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Journal of Biosciences and Medicines 2020年第4期8卷 26-44页

作者： Dinesh Aryal Keith E. Jackson School of Basic Pharmaceutical and Toxicological Sciences College of Pharmacy University of Louisiana at Monroe Monroe LA USA

Disturbances in acid-base balance leading to the development of hypertension are currently gaining increased attention among researchers. Perturb acid-base balance characterized by metabolic acidosis has been demonstrated in hypertensive animals and humans. Research suggests that acid-base changes are not only the consequences of elevated blood pressure but can precede the development of hypertension. However, no exact mechanism has been identified to link acid-base imbalance with alterations in blood pressure. The kidney proximal tubule is the major site for maintaining normal bicarbonate concentrations which is an important component of acid-base balance. Acid-base transporter proteins in the renal proximal tubule such as Na+/HCO-3?cotransporters, Na+/H+ exchangers, and anion-exchangers play important roles in controlling acid secretion, ammonia production and bicarbonate reabsorption for maintaining acid-base balance. It is well known that sodium retention in the renal tubules leads to increase in blood volume and consequently increases in blood pressure. Therefore, it is the purpose of this review to discuss the role of sodium-coupled acid-base transporters in regulating proximal tubular sodium retention and controlling blood pressure homeostasis. We will also focus on the capacity of local mediators;angiotensin II, cortisol, prosta-glandin and aldosterone, to regulate acid-base and blood pressure homeostasis.

关键词： Acid-Base Transporters Hypertension Proximal tubule Angiotensin II

The Effects of Insulin Resistance and Inflammation on Renal Proximal tubule Sodium Transport and Hypertension

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Open Journal of Endocrine and Metabolic Diseases 2013年第5期3卷 34-41页

作者： Shoko Horita Motonobu Nakamura Masashi Suzuki Hideomi Yamada George Seki Department of Internal Medicine The University of Tokyo Hospital Tokyo Japan

Insulin resistance, closely linked to inflammation, is recognized as a key factor in the onset and aggravation of diabetes, cardio-renal syndrome, hypertension, and obesity. In the renal proximal tubule, insulin resistance may increase renal sodium reabsorption, leading to hypertension, edema and sometimes heart failure. Recently some anti-diabetic agents have been shown to have effects on the transporters in renal proximal tubule. Because renal proximal tubule mediates about 70% of sodium reabsorption, it is quite important to clarify the function of renal proximal tubule under insulin resistance and inflammation.

关键词： Insulin Inflammation TNF-α Proximal tubule Insulin Resistance PPARγ Thiazolidinediones

Observation of the effect of cleaning the smear layer and tubule plugs with SEM

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Chinese Journal of Biomedical Engineering(English Edition) 2001年第1期10卷 44-46页

作者： YU Dan-ni1,DONG Ya-li2 1 Department of stomatology of the 2nd Hospital of Tianjin Medical University,Tianjin 300211,China 2 The Electron Microscope Center of Tianjin Medical University, Tianjin 300070,China Department of stomatology of the 2nd Hospital of Tianjin Medical University Tianjin 300211China The Electron Microscope Center of Tianjin Medical University Tianjin 300070China

To clean out the smear layer on teeth surface, and protect the teeth medulla, the experiment applied the study observing the cleanup of six groups of surface smear layer of dental caries and the tubule plugs reserving effect after using of different cavity cleansers with the help of SEM. The result implied that both the acidic preparations and chelator could clean out the smear layer on teeth surface in some way, but the later one could also reserve partial tubule plugs, which reduce the stimulation to the teeth medulla. So the chelator is better cleansers in clinical use.

关键词： SEM, smear layer, tubule plugs, cavity cleansers

MORPHOLOGICAL TRANSITION BETWEEN VESICLES AND tubuleS FOR A GLYCOPOLYMER-CONTAINING AMPHIPHILIC DIBLOCK COPOLYMER IN AQUEOUS SOLUTIONS

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Chinese Journal of Polymer Science 2001年第3期19卷 297-301页

作者： Zi-chen Li Yue Shen Yu-zeng Liang Fu-mian Li Department of Polymer Science & Engineering College of Chemistry Peking University Beijing 100871, China 北京大学北京

The morphological transition of molecular assemblies in aqueous solutions for a new amphiphilic diblock copolymer induced by changing the initial solvent conditions was studied by transmission electron microscopy (TEM). The copolymer was polystyrene(77)-b-poly[2-(beta -D-glucopyranosyloxy)ethyl acrylate (6)] (PSt(77)-b-PGEA(6)) and the solvent was a mixture of DMF and THF. PSt(77)-b-PGEA(6) yields vesicles and tubules when it is initially dissolved in THF and DMF respectively. The morphological transition between vesicles and tubules can be achieved by simply varying the amounts of THF and DMF, or changing the temperature at which the aggregates were prepared.

