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Fabrication of deoxycholic acid-modified polymeric micelles and their transmembrane transport

Journal of Chinese Pharmaceutical Sciences 2021年第1期30卷 17-26页

作者： Qi Liu Leqi Wang Xinping Hu Chuhang Zhou Yingwei Tang Yining Ma Xiaoxiao Wang Yan Liu Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China

Oral administration is the best way for the most patients due to the good compliance,and intestinal epithelium is the main barrier of oral drug *** order to overcome the small intestine epithelial barrier to orally deliver water-insoluble drugs,deoxycholic acid(DA),a substrate of the intestinal bile acid transporters,conjugated poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)(DA-PEOz-PLA)was designed and synthesized,and deoxycholic acid-modified polymeric micelles composed of DA-PEOz-PLA and mPEG-PLA were fabricated to encapsulate model drug coumarin 6(C6)based on intestinal bile acid *** structure of DA-PEOz-PLA was confirmed using 1 H NMR and TLC,and the molecular weight measured by GPC was 10034 g/mol with a PDI of *** C6-loaded polymeric micelles with drug loading content of 0.085%were characterized to have 40.11 nm in diameter and uniform spherical morphology observed by ***,the deoxycholic acid-modified polymeric micelles were demonstrated to further enhance the transmembrane transport *** mechanic study evidenced that anchorage of deoxycholic acid onto the micelles surface enriched their transcellular transport ***,the designed deoxycholic acid-modified polymeric micelles might have a promising potential for oral delivery of water-insoluble drugs.

关键词： Deoxycholic acid Intestinal bile acid transporter Polymeric micelles Oral nano drug delivery system transmembrane transport

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transmembrane transport characterization across ionic redox transistors using surface-tracked scanning ion conductance microscopy

Advanced Sensor and Energy Materials

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Advanced Sensor and Energy Materials 2022年第3期1卷 17-23页

作者： Vijay Venkatesh Travis Hery Vishnu Baba Sundaresan Department of Mechanical and Aerospace Engineering The Ohio State University201 W 19th AveColumbusOH43210USA

A fundamental understanding of ion transport at the nanoscale is critical to the development of efficient chemical separation membranes,catalysts,ionic/bio-inspired materials,and its scale up into multi-functional ionic *** imaging using scanning probe microscopy hardware has provided a method to visualize and understand processes that occur at the surface of ionic active *** suite of scanning probe microscopy techniques developed over the last few years are limited to imaging surface-level phenomena and have not been applied to investigate transmembrane properties of synthetic and natural membranes with high spatial and temporal *** this article,we demonstrate the application our recently developed‘surface-tracked scanning ion conductance microscopy’technique to characterize voltage-regulated ion transport in an ionic redox *** ionic redox transistor exhibits controlled transmembrane ion transport as a function of its electrochemical redox *** technique presented in this article uses shear force measured between the nanopipette and ionic substrate to image topography of the porous substrate and simultaneously characterize topography-correlated transmembrane transport through the ionic redox *** transmembrane conductance measured across an array of pores within the ionic redox transistor varies from 0.004μS/cm(OFF state)to 0.015μS/cm(ON state).We anticipate that the spatial correlation of transmembrane ion transport in the ionic redox transistor would result in a scale up into smart membrane separators for energy storage,neuromorphic circuits,and desalination membranes.

关键词： Ionic redox transistor Shear-force transmembrane transport Scanning ion conductance microscopy

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Unimolecular artificial transmembrane channel with terminal dihydrogen phosphate groups showing transport selectivity for ammonium

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Chinese Chemical Letters 2020年第1期31卷 77-80页

作者： Jian-Yu Chen Qi Xiao Harekrushna Behera Jun-Li Hou Department of Chemistry Fudan University

A new artificial transmembrane channel molecule bearing dihydrogen phosphate groups has been *** terminal dihydrogen phosphate groups enable the channel to be highly negatively charged at both ends of the channel *** artificial channel could incorporate into the lipid bilayer efficiently under low *** channel displays high NH4+/K+selectivity due to the electrostatic interaction and hydrogen bonding between NH4+and the terminal dihydrogen phosphate groups.

