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The Psychosomatic Traits of“People with the Five Elements in traditional Chinese Medicine”:A Qualitative Study

Biomedical and Environmental Sciences 2023年第11期36卷 1068-1078页

作者： LI Jia Jia YANG Xin Yu ZHANG Hong Jun YIN Dong Qing ZHANG Jin Tao CUI Jing Wen HAN Jing Dong MA Yan JIA Hong Xiao The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100088China School of Life Sciences Peking UniversityBeijing 100871China The First Hospital Affiliated to Beijing University of Chinese Medicine DongZhimen HospitalBeijing 100700China State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China

Objective To identify the representative attributes of the five elements of a person with a qualitative methodology and provide the basis for the clinical diagnosis and treatment of“people with the five elements in traditional Chinese medicine(TCM).”Methods Data collected from the literature review,two sessions of brainstorming of experts with related experience in“people with the five elements in TCM”from October 2020 to December 2020,and six rounds of in-depth interviews with 30 participants who had various attributes of the five elements from March 2021 to October 2021 were *** was used in this study,and theming and synthesizing were used to analyze the *** A total of 31 experts and 30 interviewees participated in this *** median age of the experts and interviewees were 48.0 and 38.5 years,respectively;51.66%and 54.8%of experts and interviewees,respectively,were *** descriptors of facial diagrams of“people with the five elements in TCM”were complexion,shape,distribution state of facial bones,convergence trend of facial muscles,and facial expression.A theoretical model of“people with the five elements in TCM”was shaped based on these *** The study suggests a possibility for bridging the gap between personality and bodily state,identifying an avenue for personality research from the perspective of TCM.

关键词： People with the five elements in TCM Brainstorming In-depth interviews Triangulation Personality traditional chinesemedicine

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Urgent Need to Improve the Quality of Case Report in traditional Chinese Medicine:Assessment on Reporting Quality of 3,417 Cases

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Chinese Journal of Integrative Medicine 2016年第6期22卷 473-480页

作者：付姝菲管伟曾筱茜张莉郑颂华宋丽钟丽丹林佳王永炎商洪才卞兆祥 Tianjin University of traditional Chinese Medicine Tianjin Key Laboratory of Modern Chinese Medicine--Co-constructing State Key Laboratory Breading Base by Province and the MinistryTianjin(300193)China Hong Kong Chinese Medicine Clinical Study Centre and School of Chinese Medicine Hong Kong Baptist UniversityHong Kong SARChina West China Hospital Sichuan UniversityChengdu(610041)China Second Affiliated Hospital of Tianjin University of traditional Chinese Medicine Tianjin(300150)China China Academy of Chinese Medical Sciences Beijing(100700)China Key laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100700)China

Objective： To survey the reporting quality of traditional Chinese medicine （TCM） case reports published in recent years and understand the common problems. The assessment results would lay the foundation for the development of recommendations for case report in Chinese medicine. Methods： This survey determined the reporting quality of cases with Chinese herbal decoction, Chinese proprietary medicine, acupuncture, moxibustion and other traditional therapies published in 20 core medical journals of China by searching the China Academic Journals Full-text Database from 2006 to 2010. Fifty survey items in 16 domains were used to determine the reporting quality. One point was assigned to each item （Yes=l point; _disibledevent=0 point）, and total score was 50 points. The domain of treatment was assessed independently, ranging from 2 to 9 items for different TCM interventions. Results： The total of 1,658 case reports, covering 3,417 cases were included to analyze from 13 out of 20 core medical journals of China. There were 74.8% of them did not identify the nature of study in title, while 73.9% did not comprise an abstract. Incomplete reporting was found in discussions/ comment, and only 38.9% had made recommendations or take-away messages. Figures and tables were infrequently used. Three cases cited the full names of patients, but without declaring that any consent was obtained. Over 90% reported the symptoms and signs of TCM, and characteristics on tongue and pulse, but less than 50% did mention other medical history and diagnostic rationale. More than 90% treatments of the included cases were herbal decoction, with clear reporting on the ingredients and dosages. However, the reporting rate of the dosages of each ingredient was just 48.4%. Almost none reported the quality control of crude herbs, manufacturers and lot numbers of herbal proprietary medicine. Besides, advices and precautions on diet, emotions and living were rare to be illustrated. Conclusion： Systematic reporting reco

