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Imaging and ex-vivo tissue analysis by Infrared CO2 Laser Assisted Rapid Evaporative Ionisation MS – towards an integrated MS-based tissue identification system

Imaging and ex-vivo tissue analysis by Infrared CO2 Laser As...

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2018年中国质谱学术大会（CMSC2018）

作者： Haixing Wang Zoltan Takats Key Laboratory of Anesthesiology of Zhejiang Province Department of AnesthesiologyThe Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Imperial College

As a direct combination of surgical diathermy and MS analysis of the electrosurgical aerosol, rapid evaporative ionization mass spectrometry(REIMS) is a novel ambient ionization method. Surgical REIMS(or iknife) has been demonstrated to provide real-time tissue identification during surgical interventions with a strong potential for margin control in oncological surgery and applied for food chemistry research already.[1-3] One of the remaining problems for the surgical REIMS is the construction of histologically annotated spectral databases, which are essential for pattern recognition-driven identification. Due to the destructive nature of the electrosurgical REIMS system, a tumor specimen gives limited data points and the histological identification of already evaporated cells is not straightforward. As an alternative, a infrared CO2 laser-based system was devised, which is capable of MS imaging and ex-vivo analysis of biological tissues. The setup is described, and optimization of the laser parameters is presented. REIMS analysis of the aerosol formed by laser ablation of tissue shows similar spectral characteristics to those acquired by the electrosurgery-REIMS system, with the data dominated by signals corresponding to complex lipids. Imaging of biological tissue with 100 μm resolution is demonstrated and the technique is then applied to human breast tissue samples. In contrast to the destructive nature of electrosurgical REIMS which limits the amount of data collected from a sample and makes histological identification challenging, laser REIMS imaging allows spectral data and histological information to be easily matched. Imaging data are collected for healthy and cancerous human breast tissue and are used to construct a histologically annotated spectral database, with excellent classification accuracy for real-time analysis.

关键词： rapid evaporative ionization mass spectrometry (REIMS) iknife MS imaging CO2 laser tissue identification

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