检索结果-南通市图书馆

UV/H2O2 oxidation of tri(2-chloroethyl) phosphate: Intermediate products, degradation pathway and toxicity evaluation

引用

Journal of Environmental Sciences 2020年第12期32卷 55-61页

作者： Qiuyi Ji Huan He Zhanqi Gao Xiaohan Wang Shaogui Yang Cheng Sun Shiyin Li Yong Wang Limin Zhang School of Environment Nanjing Normal UniversityNanjing 210023China State Environmental Protection Key Laboratory of Monitoring and Analysis for Organic Pollutants in Surface Water Environment Monitoring Center of JiangsuNanjing 210036China State Key Laboratory of Pollution Control and Resources Reuse School of EnvironmentNanjing UniversityNanjing 210023China School of Environment Northeast Normal UniversityChangchun 130024China

Tri(2-chloroethyl) phosphate(TCEP) with the initial concentration of 5 mg/L was degraded by UV/H2O2 oxidation process. The removal rate of TCEP in the UV/H2O2 system was 89.1% with the production of Cl-and PO4^3- of 0.23 and 0.64 mg/L. The removal rate of total organic carbon of the reaction was 48.8% and the pH reached 3.3 after the reaction. The oxidative degradation process of TCEP in the UV/H2O2 system obeyed the first order kinetic reaction with the apparent rate constant of 0.0025 min^-1( R^2 = 0.9788). The intermediate products were isolated and identified by gas chromatography-mass spectrometer. The addition reaction of HO · and H2O and the oxidation reaction with H2O2 were found during the degradation pathway of 5 mg/L TCEP in the UV/H2O2 system. For the first time, environment risk was estimated via the "ecological structure activity relationships" program and acute and chronic toxicity changes of intermediate products were pointed out. The luminescence inhibition rate of photobacterium was used to evaluate the acute toxicity of intermediate products. The results showed that the toxicity of the intermediate products increased with the increase of reaction time, which may be due to the production of chlorine compounds. Some measures should be introduced to the UV/H2O2 system to remove the highly toxic Cl-containing compounds, such as a nanofiltration or reverse osmosis unit.

关键词： Tri(2-chloroethyl)phosphate(TCEP) UV/H2O2 Mechanisms toxicity evaluation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

toxicity evaluation of collagen hydrolysates from chrome shavings and their potential use in the preparation of amino acid fertilizer for crop growth

引用

Journal of Leather Science and Engineering 2022年第1期4卷 14-36页

作者： Li Zhao Shengdong Mu Weixiang Wang Haibin Gu Key Laboratory of Leather Chemistry and Engineering of Ministry of Education Sichuan UniversityChengdu 610065China National Engineering Research Center of Clean Technology in Leather Industry Sichuan UniversityChengdu 610065China College of Food and Bioengineering Xihua UniversityChengdu 610039China.

Resource utilization of chrome shavings(CS)has attracted a lot of attention from scientists and technologists in leather industry.Especially,the collagen hydrolysates extracted from CS are expected to find potential application values in agricultural field.However,there is no biotoxicity analysis of collagen hydrolysates from CS.Herein,the collagen hydrolysates with different molecular weights were produced from CS by three hydrolysis dechroming methods including alkaline hydrolysis,enzymatic hydrolysis and alkaline-enzymatic synergistic hydrolysis,and the optimal hydrolysis process of CS was designed and conducted.To evaluate their toxicity,the three collagen hydrolysates were formulated into a nutrient solution for zebrafish development.The obtained results indicated that the hydrolysates with low concentrations(less than 0.6 mg/mL)were safe and could promote the development for zebrafish embryos.Furthermore,the three collagen hydrolysates were utilized as organic nitrogen sources and formulated into amino acid water-soluble fertilizers(AAWSF)including alkaline type fertilizer(OH),enzymatic type fertilizer(M)and alkaline-enzymatic type fertilizer(OH-M)for the early soilless seeding cultivation of wheat,soybean and rapeseed.It is worth mentioning that the chromium contents in the prepared AAWSF were less than 10 mg/kg,which is far less than the limit value in the standard(China,50 mg/kg).The growth and development of seedlings(germination rate,plant height,fresh weight of leaves,soluble sugar content and chlorophyll content)were investigated.The corresponding results showed that the growth of seedlings watered with AAWSF was better compared with the other treatments,and the OH-M fertilizer had the best promoting effect on the seedlings growth and development,followed by the M and OH fertilizers.The safe toxicity assessment of the collagen hydrolysates will expand their application scope,and the use of collagen hydrolysates extracted from CS for seedlings growth also provides an effective and reason-able way to d

关键词： Chrome shavings Collagen hydrolysate Zebrafish toxicity evaluation Amino acid water-soluble fertilizer Seedling growth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The toxicity evaluation of Recombinant Replicating Vaccinia Virus Vaccine in BALB/c Mice

The Toxicity Evaluation of Recombinant Replicating Vaccinia ...

引用

第十三届中国科协年会第5分会场-化学物的环境危害与健康...

