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Cellular Localization of Rice SUMO/SUMO Conjugates and in vitro Sumoylation Using Rice Components

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Rice science 2020年第1期27卷 1-4页

作者： Joungsu JOO Dong Hee CHOI Sang Hyon KIM Sang Ik SONG Department of Bioscience and Bioinformatics Myongji University

Many proteins are regulated by post-translational modifications,such as the reversible covalent attachment of ubiquitin and ubiquitin-like proteins in eukaryotes(Kerscher et al, 2006). Post-translational modification of proteins by the SUMO protein family is involved in diverse cellular processes, including development, hormonal responses, and biotic and abiotic stress signaling(Park et al, 2011). SUMO modification can modulate protein-protein interactions, intracellular localization or the activities of the protein(Gareau and Lima, 2010).

关键词： SUMO modification translational

New Approach for Efficient Synthesis of Complex Glycopeptides in Liquid Phase

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Bulletin of the Chinese Academy of Sciences 2022年第2期36卷 114-115页

作者： DIAO Wentong Shanghai Institute of Materia Medica Chinese Academy of Sciences

Protein glycosylation,one of the most common post-translational modifications,is implicated in the occurrence and development of many diseases.The biological functions of glycopeptides are realized by the collaborative effects of both the sugar structure and peptide sequence.However,due to the complexity and diversity of glycopeptides,it is difficult to obtain a wide range of structurally well-defined glycopeptides for biofunctional studies and development of glycopeptide-based drugs.

关键词： sugar structurally translational

Genetically encoded fluorescent biosensor of histone 3 lysine 79 in MEFs

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医用生物力学 2013年第S1期28卷 118-121页

作者： Qin Peng Yuanliang Wang Yingxiao Wang Department of Bioengineering University of California Bioengineering College Chongqing University

Introduction Post-translational modifications of core histones have emerged as a critical player in dynamical regulation of gene expression and accurate chromatin structures[1-2].In recent years it has been demonstrated that,histone lysine methylation is particularly prominent as one of the most important epigenetic modifications during cell cycles,development and differentiation,and in response to external stimuli,e.***.exogenous growth factors and mechanical stimulation.This epigenetic modification may also be an early event that regulates the gene expression dur-

关键词： biosensor lysine translational methylation histone dynamical stimulation encoded epigenetic exogenous

对英文科技期刊约稿的初浅认识和尝试--以Journal of translational Neuroscience为例

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首都医科大学学报 2016年第5期37卷 711-714页

作者：庄颖张建军张俊敏《首都医科大学学报》编辑部北京100069 Journal of translational Neuroscience编辑部北京100069 《医学教育管理》编辑部北京100069

目的作为一本新创的英文期刊,Journal of translational Neuroscience杂志需要尽快提升其学术水平,扩大其社会影响力,以期能迅速在国际专业学术期刊界占有一席之地,通过约稿获得高质量的学术论文就显得至关重要。方法笔者从找准期刊学... 详细信息

目的作为一本新创的英文期刊,Journal of translational Neuroscience杂志需要尽快提升其学术水平,扩大其社会影响力,以期能迅速在国际专业学术期刊界占有一席之地,通过约稿获得高质量的学术论文就显得至关重要。方法笔者从找准期刊学术定位、采取灵活多样的约稿方式、分析解决约稿过程中可能存在的问题以及如何做好约稿后续服务工作等几个方面入手,初浅分析探讨了关于期刊约稿的方式方法。结果通过期刊定位准确锁定目标作者群,依托自身优势资源,参与学术会议,通过编委约稿以及提供优质的后续服务等方法获得稳定的高质量作者群,从而获得持续的优秀稿源。结论拥有持续的高质量稿件是促使期刊进入良性循环的重要保障,通过约稿可以解决新创办的期刊无稿可用和缺少优秀稿件的难题,推动期刊走出困境,渐入正轨。

关键词： Journal of translational Neuroscience 英文科技期刊约稿对策与方法

Lab-to-clinic application of stem cell therapy for stroke

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Chinese Neurosurgical Journal 2016年第4期2卷 219-222页

