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作者：申博锦州医科大学

学位级别：硕士

背景众所周知,急性缺血性卒中(acute ischemic stroke,AIS)具有较高的致残率和病死率。目前,国际上公认的预测AIS不良预后的常用量表如thrive、iScore和ASTRAL,已有较多的临床研究证明其的有效性,但其在我国AIS患者中的预测价值尚有待... 详细信息

背景众所周知,急性缺血性卒中(acute ischemic stroke,AIS)具有较高的致残率和病死率。目前,国际上公认的预测AIS不良预后的常用量表如thrive、iScore和ASTRAL,已有较多的临床研究证明其的有效性,但其在我国AIS患者中的预测价值尚有待于进一步验证。目的探讨thrive、iScore和ASTRAL量表对AIS患者1年时不良预后结局的预测价值。方法纳入2012年12月1日至2016年9月30日住院治疗的AIS患者772例,收集患者临床基线资料,同时应用thrive、iScore和ASTRAL 3个量表进行评分,并进行前瞻的队列随访研究,随访1年,以患者1年时出现死亡或功能残障(改良Rankin评分>2分)作为不良结局事件,以1年改良Rankin评分≥5分作为重度残障结局,使用受试者工作特征曲线下面积(the receiver operating characteristic area under the curve,AUC)比较3个量表的预测价值;应用Hosmer-Lemeshow拟合优度检验评价各模型的拟合度;应用Pearson相关分析评估实际与预期结局事件的关联程度。结果本研究共纳入AIS患者772例,在1年随访时出现不良结局196例(25.4%),其中包括死亡68例(34.7%)。thrive、iScore和ASTRAL量表预测AIS患者1年不良预后的AUC值分别为0.777[95%CI,(0.738,0.815)]、0.831[95%CI,(0.796,0.865)]、0.860[95%CI,(0.830,0.890)](均Pthrive量表的AUC值低于iScore和ASTRAL量表,且差异有统计学意义(P0.05)。进而应用Pearson相关分析,相关系数分别为0.985、0.693和0.620(均Pthrive量表的AUC值低于iScore量表,差异有统计学意义(Pthrive量表的AUC值低于iScore量表,差异有统计学意义(Pthrive、iScore和ASTRAL量表均可对我国AIS人群的1年不良预后进行预测,但是iScore和ASTRAL量表的预测效能更好,有助于临床的早期干预;同时,iScore量表在预测我国卒中人群重度残障及死亡结局时亦有很好的适用性。

关键词：急性缺血性卒中 thrive iScore ASTRAL 预测预后

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3T磁共振thrive技术在腹部疾病中应用价值

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中国医疗设备 2011年第6期26卷 16-17,13页

作者：王雪梅邴晶谭晓天大连市中心医院放射科辽宁大连116033

目的探讨3T MR thrive(T1 High Resolution Isotropic Volume Examination)技术在腹部疾病中的应用价值。方法采用thrive序列对67例腹部疾病进行扫描,分析其应用价值。结果 thrive技术发现肝胆胰脾病变45例,肾及肾上腺病变10例,腹主动... 详细信息

目的探讨3T MR thrive(T1 High Resolution Isotropic Volume Examination)技术在腹部疾病中的应用价值。方法采用thrive序列对67例腹部疾病进行扫描,分析其应用价值。结果 thrive技术发现肝胆胰脾病变45例,肾及肾上腺病变10例,腹主动脉瘤2例,原发性腹膜后肿瘤5例,盆腔内卵巢及阴囊肿瘤各1例,胃癌和结肠癌各1例,腹腔脓肿1例。阳性率约为97.1%。有2例在thrive技术中病灶没能显示,阴性率约为2.9%。结论 MRI thrive技术的特点是空间分辨率高,扫描范围大、速度快,具有良好的脂肪抑制作用,在腹部疾病检查中能够满足临床的诊断需要。

关键词：磁共振腹部疾病 thrive

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东芝thrive平板电脑配Android3.1

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办公自动化 2011年第13期 28-28页

谷歌近期发布里一款平板电脑升级系统Android3.1,很多厂商宣布了产品的升级方案。与Android3.0相比,Android3.1的界面进行了调整与美化,支持可改变大小的widget工具,增加了多个内置应用程序,同时对WIFI、USB、邮件等功能进行了优化。该... 详细信息

谷歌近期发布里一款平板电脑升级系统Android3.1,很多厂商宣布了产品的升级方案。与Android3.0相比,Android3.1的界面进行了调整与美化,支持可改变大小的widget工具,增加了多个内置应用程序,同时对WIFI、USB、邮件等功能进行了优化。该系统升级后最大的一项改进就是,原来在Android3.0上无法兼容的大多数的An-droid 2.X版本的应用程序,在Android3.1可以得到更多的应用。

关键词：平板电脑 Android3.1 thrive

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Extra-intestinal and long term consequences of Giardia duodenalis infections

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World Journal of Gastroenterology 2013年第47期19卷 8974-8985页

作者： Marie CM Halliez André G Buret Department of Biological Sciences Inflammation Research NetworkUniversity of CalgaryCalgaryAlbertaAB T2N 1N4Canada Parasitology Department Rouen University Hospital & EA 3800 Institute for Biomedical & Research University of RouenRouen76183France

