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Journal of Traditional Chinese Medicine 2019年第2期39卷 213-220页

作者： Zeng Mengnan Li Miao Zhang Li Zhang Beibei Wu Guangcao Feng Weisheng Zheng Xiaoke Department of Pharmacy Henan University of Chinese Medicine Department of Pharmacy Henan University of Chinese Medicine Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province

OBJECTIVE: To study the meridian tropism(MT) for three Chinese medicines: Tinglizi(Semen Lepidii Apetali, TLZ), Yiyiren(Semen Coicis, YYR), Cheqianzi(Semen Plantaginis, CQZ) in vivo ***: The extracts of TLZ,YYR, CQZ were orally administered to rats at a dose 234, 700 and 350 mg/kg, respectively. The urinary excretion rate, loss in weight of rats and the electrolyte levels in the plasma were measured, in order to assess the mechanisms of the three traditional Chinese diuretic ***: TLZ, YYR and CQZ exhibited obvious diuretic effect and reduced the weight of saline-loaded animals. All the three diuretic medicines differentially reduced various serum, urinary, lung, stomach, kidney and hormonal markers, thus indicating the different mechanisms of action and a close resemblance with their different meridian as per the MT ***: Our findings suggest that the three Traditional Chinese Medicine(TCM) medicines-TLZ,YYR and CQZ-possess different Shamisen *** can support the regimen of treating the same disease with different therapies in TCM theory.

关键词： Medicine,Chinese traditional Diuretics Meridian tropism

Investigation of the differences between the “COLD” and “HOT” nature of Coptis chinensis Franch and its processed materials based on animal’s temperature tropism

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Science China(Life Sciences) 2009年第11期52卷 1073-1080页

作者： ZHOU CanPing1,2, WANG JiaBo1, ZHANG XueRu1,2, ZHAO YanLing1, XIA XinHua2, ZHAO HaiPing1, REN YongShen1 & XIAO XiaoHe1 1 China Military Institute of Chinese Meteria Medica, 302 Military Hospital of China, Beijing 100039, China 2 College of Pharmaceutical Sciences, Hunan University of Chinese Medicine, Changsha 410208, China China Military Institute of Chinese Meteria Medica 302 Military Hospital of China Beijing China College of Pharmaceutical Sciences Hunan University of Chinese Medicine Changsha China

The description and differentiation of the so-called "Cold" and "Hot" natures, the primary "Drug Naure" of Chinese medicine, is the focus of theoretical research. In this study, the divergency between the "Cold" and the "Hot" natures was investigated through examining the temperature tropism of mice affected by Coptis chinensis Franch and its processed materials by using a cold/hot plate differentiating technology. After exposure to C. chinensis Franch, the macroscopic behavioral index of the remaining rate (RR) on a warm pad (40℃ ) significantly increased (Ptropism. The internal indexes of adenosine triphosphatase (ATPase) activity and oxygen consuming volume decreased significantly (Ptropism might reflect the internal Cold nature of C. chinensis Franch. However, the processed materials of C. chinensis Franch exhibited a different Cold nature in temperature tropism compared with crude C. chinensis Franch (CC): the Cold nature of bile-processed C. chinensis Franch (BC) enhanced while the ginger-processed C. chinensis Franch (GC) changed inversely. The changing sequence was consistent with the theoretical prognostication. It is indicated that the external Cold & Hot natures of Chinese medicine may possibly reflect in an ethological way for the changes of animal’s temperature tropism which might be internally regulated by the body’s energy metabolism.

