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MRI-Based Patient-Specific Left Ventricular Model to Determine the Effects of trabeculae Carneae on the Diastolic and Systolic Functions

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医用生物力学 2019年第A1期34卷 19-20页

作者： Fatemeh Fatemifar Marc Feldman Geoffrey Clarke Ender Finol Haichao Han Department of Mechanical Engineering and Biomedical Engineering Graduate Program University of Texas at San AntonioSan AntonioTX78249USA Department of Medicine 3.Research Imaging InstituteUniversity of Texas HealthScience Center at San AntonioTX78229USA

Introduction trabeculae carneae are irregular structures that cover the endocardial surfaces of both ventricles of human heart and account for a significant portion of the ventricular ***,the role of trabeculae carneae in left ventricular(LV)function is not well *** reports suggested that trabeculae help squeeze blood from the apical region during systole[1].Our recent study suggests that trabeculae carneae hypertrophy and fibrosis contribute to increased LV stiffness in patients with diastolic heart failure,and severing free-running trabeculae carneae may improve diastolic compliance of the LV[2].Objective To understand the role of trabeculae carneae in the left ventricular diastolic and systolic functions using anatomically detailed patient-specific finite element models of the human ***(1)Image acquisition An explanted human heart was collected from a 63 year old female donor with a history of stroke and congestive heart failure within 24 hours postmortem from South Texas Blood and Tissue Center(San Antonio,TX).The heart was de-identified in accordance with Institutional Review Board(IRB)requirements and informed consent for research was obtained from the donor’s ***-dimensional MRI scanning was conducted on a 3T(128 MHz)MRI system(TIM Trio,Siemens Medical Solutions),comprised of a superconducting magnet with a 60 cm diameter accessible bore,when the heart was submerged in a saline filled plastic container.(2)Finite element analysis Three distinct LV models were derived from the MR *** first model was the intact trabeculated model(TM)which contained all trabeculae carneae and papillary *** high-resolution anatomically detailed 3D model of the LV was segmented from 2D MR images in DICOM format using Mimics(Materialise NV,Leuven,Belgium).The second model was the papillary model(PM),in which the papillary muscles remain intact but most of the trabeculae carneae were excluded in the smoothing *** third

关键词： EF MRI-Based Patient-Specific trabeculae Carneae the Diastolic and Systolic F Model

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Regional Variations in Trabecular Morphological Features of Femoral Head of Patients with Proximal Femoral Fractures

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Journal of Bionic Engineering 2015年第2期12卷 294-303页

作者： Linwei Lv Guangwei Meng He Gong Dong Zhu Jiazi Gao Meisheng Zhao School of Mechanical Science and Engineering Jilin University Changchun 130022 China School of Mechanical Engineering Tianjin University of Technology Tianjin 300384 China Department of Orthopedic Surgery the First Clinical Hospital of Jilin University Changchun 130021 China Department of Cataract Eye Hospital of the Second Clinical Hospital of Jilin University Changchun 130000 China

The regional microstructural variations in femoral head from proximal femoral fracture patients were investigated. Mi- cro-CT scanning was performed on seven femoral heads from proximal femoral fracture patients. Each femoral head was divided into three regions according to the trabecular orientation from the fovea of femoral head to the femoral neck. Eight three-dimensional trabecular cube models were reconstructed from each region. A total of 154 trabecular cubic models were reconstructed because the corresponding areas for 14 cubic models were damaged during the surgeries. Eight trabecular mor- phological parameters were measured and analyzed, namely, trabecular thickness （***）, trabecular separation （***）, spe- cific bone surface （BS/BV）, bone volum在不 fraction （BV/TV）, structural model index （SMI）, degree of anisotropy （DA）, trabecular pattern factor （***）, and trabecular number （Tb.N）. Bivariate correlation analyses were performed for all mor- phological parameters. One-way ANOVA tests were performed to analyze the differences of each parameter among three re- gions. Post-hoc multiple comparisons （Student-Newman-Keuls method） were performed to analyze the morphological differ- ence between two regions. Trabecular bone of proximal femoral fracture patients significantly degenerated in all regions of femoral heads. BV/TV was statistically correlated with ***, ***, BS/BV, ***, and Tb.N （p 〈 0.05）. Statistical differences in morphological parameters were observed between regions （p 〈 0.05）. The trabecular strength in the middle regions was significantly higher than that in other regions because of the relationships between morphological parameters and mechanical parameters. trabeculae in the medial region were more uniform and stable along each direction than those in the lateral region. Most trabeculae in the lateral region only grew along the weight-bearing direction, and those along the other directions de- generated significantly. This study provide

关键词： femoral head trabeculae proximal femur fracture morphological parameter micro-CT

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Influence Mechanism of the Trabecular and Chamfer Radii on the Three-point Bending Properties of Trabecular Beetle Elytron Plates

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Journal of Bionic Engineering 2021年第2期18卷 409-418页

作者： Xiaoming Zhang Xindi Yu Jinxiang Chen Caiqi Zhao Sujun Guan Yaqin Fu School of Civil Engineering Southeast UniversityNanjing 211189China Department of Physics Tokyo University of ScienceTokyo 1628601Japan College of Materials and Textiles Zhejiang Sci-Tech UniversityHangzhou 310018China

To improve the mechanical properties of Trabecular Beetle Elytron Plates(TBEPs,a type of biomimetic sandwich structure inspired by the beetle elytron)under transverse loads,three-point bending tests are performed to investigate the influence of the trabecular and chamfer radii of the core structure on the mechanical performance of TBEPs manufactured by 3D printing *** results show that the three-point bending performance of TBEPs can be improved by setting reasonable trabecular and chamfer radii;however,excessive increases in these radii can cause a decline in the mechanical *** the reason,these two structural parameters can enhance the deformation stiffness of the whole structure and the connection property between the core and skin,which is also the mechanical reason why Prosopocoilus inclinatus beetle elytra have thick,short trabeculae with a large chamfer ***,when these radii increase to a certain extent,the cracks are ultimately controlled between two adjacent trabeculae,and the failure of the plate is determined by the skin rather than the core ***,this study suggests a reasonable range for trabecular and chamfer radii,and indicates that TBEPs are better suited for engineering applications that have high compression requirements and general bending requirements.

关键词： beetle elytron bio-inspired structure sandwich structure honeycomb plate trabeculae bending properties

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Left ventricular non-compaction presenting as cardio-embolic stroke

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Journal of Geriatric Cardiology 2020年第10期17卷 645-646页

作者： Andres Martinez Michael Omar Fadi Kandah Jose Ruiz Ahsan Niazi Department of Internal Medicine University of Florida College of Medicine-JacksonvilleFloridaUSA Department of Cardiology University of Florida College of Medicine-JacksonvilleFloridaUSA Department of Neurology University of Florida College of Medicine-JacksonvilleFloridaUSA

A 39-year-old male with no known comorbidities presented with sudden onset right-sided *** examination,blood pressure was 128/79 mmHg,National Institutes of Health Stroke Scale score was 4 and there were no signs of heart *** computerized tomography demonstrated an ischemic infarct of the left middle cerebral artery distribution and brain magnetic resonance imaging later confirmed it(Figure 1).

关键词： Cardio-embolic Cardiomyopathy Non-compaction trabeculae

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