关键词： case report traditional chinesemedicine quality assessment

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Protective effect of Radix Astragali injection on immune organs of rats with obstructive jaundice and its mechanism

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World Journal of Gastroenterology 2009年第23期15卷 2862-2869页

作者： Rui-Ping Zhang Xi-Ping Zhang Yue-Fang Ruan Shu-Yun Ye Hong-Chan Zhao Qi-Hui Cheng Di-Jiong Wu Department of Orthopaedics or Departmentof Radiology First Clinical Medical College of Shanxi MedicalUniversity Taiyuan 030001 Shanxi Province China Department of General Surgery Hangzhou First People's Hospital Hangzhou 310006 Zhejiang Province China Zhejiang Universityof traditional Chinese Medicine Hangzhou 310053 ZhejiangProvince China Department of test Hangzhou First People'sHospital Hangzhou 310006 Zhejiang Province China Department of Gynaecology and Obstetrics Hangzhou First People's Hospital Hangzhou 310006 Zhejiang Province China

AIM: To observe the protective effect of Radix Astragali injection on immune organs (lymph nodes, spleen and thymus) of rats with obstructive jaundice (OJ) and its mechanism. METHODS: SD rats were randomly divided into sham-operation group, model control group and Radix Astragali treatment group. On days 7, 14, 21 and 28 after operation, mortality rate of rats, pathological changes in immune organs, expression levels of Bax and nuclear factor (NF)-κB p65 proteins, apoptosis indexes and serum tumor necrosis factor (TNF)-α level in spleen and thymus were observed, ***: Compared to model control group, the number of dead OJ rats in Radix Astragali treatment group decreased (P > 0.05). The TNF-α level (27.62 ± 12.61 vs 29.55 ± 18.02, 24.61 ± 9.09 vs 31.52 ± 10.95) on days 7 and 21, the pathological severity score for spleen [0.0 (0.0) vs 0.0 (2.0) on days 7 and 14 and for lymph nodes [0.0 (1.0) vs 1.0 (2.0), 1.0 (0.0) vs 2.0 (1.0)] on days 21 and 28, the product staining intensity and positive rate of Bax protein in spleen [0.0 (0.0) vs 1.0 (2.0), 0.0 (1.0) vs 2.0 (1.5) and thymus [0.0 (0.0) vs 1.0 (2.0), 0.0 (1.0) vs 2.0 (1.5)] on days 14 and 28, the apoptotic indexes [0.0 (0.0) vs 0.0 (0.01)] in spleen and thymus [0.0 (0.0) vs 0.0 (0.01) on days 14 and 21 were significantly lower in Radix Astragali treatment group than in model control group (P < 0.05). CONCLUSION: Radix Astragali has protective effects on immune organs of OJ rats by relieving the pathological changes in immune organs, reducing TNF-α level and inhibiting Bax expression and apoptosis in spleen and thymus.

关键词： Radix Astragali traditional chinesemedicine Obstructive jaundice Rat Immune organ Tumor necrosis factor-α Bax Nuclear factor-κB Apoptosis Tissue microarry

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Human Gut Microbiota and Gastrointestinal Cancer

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Genomics, Proteomics & Bioinformatics 2018年第1期16卷 33-49页

作者： Changting Meng Chunmei Bai Thomas D. Brown Leroy E. Hood Qiang Tian Institute for Systems Biology Seattle WA 98109 USA Department of Oncology Peking Union Medical College Hospital Beijing 100730 China Swedish Cancer Institute Seattle WA 98104 USA P4 Medicine Institute Seattle WA 98109 USA

