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The liver tissue bank and clinical database in China

Frontiers of Medicine 2010年第4期4卷 443-447页

作者： Yuan YANG Yi-Min LIU Ming-Yue WEI Yi-Fei WU Jun-Hui GAO Lei LIU Wei-Ping ZHOU Hong-Yang WANG Meng-Chao WU Eastern Hepatobiliary Surgery Hospital Second Military Medical UniversityShanghai 200438China Shanghai Center for Bioinformation Technology Shanghai 200235China

To develop a standardized and well-rounded material available for hepatology research,the National Liver tissue bank(NLTB)Project began in 2008 in China to make well-characterized and optimally preserved liver tumor tissue and clinical *** Dec 2008 to Jun 2010,over 3000 individuals have been enrolled as liver tumor donors to the NLTB,including 2317 cases of newly diagnosed hepatocellular carcinoma(HCC)and about 1000 cases of diagnosed benign or malignant liver *** clinical database and sample store can be managed easily and correctly with the data management platform *** believe that the high-quality samples with detailed information database will become the cornerstone of hepatology research especially in studies exploring the diagnosis and new treatments for HCC and other liver diseases.

关键词： liver neoplasm tissue bank information systems standardization

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Hepatitis B transmission by cell and tissue allografts:How safe is safe enough?

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World Journal of Gastroenterology 2014年第23期20卷 7434-7441页

作者： Pilar Solves Vicente Mirabet Manuel Alvarez Blood bank Hospital Universitari I Politècnic La FeBulevar Sur46026 ValenciaSpain

More than 2 million human tissue transplants(bone,tendon,cartilage,skin,cornea,amniotic membrane,stem cells,heart valve,blood vessel,etc.),are performed worldwide every *** and tissues are shared between countries which have different regulations and laboratory equipment and represent a risk of hepatitis B virus(HBV)transmission that has become a global safety *** the risk of transfusiontransmitted HBV infection from blood donations has been estimated,the rate of HBV transmission from donors to recipients of allografts is unknown and varies between different *** are various important ways of reducing the transmission risk,but donor screening and donor testing are still the main factors for preventing HBV *** detection is included in the routine screening tests for cell and tissue *** standard test for preventing transplant-transmitted hepatitis B is the hepatitis B surface *** implementation of methods involving nucleic acid amplification and the new generation of reactives to detect viral antibodies or antigens with an immunoassay,has increased the sensitivity and the specificity of the screening *** objective of our research was to review the literature and critically analyse the different steps for avoiding HBV transmission in cell and tissue donors,focusing on the screening tests performed.

关键词： Hepatitis B virus tissue bank tissue transplantation

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