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Roots extracts of Adenophora triphylla *** improve obesity in 3T3-L1 adipocytes and high-fat diet-induced obese mice

Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 879-886页

作者： Dong-Ryung Lee Young-Sil Lee Bong-Keun Choi Hae Jin Lee Sung-Bum Park Tack-Man Kim Han Jin Oh Seung Hwan Yang Joo-Won Suh NutraPham Tech Center for Nutraceutical and Pharmaceutical Materials Myongji University Interdisciplinary Program of Biomodulation Myongji University DONG IL Pharmtec Department of Family Medicine.VIEVIS NAMUH Hospital

Objective:To investigate the anti-obesity activity and the action mechanism of the roots of Adenophora triphylla *** extract(ATE) in high-fat diet(HFD)-induced obese mice and 3T3-LI ***:The roots of Ademption triphylla were extracted with 70%*** demonstrate the compounds,linoleic acid was analyzed by using gas chromatography:and the anti-obesity effects and possible mechanisms of ATE were examined in 3T3-L1 adipocytes and HFD-induced obese ***:Treatment with ATE inhibited the lipid accumulation without cytotoxicity in 3T3-L1 ***,200 and 400 mg/kg ATE treatment significantly decreased the body weight gain,white adipose tissues(WATs) weight and plasma triglyceride level,while 100 and 200 mg/kg ATE treatment increased the plasma high-density lipoprotein cholesterol level in the HFD-induced obese mice,as compared with the HFD *** with 200 and 400 mg/kg ATE also lowered the size of adipocytes in adipose tissue and reduced the lipid accumulation in *** treatment showed significantly lower expression level of adipogenesis-relatcd proteins,such as peroxisome proliferator-activated receptor y,fatty acid binding protein(aP2),fatty acid synthase in 3T3-L1 adipocytes;and furthermore,decreased peroxisome proliferatoractivated receptor γ,aP2,fatty acid synthase,sterol regulatory element binding protein-1c,and lipoprotein lipase mRNA expression levels in WAT of the HFD-induced obese ***:These results suggested that the ATE has an anti-obesity effect,which may be elicited by regulating the expression of adipogenesis and lipogenesis-related genes and proteins in adipocytes and WAT of the HFD-induced obese mice.

关键词： Roots of Adenophora triphylla var. japonica extrac

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Coastal Adaptation of Adenophora triphylla var. japonica(Campanulaceae)

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American Journal of Plant Sciences 2013年第3期4卷 596-601页

作者： Kyohei Ohga Miwako Muroi Hiroshi Hayakawa Jun Yokoyama Katsura Ito Shin-Ichi Tebayashi Ryo Arakawa Tatsuya Fukuda Faculty of Agriculture Kochi University Kochi Japan Faculty of Agriculture Kochi University Kochi Japan. Faculty of Science Yamagata University Yamagata Japan. Graduate School of Integrated Arts and Sciences Kochi University Kochi Japan Graduate School of Integrated Arts and Sciences Kochi University Kochi Japan.

The comparative morphology and anatomy of leaves between the coastal ecotype and the normal type of Adenophora triphylla (Thunb.) ***. var. japonica (Regel) *** (Campanulaceae) were examined to clarify the differences in morphological characters between the 2 groups. Morphological and anatomical analyses revealed that the coastal ecotype had a thicker leaf than the normal type, because of the increased size of epidermal and spongy cells. Thus, the main morphological change from the normal type into the coastal ecotype of A. triphylla var. japonica is the increase in leaf size, suggesting that the coastal ecotype may have evolved from the normal type via a heterochronic process.

关键词： Adaptation Adenophora triphylla var. japonica Coastal Ecotype Heterochronic Leaf Thickness

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Comparative Morphology and Anatomy of Non-Rheophytic and Rheophytic Types of Adenophora triphyllavar. Japonica(Campanulaceae)

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American Journal of Plant Sciences 2012年第6期3卷 805-809页

The morphology and anatomy of leaves of rheophytic and non-rheophytic types of Adenophora triphylla (Thunb.) ADC var. japonica (Regel) H. Hara were compared in order to clarify how leaf characteristics differ. Our results revealed that the leaf of the rheophytic type of A. triphylla var. japonica was narrower than the leaf of the non-rheophytic type because of fewer cells that were also smaller. Moreover, surprisingly, the rheophytic ecotype of A. triphylla var. japonica was thinner than that of the non-rheophytic type, although the general tendency is that the rheophytic leaf is thicker than the closely related non-rheophytic species, suggesting that the rheophytic type of A. triphylla var. japonica adapts differently, as compared to other rheophytic plants, to solar radiation and evaporation.

关键词： Rheophyte Leaf Ecotype Adenophora triphylla var. Japonica

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