作者： Sanlong WANG 1 , Limei CAO 1 , Yin LIU 2 , Danli DUAN 2 , Xiuwen WANG 1 , Bo LI 1 , Yiming SHAO 2 (1. National Center for Safety evaluation of Drugs, National Institute for the Control of Pharmaceutical & Biological Products, Tianjin 300050, China 2. National Center for AIDS/STD Prevention and Control, China CDC, Beijing 100050, China)

To evaluate the preclinical safety of recombinant replicating vaccinia virus-based HIV vaccines （rVVV）in BALB/c mice. The study was composed of groups 1, 2, 3, 4, wherein the groups 1 and 2 received only one priming immunization and the groups 3, 4 received prime-boost immunizations at a 6-week interval. The dose given was 50μl/skin of back/2 dosing point by intradermal injection approximately 2.2×10 6 PFU. Cellular responses were evaluated in spleenocytes after restimulation on the following basis: detection of IFN-γ producing CD8 + -positive T cells, and CD4 + /CD8 + T cells ratio by FACS assay. Humoral responses were evaluated in serum samples on the basis of specific anti-rVVV antibodies. A real-time quantitative PCR was employed for detection of biodistribution of rVVV in tissues and organs. The results showed that there were no significant toxic effects and damages to major organs in control and rVVV-treated animals. The results of FACS analysis assay for the group 4 that received prime-boost immunization showed cellular immune responses, as indicated by high IFN-γ production by CD8 + -positive T cells. There was no significant change for the CD4 + /CD8 + T cells ratio in control and rVVV-treated animals. Immunogenicity of rVVV given with prime-boost doses was stronger than that of rVVV given with a single priming dose in BALB/c mice. Following intradermal injection of rVVV in mice, all tissues were Q-PCR-negative on Day 35 after dosing. The study showed that there were no significant toxic effects and the rVVV could induce both humoral and cellular immune responses in BALB/c mice.

关键词： toxicity evaluation Recombinant replicating vaccinia virus Vaccine BALB/c Mice

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging

引用

Nano Research 2017年第4期10卷 1234-1248页

作者： Mei Chen Shuzhen Chen Chengyong He Shiguang Mo Xiaoyong Wang Gang Liu Nanfeng Zheng State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Engineering Research Center for Nano-Preparation Technology of Fujian Province College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361005 China Department of Microbiology and Immunology Xiamen Medical College Xiamen 361008 China

Two-dimensional （2D） nanosheets have emerged as an important class of nanomaterial with great potential in the field of biomedicines, particularly in cancer theranostics. However, owing to the lack of effective methods that synthesize uniform 2D nanomaterials with controlled size, systematic evaluation of size-dependent bio-behaviors of 2D nanomaterials is rarely reported. To the best of our knowledge, we are the first to report a systematic evaluation of the influence of size of 2D nanomaterials on their bio-behaviors. 2D Pd nanosheets with diameters ranging from 5 to 80 nm were synthesized and tested in cell and animal models to assess their size-dependent bioapplication, biodistribution, elimination, toxicity, and genomic gene expression profiles. Our results showed size significantly influences the biological behaviors of Pd nanosheets, including their photothermal and photoacoustic effects, pharmacokinetics, and toxicity. Compared to larger-sized Pd nanosheets, smaller-sized Pd nanosheets exhibited more advanced photoacoustic imaging and photothermal effects upon ultralow laser irradiation. Moreover, in vivo results indicated that 5-nm Pd nanosheets escape from the reticuloendothelial system with a longer blood half-life and can be cleared by renal excretion, while Pd nanosheets with larger sizes mainly accumulate in the liver and spleen. The 30-nm Pd nanosheets exhibited the highest tumor accumulation. Although Pd nanosheets did not cause any appreciable toxicity at the cellular level, we observed slight lipid accumulation in the liver and inflammation in the spleen. Genomic gene expression analysis showed that 80-nm Pd nanosheets interacted with more cellular components and affected more biological processes in the liver, as compared to 5-nm Pd nanosheets. We believe this work will provide valuable information and insights into the clinical application of 2D Pd nanosheets as nanomedicines.

关键词： Pd nanosheets photothermal therapy photoacoustic imaging toxicity evaluation genomic gene expression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

toxicity Assessment of Cyanide and Tetramethylene Disulfotetramine （Tetramine） Using Luminescent Bacteria Vibrio-qinghaiensis and PbO= Electrochemical Sensor

引用

Chinese Journal of Chemistry 2007年第2期25卷 203-207页

作者：刘炜蒋金刚施国跃何艳刘烨金利通 Department of Chemistry East China Normal University Shanghai 200062 China Department of Btology East China Normal University Shanghai 200062 China

The toxicities of cyanide and tetramethylene disulfotetramine （tetramine） were evaluated by two methods of luminescent bacteria and PbO2 electrochemical sensor. Vibrio-qinghaiensis, a kind of luminescent bacteria, can produce bioluminescence and the bioluminescence was decreased with the addition of toxicants. The toxicities of cyanide and tetrarnine were expressed as 10 min-EC50 value, which was the concentration of chemical that reduces the light output by 50% after contact for 10 min. Nano PbO2 modified electrode, a rapid toxicity determination method was also described in this work. By the PbO2 modified electrode, the current responses of Escherichia coli （E. coli） were changed with the addition of toxicants. The value of 10 min-EC50 was also provided with the PbO2 electrochemical sensor. Compared with the 10 min-EC50 and detection limits （38.38 and 0.60 μg/mL for cyanide, 0.24 and 0.02 μg/mL for tetramine） with luminescent bacteria, the PbO2 sensor provided a simple and convenient method with lower 10 min-EC50 and detection limits （26.37 and 0.52 μg/mL for cyanide, 0.21 and 0.01 μg/mL for tetramine） and fast response time.

关键词： toxicity evaluation bioluminescent bacteda PbO2 electrochemical sensor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：