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Anterior cingulate cortex substitutes for the impaired retrieval role of prelimbic cortex in trace eyeblink conditioning

Anterior cingulate cortex substitutes for the impaired retri...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Guang-Yan WU~(1,2,3),Zheng-Li FAN~2,Xuan LI~2,Bing WU~2,Rui FAN~4,Jian-Feng SUI~(1,2,*) 1 Department of Physiology,College of Basic Medical Sciences,Third Military Medical University,Chongqing 400038, China 2 Experimental Center of Basic Medicine,College of Basic Medical Sciences,Third Military Medical University, Chongqing 400038,China 3 The Second Team of Cadet Brigade,Third Military Medical University,Chongqing 400038,China 4 Department of Rehabilitation,the Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010, China

＜正＞Objective It has been suggested that the anterior cingulate cortex（ACC） and prelimbic cortex（PL） of medial prefrontal cortex（mPFC） have critical roles in the acquisition and retrieval（expression） processes of trace eyeblink conditioning（TEC）,*** was also reported that re-training after PL lesions following initial learning could recover the impaired behavioral *** on these results,we hypothesized that ACC substituted for the impaired retrieval role of PL in *** present study is to investigate（1） the hypothesis of TEC retrieval substitution and（2） the natural roles of ACC and PL in *** Lidocaine hydrochloride（LH） or saline was microinfused into ACC,or PL,or both ACC and PL after daily pre-infusion session training following 8 days initial acquisition ***（1） Infusion of lidocaine into area 24 does not significantly affect TEC expression.（2） Area 24 infusions affect TEC acquisition as evidenced by a difference in pre-infusion and post-infusion performance between sham and lesion groups that develops over several infusion days.（3） Area 32 infusions have immediate effect on TEC expression.（4） The expression deficits with area 32 infusions fades over 5 infusion sessions,and（5） subsequent dual infusions into both regions produces immediate deficits that do not *** The results support our hypothesis of substitution and also indicate that reversible inactivation of ACC prevented the acquisition of TEC but did not affect its retrieval,whereas reversible inactivation of PL caused significant deficits in retrieval of TEC,but did not affect its acquisition.

关键词： guinea pig lidocaine hydrochloride medial prefrontal cortex retrieval substitution reversible inactivation trace conditioning

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Prefrontal control of cerebellum-dependent motor learning

Prefrontal control of cerebellum-dependent motor learning

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中国神经科学学会第十届全国学术会议

作者： Hao CHEN Li YANG Jian-Feng SUI Bo HU Department of Physiology College of Basic Medical SciencesThird Military Medical University

Objective Every leaning act entails the participation of multiple brain *** lines of evidence have demonstrated that both the medial prefrontal cortex(mPFC) and cerebellum play essential roles in trace eyebhnk conditioning,a tractable behavioral model of associative motor ***,information regarding the mechanism(s) by which the two brain regions interact is *** present study is undertaken to determine whether the mPFC controls cerebellum-dependent motor learning through its persistent outputs and to examine how the persistent outputs are engaged in differential paradigms of eyeblink *** Electrical microstimulation of the caudal mPFC served as a conditioned stimulus(CS).The brain areas were reversibly inactivated by a selective GABA receptor agonist *** It was found that persistent outputs from the caudal mPFC to cerebellum were necessary for the acquisition and expression of an associative and learned CR-like responses,whose behavioral features are similar to those of normal trace CR generated by a tone ***,the persistent outputs of caudal mPFC were relayed to the cerebellum via rostral,rather than caudal part of the pontine ***,interfering with persistent activities by blockade of the muscarinic Ach receptors in the caudal mPFC impaired the expression of learned trace *** These results suggest an important functional way for the caudal mPFC to interact with the cerebellum during associative motor learning.

关键词： trace conditioning eyeblink prefrontal cortex persistent activity cerebellum pontine nucleus

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