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metalloproteinases as mediators of inflammation and the eyes： molecular genetic underpinnings governing ocular pathophysiology

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1308-1318页

作者： Mahavir Singh Suresh C Tyagi Eye and Vision Science Laboratory Department of Physiology University of Louisville School of Medicine Louisville KY 40202 USA

There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases （MMPs）; the Zn （2＋）-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degeneration, diabetic retinopathy, and glaucoma via understanding MMPs regulation in affected patients, interactions of MMPs with their substrate molecules, and key regulatory functions of tissue inhibitor of metalloproteinases （TIMPs） towards maintaining overall homeostasis.

关键词： age-related macular degeneration choroidal neovascularization diabetes glaucoma metalloproteinases tissue inhibitors of metalloproteinases

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Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 973-981页

作者： Qing-Yang Feng Zi-Xuan Hu Xi-Ling Song Hong-Wei Pan Department of Ophthalmology the First Affiliated Hospital of Jinan University Department of Public Health and Preventive Medicine Jinan University Institute of Ophthalmology School of MedicineJinan University

Pterygium is a common ocular surface disease induced by a variety of factors. The exact pathogenesis of pterygium remains unclear. Numbers of genes and proteins are discovered in pterygium and they function differently in the occurrence and development of this disease. We searched the Web of Science and PubMed throughout history for literatures about the subject. The keywords we used contain pterygium, gene, protein, angiogenesis, fibrosis, proliferation, inflammation, pathogenesis and therapy. In this review, we summarize the aberrant expression of a range of genes and proteins in pterygium compared with normal conjunctiva or cornea, including growth factors, matrix metalloproteinases and tissue inhibitors of mefalloproteinases, interleukins, tumor suppressor genes, proliferation related proteins, apoptosis related proteins, cell adhesion molecules, extracellular matrix proteins, heat shock proteins and tight junction proteins. We illustrate their possible mechanisms in the pathogenesis of pterygium as well as the related intervention based on them for pterygium therapy.

关键词： pterygium growth factors matrixmetalloproteinases tissue inhibitors of metalloproteinases interleukins tumor suppressor genes proliferation andapoptosis cell adhesion molecules extmcellular matrix proteins

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Complex role of matrix metalloproteinases in angiogenesis

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Cell Research 1998年第3期8卷 171-177页

作者： SANG QING XIANG AMY(Biochemistry Division, Department of Chemistry, Florida State University, Tallahassee, Florida 32306-4390, USA) Biochemistry Division Department of Chemistry Florida State University Tallahassee USA

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP) play a significant role in regulating angiogenesis, the process of new blood vessel formation. Interstitial collagenase (MMP-1), 72 kDa gelatinase A/type IV collagenase (MMP-2), and 92 kDa gelatinase B/type IV collagenase (MMP-9) dissolve extracellular matrix (ECM) and may initiate and Promote angiogenesis. TIMP-1, TIMP-2, TIMP-3, and possibly,TIMP-4 inhibit neovascularisation. A new paradigm is emerging that matrilysin (MMP-7), MMP-9, and metalloelastase (MMP-12) may block angiogehesis by converting plasndnogen to angiostatin, which is one of the most potent angiogenesis antagonists. MMPs and TIMPs play a complex role in regulating angiogenesis. An understanding of the biochemical and cellular pathways and mechanisms of angiogenesis will provide importal information to allow the control of angiogenesis, e.g. the stimulation of angiogenesis for coronary collateral circulation formation; while the inhibition for treating arthritis and cancer.

关键词： Collagenases tissue inhibitors of metalloproteinases neovascularization plasminogen angiostatin converting enzymes extracellular matrix

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