关键词： block copolymer amphiphile glycopolymer self-assembly tubule vesicle

STUDY ON MICROtubuleS IN SPERMIOGENESIS OF THE DOMESTIC DUCKS

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Chinese Science Bulletin 1982年第9期27卷 994-999页

作者：汪德耀黄宗平林美英陈睦传 Laboratory of Cell Biology Department of Biology Xiamen University Laboratory of Cell Biology Department of Biology Xiamen University? INTRODUCTION Ever since Sabatini improved on the fixing method for the electron microscope with glutaradehyde instead of osmic acid and permanganate potassinm the microtubules have been generally found in eukaryocytes as reported by Tilney and Heplar et al. A microtubule is a fine tubule of about 210-270 in diameter and it is an important cell organelle supporting the cells and making them move. It is said to be "the skeleton

Ⅰ. INTRODUCTION Ever since Sabatini improved on the fixing method for the electron microscope with glutaradehyde instead of osmic acid and permanganate potassinm, the microtubules have been generally found in eukaryocytes, as reported by Tilney and Heplar et al. A microtubule is a fine tubule of about 210—270 in diameter and it is an important cell organelle, supporting the cells and making them move. It is said to be 'the

关键词： tubule instead skeleton altern supporting divide exert doing sections mentioned

Effect of Different Irradiation Times on the Occlusion of Dentinal tubules When Using a Nd:YAG Laser: An <i>in Vitro</i>SEM Study

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Open Journal of Stomatology 2015年第3期5卷 72-79页

作者： Xiaoyu Guo Jinhua Yu Roger J. Smales Huifen Chen Haiyan Si Younong Wu Department of Endodontics Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China School of Dentistry Faculty of Health Sciences The University of Adelaide Adelaide Australia Institute of Stomatology Nanjing Medical University Nanjing China

Objective: To evaluate the effect of different irradiation times on the occlusion of dentinal tubules when using Nd:YAG laser. Background data: Dentin hypersensitivity is a frequent problem that has limited treatment success despite many chemical and physical therapies. Methods: Four coronal dentin disks 2 mm thick were cut with a low-speed diamond saw from four freshly extracted intact first molars. The coronal dentin surface of each disk was divided into four regions, each approximately 2 mm × 3 mm. The dentin surfaces were treated with 27% EDTA then the four regions irradiated separately in a randomized pattern with a Nd:YAG laser (120 mJ, 5 Hz), using irradiation times of 0 s, 20 s, 40 s and 60 s, representing laser energies of 0 J/cm2, 200 J/cm2, 400 J/cm2 and 600 J/cm2, respectively. SEM photomicro-graphs were taken at 1500× and 3000× to calculate the dentinal tubule orifice occlusion rates and to measure the tubule diameters, respectively. Results: For the laser irradiation times of 0 s, 20 s, 40 s and 60 s, the corresponding dentinal tubule occlusion rates were 2.05 (SD 0.29)%, 10.01 (1.71)%, 23.58 (2.51)% and 90.23 (2.24)%, respectively;and the tubule diameters were 4.18 (0.32) μm, 3.46 (0.24) μm, 1.69 (0.32) μm and 0.12 (0.02) μm, respectively. There were significant differences among all groups for both measured variables (p ≤ 0.005). Conclusions: Within the limitations of this in Vitro study, when using a Nd:YAG laser at 120 mJ and 5 Hz, an irradiation time of 60 s achieved the best sealing of the coronal dentinal tubule orifices.

关键词： Nd:YAG Laser Dentinal tubule Scanning Electron Microscope

Insights into kidney stem cell development and regeneration using zebrafish

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World Journal of Stem Cells 2016年第2期8卷 22-31页

作者： Bridgette E Drummond Rebecca A Wingert Department of Biological Sciences Center for Zebrafish ResearchCenter for Stem Cells and Regenerative MedicineUniversity of Notre Dame

Kidney disease is an escalating global health problem,for which the formulation of therapeutic approaches using stem cells has received increasing research *** complexity of kidney anatomy and function,which includes the diversity of renal cell types,poses formidable challenges in the identification of methods to generate replacement *** work using the zebrafish has revealed their high capacity to regenerate the integral working units of the kidney,known as nephrons,following acute ***,we discuss these findings and explore the ways that zebrafish can be further utilized to gain a deeper molecular appreciation of renal stem cell biology,which may uncover important clues for regenerative medicine.

关键词： Kidney Renal stem cell Renal progenitor Regeneration Nephron Blood filter Renal corpuscle tubule

CONNECTIVE TISSUE DISORDER

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外科研究与新技术 1997年第2期 126-127页

970390 Effects of methylprednis0Ione (MPS) on in-duction of apoptosis and expression of interleukin-1 B-converting enzyme(ICE) in the kidneys of MRL/Iprmice. WANG Jianzhong(王建中), et al. Dept Nephrol,General Hosp, P... 详细信息

关键词： converting interleukin 王建中 nephritis glomerular tubule

Current status of bioartificial kidney

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Journal of Biomedical Science and Engineering 2014年第3期7卷 108-111页

作者： Sung Joon Shin Department of Nephrology Dongguk University Ilsan Hospital Dongguk University Seoul South Korea

Current dialysis systems are not perfect considering the low efficacy and cumbersome process of actual practice. To overcome these shortcomings, bioartificial kidneys using renal tubule cells and wearable dialysis are promising ESRD treatments available in the near future. Toward clinical application, however, there are so many obstacles for commercial use of them. In this review, current status of bioartificial kidneys such as the renal tubule cell assist device (RAD) and wearable dialysis devices is presented with the comparison to show the advantages and disadvantages.

关键词： Bioartificial Kidney Renal tubule Cell Assist Device Wearable Dialysis

KIDNEY AND URINARY TRACT

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China Medical Abstracts(Internal Medicine) 2002年第1期19卷 36-38页