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Effects of targeted muscle reinnervation on spinal cord motor neurons in rats following tibial nerve transection

Neural Regeneration Research 2022年第8期17卷 1827-1832页

作者： Wei Lu Jian-Ping Li Zhen-Dong Jiang Lin Yang Xue-Zheng Liu Department of Human Anatomy School of Basic Medical ScinencesGuangxi Medical UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Human Anatomy Zhuhai Campus of Zunyi Medical UniversityZhuhaiGuangdong ProvinceChina

Targeted muscle reinnervation(TMR)is a surgical procedure used to transfer residual peripheral nerves from amputated limbs to targeted muscles,which allows the target muscles to become sources of motor control information for function reconstruction.However,the effect of TMR on injured motor neurons is still unclear.In this study,we aimed to explore the effect of hind limb TMR surgery on injured motor neurons in the spinal cord of rats after tibial nerve transection.We found that the reduction in hind limb motor function and atrophy in mice caused by tibial nerve transection improved after TMR.TMR enhanced nerve regeneration by increasing the number of axons and myelin sheath thickness in the tibial nerve,increasing the number of anterior horn motor neurons,and increasing the number of choline acetyltransferase-positive cells and immunofluorescence intensity of synaptophysin in rat spinal cord.Our findings suggest that TMR may enable the reconnection of residual nerve fibers to target muscles,thus restoring hind limb motor function on the injured side.

关键词： function reconstruction motor neuron nerve injury nerve implant Nissl staining spinal cord synaptophysin targeted muscle reinnervation tibial nerve transection

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Sensory reinnervation of muscle spindles after repair of tibial nerve defects using autogenous vein grafts

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Neural Regeneration Research 2014年第6期9卷 610-615页

作者： Youwang Pang Qingnan Hong Jinan Zheng Department of Orthopedics the 180 Hospital of Chinese PLA

Motor reinnervation after repair of tibial nerve defects using autologous vein grafts in rats has previously been reported, but sensory reinnervation after the same repair has not been fully investigated. In this study, partial sensory reinnervation of muscle spindles was observed after repair of lO-mm left tibial nerve defects using autologous vein grafts with end-to-end anasto- mosis in rats, and functional recovery was confirmed by electrophysiological studies. There were no significant differences in the number, size, or electrophysiological function of reinnervated muscle spindles between the two experimental groups. These findings suggest that repair of short nerve defects with autologous vein grafts provides comparable results to immediate end-to-end anastomosis in terms of sensory reinnervation of muscle spindles.

关键词： nerve regeneration peripheral nerve injury muscle spindle vein tibial nerve gastroc-nemius muscle nearofilament protein H neural regeneration

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The anatomical,electrophysiological and histological observations of muscle contraction units in rabbits:a new perspective on nerve injury and regeneration

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Neural Regeneration Research 2022年第1期17卷 228-232页

作者： Ting-Min Xu Bo Chen Zong-Xue Jin Xiao-Feng Yin Pei-Xun Zhang Bao-Guo Jiang Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Center Peking University People’s HospitalBeijingChina National Trauma Medical Center BeijingChina Department of Rehabilitation Peking University People’s HospitalBeijingChina

In the conventional view a muscle is composed of intermediate structures before its further division into microscopic muscle fibers.Our experiments in mice have confirmed this intermediate structure is composed of the lamella cluster formed by motor endplates,the innervating nerve branches and the corresponding muscle fibers,which can be viewed as an independent structural and functional unit.In this study,we verified the presence of these muscle construction units in rabbits.The results showed that the muscular branch of the femoral nerve sent out 4–6 nerve branches into the quadriceps and the tibial nerve sent out 4–7 nerve branches into the gastrocnemius.When each nerve branch of the femoral nerve was stimulated from the most lateral to the medial,the contraction of the lateral muscle,intermediate muscle and medial muscle of the quadriceps could be induced by electrically stimulating at least one nerve branch.When stimulating each nerve branch of the tibial nerve from the lateral to the medial,the muscle contraction of the lateral muscle 1,lateral muscle 2,lateral muscle 3 and medial muscle of the gastrocnemius could be induced by electrically stimulating at least one nerve branch.Electrical stimulation of each nerve branch resulted in different electromyographical waves recorded in different muscle subgroups.Hematoxylin-eosin staining showed most of the nerve branches around the neuromuscular junctions consisted of one individual neural tract,a few consisted of two or more neural tracts.The muscles of the lower limb in the rabbit can be subdivided into different muscle subgroups,each innervated by different nerve branches,thereby allowing much more complex muscle activities than traditionally stated.Together,the nerve branches and the innervated muscle subgroups can be viewed as an independent structural and functional unit.This study was approved by the Animal Ethics Committee of Peking University People’s Hospital(approval No.2019 PHE027)on October 20,2019.

关键词： anatomy electrophysiology femoral nerve hematoxylin-eosin staining gastrocnemius motor endplate muscle contraction unit peripheral nerve quadriceps rabbit skeletal muscle tibial nerve

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Serial Neu rophysiologieal Changes in Experimental Selective Lumbar Spinal nerve Root Compression in a Feline Model

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中国临床神经科学 2000年第Z1期8卷 93-页

作者： Zhou Hui XH He HK Wong Department of Neurology Chang Zheng Hospital Shanghai China Department of Orthopaedic Surgery National University of Singapore Department of Orthopaedic Surgery National University of Singapore

　　The spinal nerve root may be subjected to compression in a variety of clinical conditions which may lead to disabling leg pain and disability. The objective documentation of the clinical symptoms by electrophysiological tests could be procedure dependent. In the experimental study of nerve root compression in animal models, electrophytsiological tests are one of the few available methods to assess the effects of in nerve root compression. The purpose of this study is to evaluate the effects of compression of the spinal nerve root on the motor conduction velocity(MCV) and cortical somatosensory evoked potentials(SCEP) over a period of 6 weeks in a feline model. Ten cats were used in this study. Under anaesthesia, a laminectomy at L6 and L7 was performed. The right L6 nerve root was exposed and compressed by a Surg i-loop around nerve root and maintained by a Ligacap. MCV was recorded by stimulating the proximal end of nerve root before and after compression. Stimulating the right posterior tibial nerve and recording at the skull performed CSEP. After nerve root compression, MCV showed a significant reduction of amplitudes (immediate:64 ± 11%; 3-week: 73± 13%; 6-week: 73± 12% p＜0.01 ) . The lateneies of MCV were not significant changed. The amplitudes of CSEP were also reduced significantly (immediate:56±9%; 5-minute:74± 12%). The N1 peak disappeared and latencies prolonged. We conclude that amplitude changes of MCV and CSEP could be used for diagnosis of acute peripheral nerve injury in the feline model, which may have clinical implication.

关键词： nerve root peripheral nerve injury experimental study evoked potentials animal models tibial nerve used in

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