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Detection of SHV genotype polymorphism of ESBL-producing Gram-negative bacterium

Detection of SHV genotype polymorphism of ESBL-producing Gra...

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第十二届全国化疗药理学术研讨会

作者： Xiaoli Ji Junlong Li Xiaohui Deng Yingfeng Zhou XiaoqingNi Xiaokang Liu Department of Pharmacology West China School of Preclinical and Forensic MedicineSichuan University College of Basic Medicine Xinxiang Medical University First Affiliated Hospital Xinxiang Medical University

Background:Extended-spectrumβ-1actamases(ESBLs)is prevalent due to the extensive usage of the extended-spectrum cephalosporins and leads to huge financial loss in the whole world while presenting a challenge to clinical ***:To delineate the frequency of occurrence of ESBL in Enterobacteriaceae from Chengdu and confirm the SHV *** and methods:A random collection of 153 Escherichia coli isolates(***)and 70 Klebsiella pneumoniae(***)isolates were *** amplification products obtained by Polymerase Chain Reaction(PCR)were *** with novel mutations were transformed to *** DH5α.The minimal inhibitory concentration(MIC)was obtained by microdilution ***:The relevance ratio of ESBL was 67.7%and the proportion of gene blawas 18.5%.A new genotype ofβ-lactamase was demonstrated,and submitted to GenBank.12 mutational sitets were found in 28 ESBL-producing isolates including four nonsense ***-rates of 28 ESBL-producing isolates to imipenem were 100%,resistant-rates to penicillin,amoxicillin,oxacillin were 100%.MIC of DH5α-F8 to penicillin,oxacillin,cefoxitin,cefotaxime,cefepime,cefoperazone/sulbactam,imipenem,netilmicin is 512,512,2,0.03,0.06,4,0.015,and 32 *** and conclusion:ESBL in Chengdu,and SHV-28 is the most prevalent *** is the most effective antibiotic to ESBL,the forth-generation cephalosporins andβ-lactamase inhibitor compound are also *** is mediated by plasmids and able to spread among different *** mutations of blaSHV gene exit in Chengdu at least from 2010.

关键词： E.coli K.pneumoniae ESBL SHV genotype mutation trans-conjugation antibiotic Sensitivity

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