Human gut microbiota play an essential role in both healthy and diseased states of humans. In the past decade, the interactions between microorganisms and tumors have attracted much attention in the efforts to understand various features of the complex microbial communities, as well as the possible mechanisms through which the microbiota are involved in cancer prevention, carcinogenesis, and anti-cancer therapy. A large number of studies have indicated that microbial dysbiosis contributes to cancer susceptibility via multiple pathways. Further studies have suggested that the microbiota and their associated metabolites are not only closely related to carcinogenesis by inducing inflammation and immune dysregulation, which lead to genetic instability, but also inter- fere with the pharmacodynamics of anticancer agents. In this article, we mainly reviewed the influ- ence of gut microbiota on cancers in the gastrointestinal （GI） tract （including esophageal, gastric, colorectal, liver, and pancreatic cancers） and the regulation of microbiota by diet, prebiotics, pro- biotics, synbiotics, antibiotics, or the traditional Chinese Medicine. We also proposed some new strategies in the prevention and treatment of GI cancers that could be explored in the future. We hope that this review could provide a comprehensive overview of the studies on the interactions between the gut microbiota and GI cancers, which are likely to yield translational opportunities to reduce cancer morbidity and mortality by improving prevention, diagnosis, and treatment.

关键词： Inflammation Immune regulation Microbial metabolites Carcinogenesis traditional chinesemedicine

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A combination extract of Renshen(Panax Ginseng),Yinyanghuo(Herba Epimedii Brevicornus),Yuanzhi(Radix Palygalae) and Jianghuang(Rhizoma Curcumae Longae) decreases glycogen synthase kinase 3β expression in brain cortex of APPV717I transgenic mice

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Journal of traditional Chinese Medicine 2013年第2期33卷 211-217页

作者： Jing Shi Jinzhou Tian Xuekai Zhang Chuiyou Zeng Mingqing Wei Pengwen Wang Yongyan Wang Department of Neurology Dongzhimen HospitalBeijing University of Chinese Medicine Clinical Neuroscience Research Group The University of ManchesterHope HospitalStott LaneSalfordManchester M6 8HDUK Key Laboratory of Chinese Internal Medicine Ministry of EducationBeijing University of Chinese Medicine Institute of Clinical Medicine China Academy of Chinese Medical Sciences

OBJECTIVE： To investigate the neuroprotective mechanism of combination extract of Renshen （Ponax Ginseng）, Yinyanghuo （Herba Epimedii Brevi-comus）, Yuanzhi （Radix Palygalae） and Jianghuang （Rhizoma Curcumae Longae）（GEPT） in treating AI- zheimer＇s disease on the target of glycogen syn- thase kinase 3β（GSK-3β）. METHODS： Three-month-old APPV7171 transgenic mice were randomly divided into ten groups （n=12 per group） and intragastrically administrated vehi- cle or medicines： APP group was given 0.5% CMC, donepezil group was given donepezil （APP ＋ D group）（0.92 mg/kg-1. day-1）, and GEPT groups were given small dose of GEPT （APP＋Gs group）（0.075 g/ kg-1. day-1）, medium dose （APP＋Gm group）（0.15 g/ kg-1. day-1）, and large dose （APP＋GI group）（0.30 g/ kg-1. day-1） for 4 or 8 months, respectively. Three-month-old C57BL/6J mice as vehicle controls （n=12） were given 0.5% CMC for 4 or 8 months as well. The GSK-3β expression in the cortex of 7- and 11-month-old APPV7171 transgenic mice with and without GEPT or donepezil treatment and normal C57BL/6J mice were measured via Western blotting and Immunohistochemistry. RESULTS： Immunohistochemistry analysis showed significant increase of GSK-3β in the cerebral cortex of 7-month-old APP group （compare to control group P=0.003）, while the GSK-313 expression of donepezil or OEPT group were all significantly de-creased （Donepezil vs APP： P=0.041; GI vs APP： P=0.049, Gm vs APP： P=0.029, Gh vs APP： P=0.036）. Western blot analysis showed similar results. The densitometric measures of GSK-3β in APP mice in- creased significantly as compared with the control group （P=0.008）. And the GSK-3β expression indonepezil and GEPT groups were all decreased. There was significant difference between Gh group or donepezil group and the control group （P=0.05）. Similar findings were shown in the 11-month-old mice in each group, except for greater decrease of GSK-3β in the GEPT group. CONCLUSION： GEPT can effectively decrease the level of GSK-3β expression

关键词： Alzheimer disease Mice, transgenic Glycogen synthase kinase 3 traditional chinesemedicine Chinese medical formula

