检索结果-南通市图书馆

Expression of thyroid transcription factor-1(TTF-1)in Lung Carcinomas and Its Correlations with Apoptosis and Angiogenesis

引用

Chinese Journal of Clinical Oncology 2009年第1期6卷 16-20页

作者： Xiaoyan Bai Hong Shen Chunhui Zhou Hao Wang Department of Pathology School of BasicMedical Sciences Southern Medical University Guangzhou 510515 China.

OBJECTIVE To investigate the correlations between the expression of thyroid transcription factor-1 （TTF-1） and apoptosis and angiogenesis in lung carcinomas. METHODS A 829 microarray of the paraffin tissue chips was constructed, which contained 196 lung carcinomas, 10 normal lung tissues, and 1 muscular tissue. Terminal deoxynucleotidyl transferase mediated nick end labeling （TUNEL） and immunohistochemical SP method were used to detect apoptosis and expression of TTF-1 and CD34 in different types of lung carcinomas. A Leica Q500 MC image analysis system was used to measure and calculate TTF-1 positive unit （PU）, apoptotic index （AI） and microvessel density （MVD）. RESULTS AI of lung small cell carcinoma and large cell carcinoma were smaller than those of lung adenocarcinoma and squamous cell carcinoma （P = 0.000）. AI of lung carcinomas with lymph node metastases was smaller than that of those without （P = 0.039）. AI of lung carcinomas in TNM stage I-IV was smaller than that in stage I （P = 0.008）. The PU of the TTF-1 was negatively correlated with AI in small cell lung carcinoma （r = -0.752, P = 0.000）. MVD of lung carcinomas without lymph node metastases was smaller than that of those with lymph node metastasis （P = 0.031）. MVD of lung carcinomas in TNM stage I was smaller than that in stage I-IV （P = 0.040）. The PU of TTF-1 was positively correlated with MVD in lung adenocarcinoma （r = 0.708, P = 0.000）. CONCLUSION There is a negative correlation between TTF-1 PU and AI in small cell lung carcinoma. TTF-1 PU and AI may be correlated with each other. There is a positive correlation between TTF-1 PU and MVD in lung adenocarcinoma. TTF-1 may induce the development of lung adenocarcinoma by inducing tumor angiogenesis.

关键词： lung carcinoma thyroid transcription factor-1 tissue chip apoptosis angiogenesis.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Foregut duplication cysts:A report of two cases with emphasis on embryogenesis

引用

World Journal of Gastroenterology 2011年第1期17卷 130-134页

作者： Thaer Khoury Louis Rivera Department of Pathology Roswell Park Cancer InstituteBuffaloNY 14263United States Surgical Oncology Roswell Park Cancer InstituteBuffaloNY 14263United States

Duplication cyst of the stomach with a pseudostratifie columnar ciliated epithelium is extremely *** de scribe two cases of these cysts,with emphasis on the immunophenotype and *** first patien was a 29-year-old man who presented with crampin abdominal pain in his left lower *** secon patient was a 26-year-old woman who had a history over several years,of chronic epigastric abdominal pai radiating to her *** lesions were surgically re *** showed the same *** cysts were lined by a pseudostratified respiratory ep thelium with ciliated *** first cyst was connecte to the stomach,while the second cyst was not connect *** cysts expressed thyroid transcription factor(TTF-1) and *** this report,we explore th possible embryogenesis of these lesions in the light o TTF-1 and surfactant expression.

关键词： Duplication cyst Stomach thyroid transcription factor-1 Surfactant Embryogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：