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Nuclear reprogramming: the zygotic transcription program is established through an“erase-and-rebuild” strategy

Cell Research 2007年第2期17卷 117-134页

作者： Feng Sun~(1,*) Haiyan Fang~(2,*) Ruizhen Li~(2,*) Tianlong Gao~1 Junke Zheng~2 Xuejin Chen~2 Wenqin Ying~2 Hui Z Sheng~2 ~1Program for Graduation Studies,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China ~2Center for Developmental Biology,Xinhua Hospital,School of Medicine,Shanghai Jiao Tong University,1665 Long Jiang Road,Shanghai 200092,China Program for Graduation Studies Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Center for Developmental Biology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai China

Oocytes display a maternal-specific gene expression profile,which is switched to a zygotic profile when a haploidset of chromatin is passed on to the fertilized egg that develops into an *** mechanism underlying this tran-scription reprogramming is currently *** we demonstrate that by the time when transcription is shut downin germinal vesicle oocytes,a range of general transcription factors and transcriptional regulators are dissociated fromthe *** global dissociation of chromatin factors(CFs)disrupts physical contacts between the chromatin andCFs and leads to erasure of the maternal transcription program at the functional *** transcription factors andregulators remain separated from chromatin for a prolonged period,and become re-associated with chromatin shortlyafter pronuclear *** is followed temporally by the re-establishment of nuclear functions such as DNA rep-lication and *** propose that the maternal transcription program is erased during oogenesis to generatea relatively naive chromatin and the zygotic transcription program is rebuilt de novo after *** process istermed as the"erase-and-rebuild"process,which is used to reset the transcription program,and most likely other nuclearprocesses as well,from a maternal one to that of the *** further show in the accompanying paper(Gao T,et al.,Cell Res 2007:17:135-150.)that the same strategy is also employed to reprogram transcriptional profiles in somatic cellnuclear transfer and parthenogenesis,suggesting that this model is universally applicable to all forms of transcriptionalreprogramming during early *** of CFs from chromatin also offers an explanation for thephenomenon of transcription silence during the maternal to zygotic transition.

关键词： nuclear reprogramming transcription transcription silence chromatin factors embryogenesis fertilization oogenesis

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