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Customized bioceramic scaffolds and metal meshes for challenging large-size mandibular bone defect regeneration and repair

引用

Regenerative Biomaterials 2023年第1期10卷 1178-1191页

作者： Bin Zhang Xiaohong Yin Feng Zhang Yirong Hong Yuesheng Qiu Xianyan Yang Yifan Li Cheng Zhong Huayong Yang Zhongru Gou State Key Laboratory of Fluid Power&Mechatronic Systems Zhejiang UniversityHangzhou 310058China School of Mechanical Engineering Zhejiang UniversityHangzhou 310058China Department of Stomatology Children’s HospitalZhejiang University School of MedicineHangzhou 310003China Bio-Nanomaterials and Regenerative Medicine Research Division Zhejiang-California International Nanosystem InstituteZhejiang UniversityHangzhou 310058China Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Large-size mandible graft has huge needs in clinic caused by infection,tumor,congenital deformity,bone trauma and so ***,the reconstruction of large-size mandible defect is challenged due to its complex anatomical structure and large-range bone *** design and fabrication of porous implants with large segments and specific shapes matching the native mandible remain a considerable ***,the 6%Mg-doped calcium silicate(CSi-Mg6)andβ-andα-tricalcium phosphate(β-TCP,α-TCP)bioceramics were fabricated by digital light processing as the porous scaffolds of over 50%in porosity,while the titanium mesh was fabricated by selective laser *** mechanical tests showed that the initial flexible/compressive resistance of CSi-Mg6 scaffolds was markedly higher than that ofβ-TCP andα-TCP *** experiments showed that these materials all had good biocompatibility,while CSi-Mg6 significantly promoted cell *** the rabbit critically sized mandible bone defects(∼13 mm in length)filled with porous bioceramic scaffolds,the titanium meshes and titanium nails were acted as fixation and load *** results showed that the defects were kept during the observation period in the blank(control)group;in contrast,the osteogenic capability was significantly enhanced in the CSi-Mg6 andα-TCP groups in comparison with theβ-TCP group,and these two groups not only had significantly increased new bone formation but also had thicker trabecular and smaller trabecular ***,the CSi-Mg6 andα-TCP groups showed appreciable material biodegradation in the later stage(from 8 to 12 weeks)in comparison with theβ-TCP scaffolds while the CSi-Mg6 group showed much outstanding mechanical capacity in vivo in the early stage compared to theβ-TCP andα-TCP ***,these findings suggest that the combination of customized strength-strong bioactive CSi-Mg6 scaffolds together with titanium meshes is a promising way for repairing the large-size load-bearing

关键词： customized design bioceramic scaffolds titanium meshes mandibular bone reconstruction additive manufacturing

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