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Understanding health literacy from a traditional Chinese medicine perspective

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Journal of Integrative Medicine 2023年第3期21卷 215-220页

作者： Zhiyi Qian Grace Y.Wang Marcus Henning Yan Chen Centre for Medical and Health Science Education University of AucklandAuckland 1010New Zealand School of Psychology and Wellbeing University of Southern QueenslandToowoombaQueensland 4350Australia

Health literacy is critical to improving individual and public ***,indigenous perceptions of health are largely absent from Western-derived measurements,contributing to disparities in health outcomes between indigenous and non-indigenous *** is the country with the world's largest population and only officially introduced the term"health literacy"in *** measures of health literacy in China are primarily based on Western-derived constructs,which have been shown to have poor comparability to the unique dual medical system in *** its significant importance to health management globally,understanding health perceptions from a traditional Chinese medicine perspective is *** review explores the concept and core elements of indigenous health literacy,evaluates the existing definitions and measurement tools as applied to the concept,and proposes a new model of traditional Chinese medicine health literacy.

关键词： traditional chinesemedicine Health literacy Conceptual model Measurement

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Simultaneous quantification of five major active components in capsules of the traditional Chinese medicine 'Shu-Jin-Zhi-Tong' by high performance liquid chromatography

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Journal of Pharmaceutical Analysis 2011年第4期1卷 284-290页

作者： Xing-Xin Yang Xiao-Xia Zhang Rui-Miao Chang Yan.Wei Wang Xiao-Ni Li College of Pharmacy Shanxi Medical University 56 Xinjian South Road Taiyuan 030001 China

A simple and reliable high performance liquid chromatography （HPLC） method has been developed for the simultaneous quantification of five major bioactive components in ＇Shu-Jin- Zhi-Tong＇ capsules （SJZTC）, for the purposes of quality control of this commonly prescribed traditional Chinese medicine. Under the optimum conditions, excellent separation was achieved, and the assay was fully validated in terms of linearity, precision, repeatability, stability and accuracy. The validated method was applied successfully to the determination of the five compounds in SJZTC samples from different production batches. The HPLC method can be used as a valid analytical method to evaluate the intrinsic quality of SJZTC.

关键词： High performance liquidchromatography Quality control 'Shu-Jin-Zhi-Tong'capsules traditional chinesemedicine

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Chlorogenic acid ameliorates heart failure by attenuating cardiomyocyte ferroptosis

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Journal of traditional Chinese Medical Sciences 2024年第2期11卷 191-198页

作者： Kai Huang Fanghe Li Jiayang Tang Haiyin Pu Vasily Sukhorukov Alexander N.Orekhov Shuzhen Guo School of traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Laboratory of Angiopathology Institute of General Pathology and PathophysiologyRussian Academy of Medical SciencesMoscow125315Russia

Objective:To elucidate the effects of chlorogenic acid(CGA),a bioactive polyphenol compound prevalent in traditional Chinese medicine and various foods,including Lonicera japonica Thunb.(Jin Yin Hua),Eucommia ulmoides Oliv.(Du Zhong Ye),tea,and coffee,on cardiomyocyte ferroptosis and heart ***: We assessed the effect of CGA on cardiac function using a mouse model of heart failure induced by transverse aortic constriction(TAC).These indicators included the left ventricular ejection fraction(LVEF),fractional shortening(LVFS),end-systolic volume(LVESV),end-diastolic volume(LVEDV),end-systolic diameter(LVESD),and end-diastolic diameter(LVEDD).An isoprenaline hydrochloride(ISO)-induced H9c2 cardiomyocyte cell model was also established,and the cells were treated with various concentrations of *** assess the effect of CGA on ferroptosis in cardiomyocytes,we measured cell viability and evaluated the levels of intracellular reactive oxygen species(ROS),ferrous ions(Fe^(2+)),and lipid peroxidation using fluorescent *** clarify the ferroptosis signaling pathway regulated by CGA,western blotting was used to examine the expression of ferroptosis biomarkers,specifically solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4),in H9c2 cardiomyocytes and mouse myocardial ***: CGA significantly enhanced cardiac performance indices such as LVEF,LVFS,LVESV,LVEDV,LVESD,and LVEDD.H9c2 cardiomyocytes exposed to ISO showed decreased cell viability and increased ROS levels,Fe^(2+)content,and lipid peroxidation ***,CGA treatment significantly ameliorated these ***,in both H9c2 cardiomyocytes and myocardial tissue obtained from mice with TAC,CGA increased the expression of ferroptosis-related proteins,including SLC7A11 and ***: CGA has the potential to enhance cardiac function and diminish lipid peroxidation and ROS levels in cardiomyocytes via the SLC7A11/GPX4 signaling *** process allev

