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Earlier application of loading doses of aspirin and clopidogrel decreases rate of recurrent cardiovascular ischemic events for patients undergoing percutaneous coronary intervention

引用

Chinese Medical Journal 2012年第4期125卷 631-638页

作者： Tang Fa-kuan Lin Le-jian Hua Ning Lu Hong Qi Zhi Tang Xue-zheng Chinese Peoples Liberat Army Hosp 309 Dept Cardiol Beijing 100091 Peoples R China

Background Aspirin and clopidogrel resistance plays a significant role in the development of cardiovascular ischemic events for ninety patients undergoing percutaneous coronary *** studies have indicated that increasing the dose of antiplatelet drugs maybe a potent method to improve the inhibition of platelet *** thrombelastograph （TEG） determinations were used to evaluate the effect of antiplatelet *** to the results,90 patients were divided into three groups and given different doses of aspirin and *** patients with both an inhibition rate of aspirin 〉50% and an inhibition rate of clopidogrel 〉50% were defined as the control *** patients with an inhibition rate for aspirin 〈50% and an inhibition rate for clopidogrel 〈50% were defined as the resistance *** in resistance group were randomly assigned to be given a routine dose （100 mg aspirin plus 75 mg clopidogrel per day,which we called a resistance plus routine dose group,R＋R） and a loading dose （200 mg aspirin and 150 mg clopidogrel per day,which we called resistance plus loading dose group,R＋L） of antiplatelet therapy.A 12-month follow-up was observed to examine the change of inhibition rate of antiplatelet therapy and to estimate the relationship between inhibition rate and the occurrence of cardiovascular ischemic *** After 6 months of antiplatelet therapy,the inhibition rate of aspirin in the R＋L group increased from （31.4±3.7）% to （68.6±7.1）%,which was significantly higher than that in R＋R group,（51.9±8.2）% （P 〈0.01）.The inhibition rate of clopidogrel in the R＋L group increased from （22.1±3.8）% to （60.2±7.4）%,which was significantly higher than in the R＋R group,（45.9±4.3）% （P 〈0.01）.The occurrence rates of cardiovascular ischemic events,stent thrombosis,recurrent unstable angina and myocardial infarction in the R＋R group were 20%,36% and 17%,*** was significantly increased compared with that in the

关键词： aspirin resistance clopidogrel resistance thrombelastograph percutaneous coronary intervention cardiovascular ischemic events

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