作者： Mia C.Borlongan Sonya Kong David C.Hess Center of Excellence for Aging and Brain Repair Morsani College of Medicine University of South Florida 12901 Bruce B.Downs Blvd. Tampa FL 33612 USAResearch Service at James Haley VA Hospital Tampa FL 33612USA Department of Neurology Medical College of Georgia Augusta University 1120 15th Street Augusta GA 30912 USA

Stem cell therapy or “cell therapy” has been demonstrated to be a potent treatment intervention in animal models of acute ischemic stroke, and recently has been introduced as an experimental therapy in early phase clinical trials. Among the many stem cells, the bone marrow adherent cell type known as mesenchymal stem cells have emerged in laboratory studies as a safe and effective therapy for ischemic stroke and other brain diseases. In particular, a unique population of adherent bone marrow-derived cells, called MultiStem cells, display immunomodulatory effects and are a promising allogeneic cell therapy in acute ischemic stroke. Here, we describe the preclinical evidence supporting the use of MultiStem in the acute setting of ischemic stroke and the translation into an early phase clinical trial in ischemic stroke.

关键词： Multistem Cerebral ischemia Preclinical Clinical translational

Lectin affinity-based glycoproteome analysis of the developing xylem in poplar

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Forestry Research 2022年第1期2卷 132-142页

作者： Hao Cheng Jinwen Liu Meiqi Zhou Yuxiang Cheng Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin 150040China Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection Wenzhou UniversityWenzhou 325035China

Glycosylation is a significant post-translational modification of proteins,and some glycoproteins serve as players in plant cell wall synthesis and modification.Wood is a highly developed cell wall organization,and protein glycosylation as a regulatory mechanism may be involved in wood formation.Here,a lectin affinity-based glycoproteome was performed in stem developing xylem of poplar.After enrichment,trypsin digestion,LC-MS/MS analysis and peptide identification,we identified 154 glycoproteins from poplar developing xylem,which were classified into nine functional groups mainly including protein acting on carbohydrates,oxido-reductase,proteases,and protein kinases.Further,N-and/or Oglycosylation sites of the identified proteins were analyzed using bioinformatic tools,and deglycosylation experiments in the selected PtSOD and PtHAD proteins verified the reliability of the identified glycoproteins.Analysis of protein subcellular localization showed that a total of 63%of the identified glycoproteins were extracellular proteins or located in the plasma membrane.Poplar eFP and RT-qPCR data showed that a number of the genes encoding these glycoproteins such as laccase,peroxidase and cysteine protease,have highly preferential expression profiles in the developing xylem.Together with previously published research,most identified glycoproteins could be involved in wood cell wall synthesis and modification in poplar.Thus,our study provides some potential wood formation-related glycoproteins to be determined during tree stem development.

关键词： synthesis verified translational

Oncology and translational Medicine

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Oncology and translational Medicine 2018年第1期4卷 40-40页

作者： Jun Xia Yening Wang Jing Chen Qiang Wu 不详

Oncology and translational Medicine is an international professional academic periodical.The Journal is designed to report progress in research and the latest findings in domestic and international oncology and translational medicine,to facilitate international academic exchanges,and to promote research in oncology and translational medicine as well as levels of service in clinical practice.The entire journal is published in English for a domestic and international readership.

关键词： translational Medicine published

Profile of Editor-in-Chief

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Genes & Diseases 2023年第3期10卷 I0001-I0001页

high international academic influence T.-C.He,MD,PhD,is a well-established investigator with more than 20-year-experience in basic biomedical and translational research.His research interests include cell signaling,ca... 详细信息

关键词： translational cancer interests

Oncology and translational Medicine

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Oncology and translational Medicine 2017年第6期3卷 270-270页

Oncology and translational Medicine is an international professional academic periodical. The Journal is designed to report progress in research and the latest findings in domestic and international oncology and translational medicine, to facilitate international academic exchanges, and to promote research in oncology and translational medicine as well as levels of service in clinical practice. The entire journal is published in English for a domestic and international readership.

关键词： translational Medicine The Journal is designed