Giardiasis is the most common waterborne parasitic infection of the human intestine *** etiological agent,Giardia duodenalis(***,***),is a flagellated,binucleated protozoan parasite which infects a wide array of mammalian *** giardiasis is a true cosmopolitan pathogen,with highest prevalence in developing *** can present with a broad range of clinical manifestations from asymptomatic,to acute or chronic diarrheal disease associated with abdominal pain and *** infections are self-limiting,although re-infection and chronic infection can *** evidence indicating that Giardia may cause chronic post-infectious gastrointestinal complications have made it a topic of intense *** causes of the post-infectious clinical manifestations due to Giardia,even after complete elimination of the parasite,remain *** review offers a state-of-the-art discussion on the long-term consequences of Giardia infections,from extra-intestinal manifestations,growth and cognitive deficiencies,to post-infectious irritable bowel *** discussion also sheds light on some of the novel mechanisms recently implicated in the production of these postinfectious manifestations.

关键词： Giardiasis Inflammatory disorders Extraintestinal manifestations of enteritis Failure to thrive Post-infectious irritable bowel syndrome

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Microfossils and molecular records in oil shales of the Songliao Basin and implications for paleo-depositional environment

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Science China Earth Sciences 2009年第10期52卷 1559-1571页

作者： FENG ZiHui FANG Wei WANG Xue HUANG ChunYan HUO QiuLi ZHANG JuHe HUANG QingHua ZHANG Lei School of Earth and Space Sciences Peking UniversityBeijing 1000871China Exploration and Development Research Institute PetroChina Daqing Oilfield Company Ltd.Daqing 163712China

Several oil shale beds, over 10 m thick, occur at the base of the first member of the Upper Cretaceous Qingshankou Formation (K2qn1) in the Songliao Basin. They act both as excellent source rocks for conventional oil and as potential oil deposit for shale oil production. Here we combine micropaleon-tology with organic geochemistry to investigate the paleo-depositional environment and organic source characteristics of the oil shales and black shales. Our results indicate that algal remains are dominant microfossils in K2qn1 oil shales, and their relatively high abundance suggests a major algal thriving event during the oil shale deposition. The presence of fresh water and brackish water species, Sentusidinium, Vesperopsis and Nyktericysta, and marine or brackish water deltaic and lagoonal species such as Kiokansium and Dinogymniopsis demonstrate that this paleo-continental lake was influenced by marine transgressions at the time of K2qn1 oil shale formation. The extremely low pristine/phytane ratios, relatively high abundance of gammacerane and 4-methyl steranes, and low δ 13C values of C14-C37 n-alkanes in the oil shale organic extracts indicate the deposition of oil shales in anoxic and highly stratified water columns and the significant contribution of lacustrine algae to sedimentary organic matter. High molecular-weight paraffinic hydrocarbons with unusually high abundance of nC43, nC45, and nC47 may be related to special algal species associated with marine transgression events. The giant water body of Songliao paleo-lake and the change in the organic and chemical environment (such as nutrition source and water column salinity) associated with seawater transgression into the lake are among the most important reasons for oil shales in the Songliao Basin being different from mudstone and oil shale in other rifted basins.

关键词： Songliao Basin oil shale micro-fossil molecular fossil alga thrive event

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Magnetic resonance imaging of the liver:New imaging strategies for evaluating focal liver lesions

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World Journal of Radiology 2009年第1期1卷 72-85页

作者： Kenneth Coenegrachts Department of Radiology AZ St.-Jan Brugge-Oostende AVRuddershove 10B-8000 BrugesBelgium Author contributions:Coenegrachts K contributed solely to this paper

The early detection of focal liver lesions,particularly those which are malignant,is of utmost *** resection of liver metastases of some malignancies(including colorectal cancer)has been shown to improve the survival of *** knowledge of the number,size,and regional distribution of liver metastases is essential to determine their *** all focal liver lesions larger than 10 mm are demonstrated with current imaging techniques but the detection of smaller focal liver lesions is still relatively *** of the advantages of magnetic resonance imaging(MRI)of the liver is better soft tissue contrast(compared to other radiologic modalities),which allows better detection and characterization of the focal liver lesions in *** in MRI hardware and software and the availability of novel MRI contrast agents have further improved the diagnostic yield of MRI in lesion detection and *** the primary modalities for liver imaging are ultrasound and computed tomography,recent studies have suggested that MRI is the most sensitive method for detecting small liver metastatic lesions,and MRI is now considered the pre-operative standard method for *** recent developments in MRI sequences for the upper abdomen comprise unenhanced diffusion-weighted imaging(DWI),and keyhole-based dynamic contrast-enhanced(DCE)MRI(4D thrive).DWI allows improved detection(b=10 s/mm2)of small(thrive enables MRI of the liver with high temporal and spatial resolution and full liver coverage.4D thrive improves evaluation of focal liver lesions,providing multiple arterial and venous phases,and allows the calculation of perfusion parameters usi

关键词： Magnetic resonance imaging Liver neoplasms Diffusion-weighted magnetic resonance imaging 4D thrive Dynamic contrast-enhanced magnetic resonance imaging Contrast agents

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