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Electrodeposition of chitosan/graphene oxide conduit to enhance peripheral nerve regeneration

Neural Regeneration Research 2023年第1期18卷 207-212页

作者： Ya-Nan Zhao Ping Wu Zi-Yuan Zhao Fei-Xiang Chen Ao Xiao Zhi-Yi Yue Xin-Wei Han Yong Zheng Yun Chen Department of Biomedical engineering and Hubei Province Key Laboratory of Allergy and Immune Related Disease School of Basic Medical SciencesWuhan UniversityWuhanHubei ProvinceChina Department of Interventional Radiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Clinical Medical College Hubei University of Science and TechnologyXianningHubei ProvinceChina

Currently available commercial nerve guidance conduits have been applied in the repair of peripheral nerve ***,a conduit exhibiting good biocompatibility remains to be *** this work,a series of chitosan/graphene oxide(GO)films with concentrations of GO varying from 0-1 wt%(collectively referred to as CHGF-n)were prepared by an electrodeposition *** effects of CHGF-n on proliferation and adhesion abilities of Schwann cells were *** results showed that Schwann cells exhibited elongated spindle shapes and upregulated expression of nerve regeneration-related factors such as Krox20(a key myelination factor),Zeb2(essential for Schwann cell differentiation,myelination,and nerve repair),and transforming growth factorβ(a cytokine with regenerative functions).In addition,a nerve guidance conduit with a GO content of 0.25%(CHGFC-0.25)was implanted to repair a 10-mm sciatic nerve defect in *** results indicated improvements in sciatic functional index,electrophysiology,and sciatic nerve and gastrocnemius muscle histology compared with the CHGFC-0 group,and similar outcomes to the autograft *** conclusion,we provide a candidate method for the repair of peripheral nerve defects using free-standing chitosan/GO nerve conduits produced by electrodeposition.

关键词： chitosan electrodeposition free-standing graphene oxide nerve conduit nerve factors Schwann cells tissue engineerin

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