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Sirtuin 1 in rat orthotopic liver transplantation:An I GL-1 preservation solution approach

World Journal of Gastroenterology 2015年第6期21卷 1765-1774页

作者： Eirini Pantazi Mohamed Amine Zaouali Mohamed Bejaoui Emma Folch-Puy Hassen Ben Abdennebi Ana Teresa Varela Anabela Pinto Rolo Carlos Marques Palmeira Joan Roselló-Catafau Experimental Hepatic Ischemia Reperfusion Unit Institute of Biomedical Research of Barcelona Faculty of Pharmacy Molecular Biology and Anthropology Applied to Development and Health Department of Life Sciences and Center for Neuroscience and Cell Biology University of Coimbra Department of Biology University of Aveiro

AIM:To investigate the possible involvement of Sirtuin1(SIRT1)in rat orthotopic liver transplantation(OLT),when Institute Georges Lopez 1(IGL-1)preservation solution is enriched with trimetazidine(TMZ).METHODS:Male Sprague-Dawley rats were used as donors and *** were stored in IGL-1 preservation solution for 8h at 4℃,and then underwent OLT according to Kamada’s cuff technique without *** another group,livers were stored in IGL-1 preservation solution supplemented with TMZ,at10-6 mol/L,for 8 h at 4℃and then underwent *** were sacrificed 24 h after reperfusion,and liver and plasma samples were *** injury(transaminase levels),mitochondrial damage(glutamate dehydrogenase activity)oxidative stress(malondialdehyde levels),and nicotinamide adenine dinucleotide(NAD+),the cofactor necessary for SIRT1 activity,were determined by biochemical ***1 and its substrates(acFox O1,ac-p53),the precursor of NAD+,nicotinamide phosphoribosyltransferase(NAMPT),as well as the phosphorylation of adenosine monophosphate activated protein kinase(AMPK),p-m TOR,p-p70S6K(direct substrate of m TOR),autophagy parameters(beclin-1,LC3B)and MAP kinases(p-p38 and p-ERK)were determined by Western ***:Liver grafts preserved in IGL-1 solution enriched with TMZ presented reduced liver injury and mitochondrial damage compared with those preservedin IGL-1 solution *** addition,livers preserved in IGL-1+TMZ presented reduced levels of oxidative *** was consistent with enhanced SIRT1 protein expression and elevated SIRT1 activity,as indicated by decreased acetylation of p53 and Fox *** elevated SIRT1 activity in presence of TMZ can be attributed to the enhanced NAMPT protein and NAD+/NADH ***-regulation of SIRT1 was consistent with activation of AMPK and inhibition of phosphorylation of m TOR and its direct substrate(p-p70S6K).As a consequence,autophagy mediators(beclin-1 and LC3B)were ***,MAP kinases w

关键词： Sirtuin 1 Ischemia-reperfusion injury Liver transp

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Prognostic value of ^(18)F-FDG PET/CT in liver transplantation for hepatocarcinoma

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World Journal of Gastroenterology 2015年第10期21卷 3049-3054页

作者： Olivier Detry Laurence Govaerts Arnaud Deroover Morgan Vandermeulen Nicolas Meurisse Serge Malenga Noella Bletard Charles Mbendi Anne Lamproye Pierre Honoré Paul Meunier Jean Delwaide Roland Hustinx Department of Abdominal Surgery and transplantation CHU LiegeB4000 LiegeBelgium Department of Nuclear Medicine CHU Liege University of Liege ULg CHU B4000 LiegeBelgium Department of Radiology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium Department of Pathology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium Department of Hepato-Gastroenterology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium

AIM:To evaluate the prognostic value of pretreatment F D G p o s i t r o n e m i s s i o n t o m o g ra p h y c o m p u t e d tomography(PET-CT) in patients with hepatocarcinoma treated by liver transplantation(LT).METHODS:The authors retrospectively analyzed the data of 27 patients(mean age 58 ± 9 years) who underwent FDG PET-CT before LT for *** follow-up was 26 ± 18 *** FDG PET/CT was performed according to a standard clinical protocol:4 MBq FDG/kg body weight,uptake 60 min,low-dose non-enhanced *** authors measured the SUVmax and SUVmean of the tumor and the normal *** tumor/liver activity ratios(RSUVmax and RSUVmean) were tested as prognostic factors and compared to the following conventional prognostic factors:MILAN,CLIP,OKUDA,TNM stage,alphafoetoprotein level,portal thrombosis,size of the largest nodule,tumor differentiation,microvascular invasion,underlying cirrhosis and liver ***:Overall and recurrence free survivals were80.7%and 67.4%at 3 years,and 70.6%and 67.4%at 5 years,*** to a multivariate Cox model,only FDG PET/CT RSUVmax predicted recurrence free *** though the MILAN criteria alone were not predictive,it is worth noting that none of the patients outside the MILAN criteria and with RSUVmax<1.15 ***:FDG PET/CT with an RSUVmax cutoff value of 1.15 is a strong prognostic factor for recurrence and death in patients with HCC treated by LT in this retrospective *** prospectivestudies should test whether this metabolic index should be systematically included in the preoperative assessment.

关键词： Cancer Hepatoma Hepatocellular cancer Liver transp

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China Strengthens Administration on the transportation of Dangerous Chemicals

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China Chemical Reporter 2008年第14期19卷 12-12页

"Through the revision to regulations on dangerous goods,the Chinese government has made a clearer elassification of dangerous goods and issued a series of policies to ensure the safe transportation of dangerous goods,... 详细信息

关键词： dangerous goods regulations issued revision transp

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铁路新老兵运输工作开始

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报林 2010年第12期 18-18页

作者：蔡冰

今年退伍老兵运输从11月25日开始,入伍新兵运输从12月10日开始,均至12月底结束。各铁路局成立新老兵运输领导小组和办公室,充分做好各项准备工作,确保计划落到实处,力争高标准、高质量地做好新老兵运输工作。完善新老兵运输工作责任制... 详细信息

今年退伍老兵运输从11月25日开始,入伍新兵运输从12月10日开始,均至12月底结束。各铁路局成立新老兵运输领导小组和办公室,充分做好各项准备工作,确保计划落到实处,力争高标准、高质量地做好新老兵运输工作。完善新老兵运输工作责任制度。相关部门加大退伍老兵运输组织力度,预留充足的票额、车辆。各客运段添乘担当有新老兵运输任务的列车,确保新老兵运输安全平稳。

关键词：新老兵运输运输组织退伍老兵 railway 入伍新兵工作责任制度领导小组添乘 transp

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