse methods have been developed to regulate cell behaviors such as applying external stimuli,delivering exogenous molecules into cell interior and changing the physicochemical properties of the substrates where cells *** scaffolds/surfaces refer to a kind of materials embedded or coated with photothermal agents that can absorb light with proper wavelength(usually in near infrared region)and convert light energy to heat;the generated heat shows great potential for regulation of cell behaviors in different *** the current review,we summarize the recent research progress,especially over the past decade,of using photothermal scaffolds/surfaces to regulate cell behaviors,which could be further categorized into three types:(i)killing the tumor cells via hyperthermia or thermal ablation,(ii)engineering cells by intracellular delivery of exogenous molecules via photothermal poration of cell membranes,and(iii)releasing a single cell or an intact cell sheet via modulation of surface physicochemical properties in response to *** the end,challenges and perspectives in these areas are commented.

关键词： Photothermal scaffolds Photothermal surfaces tumor ablation Intracellular delivery Cell detachment

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Safety trial of high-intensity focused ultrasound therapy for pancreatic cancer

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World Journal of Gastroenterology 2014年第28期20卷 9570-9577页

作者： Atsushi Sofuni Fuminori Moriyasu Takatomo Sano Fumihide Itokawa Takayoshi Tsuchiya Toshio Kurihara Kentaro Ishii Syujiro Tsuji Nobuhito Ikeuchi Reina Tanaka Junko Umeda Ryosuke Tonozuka Mitsuyoshi Honjo Shuntaro Mukai Mitsuru Fujita Takao Itoi Department of Gastroenterology and Hepatology Tokyo Medical University

AIM:To evaluate the safety and clinical application of high-intensity focused ultrasound(HIFU)therapy for unresectable pancreatic cancer(PC).METHODS:Thirty PC patients(16 cases in stage III and 14 cases in stage IV)with visualized pancreatic tumors were admitted for HIFU therapy as an optional local therapy in addition to systemic chemotherapy or *** consent was *** study began at the end of 2008 and was approved by the ethics committee of our hospital[Institutional Review Board(IRB):890].The HIFU device used was the FEP-BY02(Yuande Bio-Medical Engineering,Beijing,China).RESULTS:The mean tumor size after HIFU therapy changed to 30.9±1.7 mm from 31.7±1.7 mm at *** were no significant changes in tumor size,mean number of treatment sessions(2.7±0.1 mm),or mean total treatment time(2.4±0.1 h).The rate of symptom relief effect was 66.7%.The effectiveness of primary lesion treatment was as follows:complete response,0;partial response,4;stable disease,22;progressive disease,*** after HIFU therapy included 2 operations,24 chemotherapy treatments,and 4 best supportive care *** events occurred in 10%of cases,namely pseudocyst formation in 2 cases and mild pancreatitis development in ***,no severe adverse events occurred in this ***:We suggest that HIFU therapy is safe and has the potential to be a new method of combination therapy for PC.

关键词： High-intensity focused ultrasound Pancreatic cancer Safety trial tumor ablation Ultrasonography

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Photoconversion-Tunable Bodipy Vesicles forWavelength-Dependent Photo-Induced Cancer Therapy

Photoconversion-Tunable Bodipy Vesicles forWavelength-Depend...

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中国化学会第四届卟啉与酞菁学术研讨会

作者： Hui He Shuangshuang Ji Zhengqing Guo Youliang Zhao Huabing Chen Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases College of Pharmaceutical SciencesSoochow University School of Radiological and Interdisciplinary Sciences(RAD-X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutionsand School of Radiation Medicine and ProtectionSoochow University Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationState and Local Joint Engineering Laboratory for Novel Functional Polymeric MaterialsCollege of ChemistryChemical Engineering and Materials ScienceSoochow University

Photo-induced cancer therapy,such as photodynamic therapy（PDT） or photothermal therapy（PTT） treatment has shown great promise in precision nanomedicine owing to their selectivity,low systemic toxicity,negligible drug resistance,and non-invasive modality.1-3 In this presentation,we will demonstrate wavelength-dependent photoconversion regulation of Bodipy fluorophores through polymeric vesicles for either PDT or PTT treatment（Scheme 1）.Bodipy is assembled with the terpolymer into polymeric vesicles in the conformation of both J-type and H-type aggregates,causing the red-shifted absorption into the near-infrared（NIR） region,low radiative transition,and ideal resistance to *** 660 nm irradiation,the vesicles mainly display remarkable singlet oxygen quantum yield through singlet-to-triplet transition,thereby leading to abundant intracellular singlet oxygen at the tumor for effective ***,under 785 nm irradiation,they primarily possess distinct photothermal conversion efficiency through non-radiative transition together with mild singlet oxygen generation,thus leading to potent hyperthermia at the tumor for robust PDT-synergized ***,the vesicles have preferable cellular uptake,effective cytoplasmic drug translocation through singlet oxygen-mediated lysosomal disruption,and enhanced tumor accumulation,which contribute to the total tumor ablation without any regrowth.4

关键词： Bodipy photodynamic therapy photothermal therapy polymeric vesicles tumor ablation

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An Overview of CyberKnife Radiosurgery

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Chinese Journal of Clinical Oncology 2006年第4期3卷 229-243页

作者： John R.Adler Department of Neurosurgery Stanford University Medical School Stanford Jr.

Stereotactic radiosurgery is a non-invasive procedure that utilizes precisely targeted radiation as an ablative surgical tool. Conventional radiosurgery devices, such as the Gamma Knife, rely upon skeletally attached Stereotactic frames to immobilize the patient and precisely determine the 3D spatial position of a tumor. A relatively new instrument, the CyberKnife (Accuray, Inc., Sunnyvale, CA), makes it possible to administer radiosurgery without a frame. The CyberKnife localizes clinical targets using a very accurate image-to-image correlation algorithm, and precisely cross-fires high-energy radiation from a lightweight linear accelerator by means of a highly manipulable robotic arm. CyberKnife radiosurgery is an effective alternative to conventional surgery or radiation therapy for a range of tumors and some non-neoplastic disorders. This report will describe CyberKnife technology and oncologic applications in neurosurgery and throughout the body.

关键词： radiosurgery CyberKnife imaged.-guided tumor ablation stereotactic.

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