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TMEM158 May Serve as a Diagnostic Biomarker for Anaplastic Thyroid Carcinoma:An Integrated Bioinformatic Analysis

Current Medical Science 2020年第6期40卷 1137-1147页

作者： Han-ning LI Ya-ying DU Tao XU Rui ZHANG Ge WANG Zheng-tao LV Xing-rui LI Department of Thyroid and Breast Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Anaplastic thyroid carcinoma(ATC)is a rare but extremely lethal ***,little is known about the pathogenesis of *** its high mortality,it is critical to improve our understanding of ATC pathogenesis and to find new diagnostic *** the present study,two gene microarray profiles(GSE53072 and GSE65144),which included 17 ATC and 17 adjacent non-tumorous tissues,were *** analyses were then ***(IHC)and receiver operating characteristic(ROC)curves were then used to detect transmembrane protein 158(TMEM158)expression and to assess diagnostic sensitivity.A total of 372 differentially expressed genes(DEGs)were *** protein-protein interaction(PPI)analysis,we identified a significant module with 37 upregulated *** of the genes in this module were related to cell-cycle *** co-expression analysis,132 hub genes were selected for further *** genes were identified as both DEGs and genes of interest in the weighted gene co-expression network analysis(WGCNA).IHC and ROC curves confirmed that TMEM158 was overexpressed in ATC tissue as compared with other types of thyroid cancer and normal tissue *** identified 8 KEGG pathways that were associated with high expression of TMEM158,including aminoacyl-tRNA biosynthesis and DNA *** results suggest that TMEM158 may be a potential oncogene and serve as a diagnostic indicator for ATC.

关键词： anaplastic thyroid carcinoma transmembrane protein 158 bioinformatics weighted gene co-expression network analysis gene set enrichment analysis

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