关键词： "Cold" and "Hot" natures of Chinese medicine evaluation temperature tropism ethology drug process Coptis chinensis Franch

Tissue and host tropism of influenza viruses:Importance of quantitative analysis

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Science China(Life Sciences) 2009年第12期52卷 1101-1110页

作者： ZHANG Hong1,2 1 Z-BioMed, Inc., Rockville, MD 20855, USA 2 Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China Z-BioMed Inc. Rockville USA Department of Respiratory Medicine Affiliated Hospital of Zunyi Medical College Zunyi China

It is generally accepted that human influenza viruses preferentially bind to cell-surface glycoproteins/ glycolipids containing sialic acids in α2,6-linkage; while avian and equine influenza viruses preferentially bind to those containing sialic acids in α2,3-linkage. Even though this generalized view is accurate for H3 subtype isolates, it may not be accurate and absolute for all subtypes of influenza A viruses and, therefore, needs to be reevaluated carefully and realistically. Some of the studies published in major scientific journals on the subject of tissue tropism of influenza viruses are inconsistent and caused confusion in the scientific community. One of the reasons for the inconsistency is that most studies were quantitative descriptions of sialic acid receptor distributions based on lectin or influenza virus immunohistochemistry results with limited numbers of stained cells. In addition, recent studies indicate that α2,3- and α2,6-linked sialic acids are not the sole receptors determining tissue and host tropism of influenza viruses. In fact, determinants for tissue and host tropism of human, avian and animal influenza viruses are more complex than what has been generally accepted. Other factors, such as glycan topology, concentration of invading viruses, local density of receptors, lipid raft microdomains, coreceptors or sialic acid-independent receptors, may also be important. To more efficiently control the global spread of pandemic influenza such as the current circulating influenza A H1N1, it is crucial to clarify the determinants for tissue and host tropism of influenza viruses through quantitative analysis of experimental results. In this review, I will comment on some conflicting issues related to tissue and host tropism of influenza viruses, discuss the importance of quantitative analysis of lectin and influenza virus immunohistochemistry results and point out directions for future studies in this area, which should lead to a better understanding

关键词： tissue and host tropism influenza viruses sialic acid receptors quantitative analysis

Tissue tropism and parasite burden of Toxoplasma gondii RH strain in experimentally infected mice

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Asian Pacific Journal of Tropical Medicine 2014年第7期7卷 521-524页

作者： Yousef Dadimoghaddam Ahmad Daryani Mehdi Sharif Ehsan Ahmadpour Zahra Hossienikhah Toxoplasmosis Research Center Mazandaran University of Medical Sciences Parasitology and Mycology Department.Sari Medical School Mazandaran University of Medical Sciences Molecular and Cell Biology Research Center Mazandaran University of Medical Sciences

Objective:To evaluate parasite distribution and tissue tropism of Toxoplasma gondii tachyzoites in experimentally infected mice using real time ***:In this survey 16 Balb/c mice were inoculated with 1×10~4 alive tachyzoites of Toxoplasma gondii RH *** 1,2,3 days post infection and the last day(before death),different tissues of mice including blood,brain,eye,liver,spleen,kidney,heart and muscle were *** tissues DNA extraction,the parasite burden was quantified using real time QPCR targeting the B1 gene(451 bp).Results:It showed that Toxoplasma after intraperitoneal injection was able to movement to various tissues in24 *** burden was high in all tissues but the most number of parasites were observed in kidney,heart and liver,***:These data provide significant baseline information about Toxoplasma pathogenesis,vaccine monitoring and drug efficiency.

关键词： Parasite burden Toxoplasma gondii Tissue tropism Quantitative PCR Murine model

Hot Property of Aconiti Lateralis Radix Praeparata and its Compatibility with Zingiberis Rhizoma Based on Animal Temperature tropism

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Chinese Herbal Medicines 2012年第4期4卷 -页

作者： SUN Zhi-yong1 1. Integrative Medicine Center of 302 Military Hospital China Military Institute of Chinese Materia Medica Beijing 100039 China 2. Chengdu University of Traditional Chinese Medicine Chengdu 610075 China 3. Animal Laboratory Center 302 Hospital of PLA China

Abstract: Objective To establish an objective method for evaluating the intrinsic characteristics between hot and cold properties of herbal drugs and to study the hot property of Aconiti Lateralis Radix Praeparata (ALRP) and its compatibility with Zingiberis Rhizoma (ZR) on animal temperature tropism. Methods The equipment with cold/hot pads was used to investigate the variety of temperature tropism among mice treated by ALRP and its compatibility with ZR. Meanwhile, the activities of adenosine triphosphatase (ATPase), total anti-oxidant capability (T-AOC), and total superoxide dismutase (T-SOD) were measured. Results Compared with the homologous ALRP group, the compatibility between ALRP and ZR (AZ) had a stronger action against the decreasing of remaining rate on hot pad (P tropism. Meanwhile, the internal indexes of Na+-K+-ATPase activity, Ca2+-Mg2+-ATPase activity, and oxygen consuming volume increased significantly (P tropism and the internal activity of energy metabolism and anti-oxidant might reflect the internal hot property in an intuitive and objective way. The changes of ATPase activity of liver tissue might be the mechanism of drug action.