关键词： Chlorogenic acid Heart failure Ferroptosis H9c2 cardiomyocyte traditional chinesemedicine

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Analysis on patents of health care products with substances of medicine food homology in China

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Chinese Herbal Medicines 2024年第3期16卷 412-421页

作者： Haibo Liu Yanfeng Wang Jiali Huang Zhengqi Dong Peigen Xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Key Laboratory of traditional Chinese Medicine Patent Information Resources State Administration of Traditional Chinese MedicineBeijing 100080China Beijing Academy of Science and Technology Beijing 100048China

Objective:The concept of substances of medicine food homology(SMFH)has garnered significant attention in recent *** study conducts a systematic analysis of patent literature related to SMFH,and elucidates the development trends,technical hotspots,and the overall patent protection landscape of SMFH in China over the past two ***:The patent search focused on the SMFH varieties as the objects of inquiry,with retrieval conducted in patent ***,the acquired data underwent processing,analysis,and ***:While the technical threshold for pharmaceutical applications surpasses that of the food service sector,the former may assume a prominent role in the *** and development(R&D)activities in the southeast of China demonstrate robust activity than other *** and scientific research institutions exhibit substantial advantages in patent applications compared with individuals and hold greater potential for future ***:The findings of this patent analysis indicate that China’s SMFH industry are presently undergoing a transition from an extensive model to a high-quality *** quality and technical standards of SMFH products are consistently ***,there is a need for more stringent patent application requirements to align with the evolving development needs.

关键词： patent analysis patent pattern substances of medicine food homology traditional chinesemedicine

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traditional Chinese medicine diagnosis and treatment based on systematics

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iLIVER 2023年第4期2卷 181-187页

作者： Zhanhong Wang Danli Wang Wen Liu Zhongxia Wang The State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Beijing Hospital of traditional Chinese Medicine Capital Medical UniversityBeijing 100010China Department of Nutrition Fifth Medical CenterPLA General HospitalBeijing 100039China

Background:traditional Chinese Medicine(TCM)is a well-established medical system with a long ***,the overall concept and systematic thinking in TCM are not comprehensively understood and applied in its inheritance and *** This study aims to provide a basic theory for TCM diagnosis using systematics as the guiding *** modern scientific and technological achievements,we aim to explore a new TCM diagnosis ***:We analyzed previous studies on TCM diagnosis and treatment,and reviewed clinical research on TCM diagnosis and treatment from the viewpoint of *** propose a new process model based on systematics for TCM diagnosis and *** is a generalized model that summarizes the process of“establishing an image to express meaning”.Results:The proposed model was implemented in the clinical practice of *** monitored the detailed treatment process of patients in the Department of Liver Diseases at Beijing *** patient underwent a treatment program that lasted 1 year and 45 days,consisting of 12 iterative cycles,each guided by the proposed diagnostic model and tailored to the patient's evolving *** case study validates the effectiveness of the proposed model in the diagnosis and treatment of liver disease in *** therapeutic efficacy has been validated through the examination of both TCM indicators and Western medical auxiliary *** these,the TCM indicators consist of 2 components:tongue diagnosis and pulse ***,the Western medical auxiliary indicators encompass a range of assessments,including whole blood cell analysis,professional liver function examination,a series of liver function assessments,a high-sensitivity hepatitis B pentathlete test,as well as color Doppler ultrasound evaluations of the liver,bile duct,pancreas,spleen,and assessments of liver elasticity,among other related examination *** conclusion,it is evident that the syndrome of l

关键词： traditional chinesemedicine Systematics Diagnosis and treatment model Liver disease

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