关键词： Artificial transmembrane channel Ammonium transport Dihydrogen phosphate Pillararene transmembrane transport transport selectivity

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Responsive Polymers with Contraction-arisen Helicity and Biomimetic Membrane-spanning transport Functions

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Chemical Research in Chinese Universities 2022年第3期38卷 803-808页

作者： MIN Jing ZHANG Chenyang QI Shuaiwei WANG Liyan DONG Zeyuan State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012P.R.China

Responsive polymers have attracted increasing attention for prospective design of smart *** development of multifunctional responsive materials is very dependent on polymeric structures that can be manipulated with the change of microenvironment at the molecular ***,we report a type of responsive coordination polymers(RCPs)consisting of dual phenanthroline-oxadiazole(DPO)units and metal Zn^(2+)ions,which can contract from linear structure into topologically helical structure driven by hydrophobic effect while changing the microenvironment from nonpolar solvent to aqueous *** symmetry breaking of RCPs was confirmed by circular dichroism(CD)spectra and atomic force microscope(AFM)images,clearly demonstrating the intramolecularly contraction-arisen ***,RCPs can intelligently adapt different microenvironments by changing their conformations,as evidenced by a demonstration of biomimetic lipid bilayer-based vesicle ***,RCPs show significant concentration-dependent transmembrane transport functions,implying that RCPs are able to span cellular membranes to form channels inside the hydrophobic lipid *** the same time,the electrophysiological conductance experiments further underpin the biomimetic transport functions and channel-based conduction mechanism of *** study demonstrates an important paradigm of responsive polymers performing microenvironment-induced conformational change and thereof unique functions,and thus provides valuable insights on the development of functional responsive materials.

关键词： Responsive polymer Molecular contraction Symmetry breaking Helicity transmembrane transport

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Controlling microbiological interfacial behaviors of hydrophobic organic compounds by surfactants in biodegradation process

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Frontiers of Environmental Science & Engineering 2014年第3期8卷 305-315页

作者： Dong ZHANG Department of Environmental Science Zhcjiang University Hangzhou 310058. China Zhejiang Provincial Key Laboratory of Organic Pollution Process and Control Hangzhou 310058 China

Bioremediation of hydrophobic organic compounds （HOCs） contanlinated soils involves several physicochemical and microbiological interracial processes among the soil-water-microorganism interfaces. The participation of surfactants facilitates the mass transport of HOCs in both the physicochemical and microbiological interfaces by reducing the interfacial tension. The effects and underlying mechanisms of surfactants on the physi-cochemical desorption of soil-sorbed HOCs have been widely studied. This paper reviewed the progress made in understanding the effects of surfactant on microbiological interlhcial transport of HOCs and the underlying mechanisms, which is vital for a better understanding and control of the mass transfer of HOCs in the biodegradation process. In summary, surfactants affect the microbiological interfacial behaviors of HOCs during three consecutive processes： the soil solution-microorganism sorption, the transmembrane process, and the intracellular metabolism. Surfactant could promote cell sorption of HOCs depending on the compatibility of surfactant hydrophile hydrophilic balance （HLB） with cell surface properties; while the dose ratio between surfactant and biologic mass （membrane lipids） determined the transmembrane processes. Although surfactants cannot easily directly affect the intracellular enzymatic metabolism of HOCs due to the steric hindrace, the presence of surfactants can indirectly enhanced the metabolism by increasing the substrate concentrations.

关键词： biodegradation sorption transmembrane transport microbiological interfaces surfactants

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Physical principles at bio-nano interfaces with active matter

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National Science Open 2024年第4期3卷 83-105页

作者： Xueqing Jin Haixiao Wan Zheng Jiao Jiaqi Li Li-Tang Yan State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Active matter is characterized by out-of-equilibrium behaviors,offering an attractive,alternative route for revolutionizing disease diagnostics and therapy.A better understanding of how active matter interacts with cell membranes is critical to elucidating the underlying physical mechanisms and broadening the potential biomedical *** review provides a conceptual framework on the physiochemical mechanisms underlying active matter-biomembrane *** briefly introduce the physical models of active matter and lipid membranes,and summarize the typical phenomena emerging from various active matter,including artificial active particles,cellular cytoskeletons,bacteria,and membrane ***,the remaining challenges and future perspectives of such non-equilibrium systems in living organisms are *** findings and fundamental principles discussed in this review shed light on the rational design of activity-mediated cellular interaction,and could trigger better strategies to design and develop novel functional systems and materials toward advantageous biomedical applications.

关键词： active matter cell membrane bio-nano interfaces nonequilibrium physics transmembrane transport

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