检索结果-南通市图书馆

tobacco, air pollution, environmental carcinogenesis, and thoughts on conquering strategies of lung cancer

Cancer Biology & Medicine 2019年第4期16卷 700-713页

作者： Guangbiao Zhou State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Each year there will be an estimated 2.1 million new lung cancer cases and 1.8 million lung cancer deaths worldwide.tobacco smoke is the No.1 risk factors of lung cancer,accounting for>85%lung cancer deaths.Air pollution,or haze,comprises ambient air pollution and household air pollution,which are reported to cause 252,000 and 304,000 lung cancer deaths each year,respectively.tobacco smoke and haze(hereafter,smohaze)contain fine particles originated from insufficient combustion of biomass or coal,have quite similar carcinogens,and cause similar diseases.Smohaze exert hazardous effects on exposed populations,including induction of a large amount of mutations in the genome,alternative splicing of mRNAs,abnormalities in epigenomics,initiation of tumor-promoting chronic inflammation,and facilitating immune escape of transformed cells.Tackling smohaze and development of multi-targets-based preventive and therapeutic approaches targeting smohaze-induced carcinogenesis are the key to conquer lung cancer in the future.

关键词： Lung cancer tobacco smoke air pollution smohaze carcinogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells

引用

Frontiers of Medicine 2021年第2期15卷 252-263页

作者： Guizhen Wang Qun Zhao Hui Zhang Fan Liang Chen Zhang Jun Wang Zhenyin Chen Ran Wu Hong Yu Beibei Sun Hua Guo Ruie Feng Kaifeng Xu Guangbiao Zhou State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of Sciences&University of Chinese Academy of SciencesBeijing 100101China Hubei University of Medicine Shiyan 442000China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Pulmonary and Critical Care Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Guizhou University School of Medicine Guiyang 550025China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China

An unexpected observation among the COVID-19 pandemic is that smokers constituted only 1.4%–18.5%of hospitalized adults,calling for an urgent investigation to determine the role of smoking in SARS-CoV-2 infection.Here,we show that cigarette smoke extract(CSE)and carcinogen benzo(a)pyrene(BaP)increase ACE2 mRNA but trigger ACE2 protein catabolism.BaP induces an aryl hydrocarbon receptor(AhR)-dependent upregulation of the ubiquitin E3 ligase Skp2 for ACE2 ubiquitination.ACE2 in lung tissues of non-smokers is higher than in smokers,consistent with the findings that tobacco carcinogens downregulate ACE2 in mice.tobacco carcinogens inhibit SARS-CoV-2 spike protein pseudovirions infection of the cells.Given that tobacco smoke accounts for 8 million deaths including 2.1 million cancer deaths annually and Skp2 is an oncoprotein,tobacco use should not be recommended and cessation plan should be prepared for smokers in COVID-19 pandemic.

关键词： SARS-CoV-2 tobacco smoke benzo(a)pyrene ACE2 Skp2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of an E3 ligase-encoding gene RFWD3 in non-small cell lung cancer

引用

Frontiers of Medicine 2020年第3期14卷 318-326页

作者： Yanfei Zhang Xinchun Zhao Yongchun Zhou Min Wang Guangbiao Zhou State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China University of Chinese Academy of Sciences Beijing 100049China School of Life Sciences University of Science and Technology of ChinaHefei 230026China Department of Thoracic Surgery the Third Affiliated Hospital of Kunming Medical UniversityKunming 650106China

In order to unveil ubiquitin pathway genes (UPGs) that are essential for non-small cell lung cancer (NSCLC) cell proliferation,we recently conducted a siRNA screening experiment to knockdown the expression of 696 UPGs found in the human genome in A549 and H1975 NSCLC cells.We found that silencing of one of the candidates,RFWD3 that encodes an E3 ubiquitin ligase essential for the repair of DNA interstrand cross-links inresponse to DNA damage,led to dramatic inhibition of NSCLC cell proliferation with significant Z-scores.Knockdown of RFWD3 suppressed colony forming activity of NSCLC cells.We further evaluated the significance of RFWD3 in NSCLCs and found that this gene was more elevated in tumor samples than in paired normal lung tissues and was inversely associated with the clinical outcome of patients with NSCLC.Moreover,RFWD3 expression was significantly higher in smokers than in non-smokers.These results show for the first time that RFWD3 is required for NSCLC cell proliferation and may have an important role in lung carcinogenesis.