关键词： Key words: Aconiti Lateralis Radix Praeparata animal temperature tropism clustering analysis compatibility Zingiberis Rhizoma

Facet orientation and tropism:Associations with asymmetric lumbar paraspinal and psoas muscle parameters in patients with chronic low back pain

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Facet orientation and tropism:Associations with asymmetric l...

Active constituents and mechanisms of Respiratory Detox Shot, a traditional Chinese medicine prescription, for COVID-19 control and prevention: Network-molecular docking-LC–MS^E analysis

2016年浙江省骨科学学术年会

作者： Xu Wenbin chen shuai fan shunwu zhao fengdong yu xiaojing hu zhijun Sir Run Run Shaw Hospital

OBJECTIVE:To analyze the associations between facet orientation and tropism,and parameters of paraspinal muscles in patients with chronic low back ***:Ninety-five patients with chronic low back pain were consecutively *** facet joint angles were measured on computed tomography(CT) while gross cross-sectional area(GCSA),functional cross-sectional area(FCSA) and T2 signal intensity of lumbar paraspinal and psoas muscle were evaluated on magnetic resonance imaging(MRI).RESULTS:The GCSA and FCSA were significantly smaller for multifidus muscle(Ptropism group than those in no facet tropism group(P= 0.009 and P= 0.019).CONCLUSIONS:Muscular asymmetries may develop in the lumbar region of the spine,which are associated with facet asymmetry in patients with chronic low back *** studies are needed to understand the causal relationship between facet orientation and tropism and muscular asymmetry in future.

关键词： Facet orientation multifidus tropism cross-sectional area magnetic resonance imaging

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Journal of Integrative Medicine 2020年第3期18卷 229-241页

作者： Zi-jia Zhang Wen-yong Wu Jin-jun Hou Lin-lin Zhang Fei-fei Li Lei Gao Xing-dong Wu Jing-ying Shi Rong Zhang Hua-li Long Min Lei Wan-ying Wu De-an Guo Kai-xian Chen Lewis A.Hofmann Zhong-hua Ci Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China World Health Science Organization LeesburgVA 20176USA

Objective: Lung-toxin Dispelling Formula No. 1, referred to as Respiratory Detox Shot(RDS), was developed based on a classical prescription of traditional Chinese medicine(TCM) and the theoretical understanding of herbal properties within TCM. Therapeutic benefits of using RDS for both disease control and prevention, in the effort to contain the coronavirus disease 2019(COVID-19), have been shown. However,the biochemically active constituents of RDS and their mechanisms of action are still unclear. The goal of the present study is to clarify the material foundation and action mechanism of ***: To conduct an analysis of RDS, an integrative analytical platform was constructed, including target prediction, protein–protein interaction(PPI) network, and cluster analysis;further, the hub genes involved in the disease-related pathways were identified, and the their corresponding compounds were used for in vitro validation of molecular docking predictions. The presence of these validated compounds was also measured in samples of the RDS formula to quantify the abundance of the biochemically active constituents. In our network pharmacological study, a total of 26 bioinformatic programs and databases were used, and six networks, covering the entire Zang-fu viscera, were constructed to comprehensively analyze the intricate connections among the compounds-targets-disease pathways-meridians of ***: For all 1071 known chemical constituents of the nine ingredients in RDS, identified from established TCM databases, 157 passed drug-likeness screening and led to 339 predicted targets in the constituent–target network. Forty-two hub genes with core regulatory effects were extracted from the PPI network, and 134 compounds and 29 crucial disease pathways were implicated in the target–constitu ent–disease network. Twelve disease pathways attributed to the Lung–Large Intestine meridians, with six and five attributed to the Kidney–Urinary Bladder and Stomach–Spleen meridian

