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transcranial pulse current stimulation improves the locomotor function in a rat model of stroke

Neural Regeneration Research 2021年第7期16卷 1229-1234页

作者： Wen-Jing Wang Yan-Biao Zhong Jing-Jun Zhao Meng Ren Si-Cong Zhang Ming-Shu Xu Shu-Tian Xu Ying-Jie Zhang Chun-Lei Shan Center of Rehabilitation Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Rehabilitation Medicine The First Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Laboratory of Neurobiology Shanghai Research Institute of Acupuncture and MeridianShanghaiChina

Previous studies have shown that transcranial pulse current stimulation(tPCS) can increase cerebral neural plasticity and improve patients' locomotor ***, the precise mechanisms underlying this effect remain *** the present study, rat models of stroke established by occlusion of the right cerebral middle artery were subjected to tPCS, 20 minutes per day for 7 successive *** significantly reduced the Bederson score, increased the foot print area of the affected limbs, and reduced the standing time of affected limbs of rats with stroke compared with that before *** staining and western blot assay revealed that tPCS significantly increased the expression of microtubule-associated protein-2 and growth-associated protein-43 around the ischemic *** finding suggests that tPCS can improve the locomotor function of rats with stroke by regulating the expression of microtubule-associated protein-2 and growth-associated protein-43 around the ischemic *** findings may provide a new method for the clinical treatment of poststroke motor dysfunction and a theoretical basis for clinical application of *** study was approved by the Animal Use and Management Committee of Shanghai University of Traditional Chinese Medicine of China(approval ***190315003) on February 22, 2019.

关键词： motor function neural plasticity non-invasive brain stimulation protection repair stroke transcranial pulse current stimulation

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