关键词： RFWD3 NSCLC prognosis tobacco smoke

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carcinogens that induce the A：T 〉 T：A nucleotide substitutions in the genome

引用

Frontiers of Medicine 2018年第2期12卷 236-238页

作者： Guangbiao Zhou Xinchun Zhao State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Bering 100101 China

Recently, Ng et al. reported that the A：T 〉 T：A substitutions, proposed to be a signature of aristolochic acid （AA） exposure, were detected in 76/98 （78%） of patients with hepatocellular carcinoma （HCC） from the Taiwan Province of China, and 47% to 1.7% of HCCs from the Chinese mainland and other countries harbored the nucleotide changes. However, other carcinogens, e.g., tobacco carcinogens 4-aminobiphenyl and 1,3-butadiene, air toxic vinyl chloride and its reactive metabolites chloroethylene oxide, melphalan and chlorambucil, also cause this signature in the genome. Since tobacco smoke is a worldwide public health threat and vinyl chloride distributes globally and is an air pollutant in Taiwan Province, the estimation of the patients＇ exposure history is the key to determine the ＂culprit＂ of the A：T 〉 T：A mutations. Apparently, without estimation of the patients＇ exposure history, the conclusion of Ng et al, is unpersuasive and misleading.

关键词： genomic signature carcinogen aristolochic acid tobacco smoke vinyl chloride hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ultrastructural changes in embryoic neuroepithelial cells caused by passive smoking in golden hamsters at different periods of pregnancy: A randomized controlled trial

引用

Neural Regeneration Research 2007年第2期2卷 82-86页

作者： Dong Wang Xiangmin Yu Heng Cai Department of Histology and Embryology Binzhou Medical College Yantai 264000 Shandong Province China Department of Histology and Embryology Qingdao University Qingdao 266000 Shandong Province China

BACKGROUND： tobacco smoke exposure is recognized as a health risk for pregnant women and it is increasingly evident that tobacco smoke affects the development of brain. Recently, associations between maternal smoking during pregnancy and subsequent mental health problems in offspring have been reported. OBJECTIVE： To observe the effect of passive smoking on the morphology of nerve tissues and the ultrastructure of neuroepithelial cells during embryogenesis in golden hamster at different pregnant period. DESIGN： A randomized control study. SETTING： Department of Histology and embryology, Qingdao University. MATERIALS： Adult golden hamsters, including 40 males and 40 females that had not delivered, weighing （105±5） g, were provided by Shenyang Changsheng Biotechnology, Co.,Ltd. At 20 ： 00 - 21 ： 00, one male and one female were matched in each cage, and their mating was observed. The vaginal swabs were examined the next day and the day of positive sperm was taken as embryonic day 1 （E1）. METHODS： The experiment was completed in the Department of Histology and Embryology of Qingdao University from September 2001 to September 2003. （1） Abnormality caused by smoking, grouping and model establishment： A total of 40 healthy pregnant golden hamsters were randomly divided into control group （n =20） and experimental group （n =20）. The hamsters in the experimental group were exposed to tobacco smoke from embryonic day 4 to 7, 3 times per day, continuously 1 hour per time, 1 cigarette per golden hamster, for 4 consecutive days in the self-made chamber. The animals in the control group were given the same conditions as those in the experimental group except exposure to smoke. （2） Observation with transmission electron microscope： According to different gestational ages, the experimental group and the control group were all divided 4 subgroups （Groups A, B, C and D） respectively, and 5 hamsters in each subgroup. The pregnant golden hamsters were anaesthetized with 1 g/L pentobarbital sodium at 12 ： 00 and 18 ： 00 at E8, 8 ： 00

关键词： tobacco smoke neural tube defects embryo development mesocricetusek

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：