关键词： Lung-toxin Dispelling Formula No.1 COVID-19 3C-like protease Network pharmacology Molecular docking Meridian tropism

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人文学科的发展取向

Computational Geometric Analysis for <i>C. elegans</i>Trajectories on Thermal and Salinity Gradient

社会科学总论 2000年第3期 19-22页

作者：祝青山

当今社会，科学技术的第一生产力属性更为明显，并且我国正处于由计划经济向社会主义市场经济过渡时期，人们更为关注切身的物质利益，而人文学科所关注的主要是人类的信仰、情感、道德等精神文化现象，不能为社会带来直接的物质利益，... 详细信息

当今社会，科学技术的第一生产力属性更为明显，并且我国正处于由计划经济向社会主义市场经济过渡时期，人们更为关注切身的物质利益，而人文学科所关注的主要是人类的信仰、情感、道德等精神文化现象，不能为社会带来直接的物质利益，于是人们便在不同程度上产生这样一种认识：人文学科在很大程度上只不过是空洞的理论。为了人文学科的繁荣发展和人文精神的弘扬光大，本文拟从以下四个方面探讨人文学科的发展取向问题：一、为科技发展提供必要的文化氛围；二、为科技发展提供合理的价值导向；三、拓展科学家的思维，启迪科学家的智慧，激励科学家的思想；四、关注科技进展，服务重大决策，实现自我更新和完善。

关键词：人文学科发展取向文化环境价值导向 Humanities The Developmental tropism Circumstance ofculture Value judgment

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American Journal of Computational Mathematics 2020年第4期10卷 578-590页

作者： Yuetan Chu The Department of Physics University of Science and Technology of China Hefei China

Elegans are one of the best model organisms in neural researches, and tropism movement is a typical learning and memorizing activity. Based on one imaging technique called Fast Track-Capturing Microscope (FTCM), we investigated the movement regulation. Two movement patterns are extracted from various trajectories through analysis on turning angle. Then we applied this classification on trajectory regulation on the compound gradient field, and theoretical results corresponded with experiments well, which can initially verify the conclusion. Our breakthrough is performed computational geometric analysis on trajectories. Several independent features were combined to describe movement properties by principal composition analysis (PCA) and support vector machine (SVM). After normalizing all data sets, no-supervising machine learning was processed along with some training under certain supervision. The final classification results performed perfectly, which indicates the further application of such computational analysis in biology researches combining with machine learning.

关键词： C. elegans tropism Trajectories Classification Computational Geometric Analysis PCA

A Botanist’s Cognitive View on Plant Growth: Cross-Talk between Developmental and Sensitivity Networks

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American Journal of Plant Sciences 2016年第15期7卷 2307-2322页

作者： Dhananjay K. Pandey Bhupendra Chaudhary School of Biotechnology Gautam Buddha University Greater Noida India

An alteration in plant phenotypes assisted by their responses to the environmental stimuli (=tropism) has been fundamental to understand the “plant sensitivity ” that plays a crucial role in plants’ adaptive success. Plants succeed through the deployment of moderators controlling polar auxin-transport determining organ bending. Stimulus-specific effectors can be synthesized by the outer peripheral cells at the bending sites where they target highly conserved cellular processes and potentially persuade the plant sensitivity at large. Remarkably, the peripheral cells require different time-intervals to achieve the threshold expression-levels of stimulus-specific molecular responders. After stimulus perception, tropic curvatures (especially at growing root-apices) are duly coordinated via integrated chemical and electrical signalling which is the key to cellular communications. Thus, the acquired phenotypic alterations are the perplexed outcome of plant’s developmental pace, complemented by the sensitivity. A novel aspect of this study is to advance our understanding of plant developmental-programming and the extent of plant-sensitivity, determining the plant growth and their future applications.

关键词： tropism Anisotropy Plant Development Polar Auxin Transport Phototropic Response Gravitropic Response