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Toward point-of-care management of chronic respiratory conditions:Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide

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Microsystems & Nanoengineering 2017年第1期3卷 286-293页

作者： Azam Gholizadeh Damien Voiry Clifford Weisel Andrew Gow Robert Laumbach Howard Kipen Manish Chhowalla Mehdi Javanmard Department of Electrical and Computer Engineering Rutgers UniversityPiscatawayNJ 08854USA Department of Material Science and Engineering Rutgers UniversityPiscatawayNJ 08854USA Environmental Occupational Health Sciences Institute Rutgers UniversityPiscatawayNJ 08854USA School of Pharmacy Rutgers UniversityPiscatawayNJ 08854USA

We present a portable non-invasive approach for measuring indicators of inflammation and oxidative stress in the respiratory tract by quantifying a biomarker in exhaled breath condensate(EBC).We discuss the fabrication and characterization of a miniaturized electrochemical sensor for detecting nitrite content in EBC using reduced graphene *** nitrite content in EBC has been demonstrated to be a promising biomarker of inflammation in the respiratory tract,particularly in *** utilized the unique properties of reduced graphene oxide(rGO);specifically,the material is resilient to corrosion while exhibiting rapid electron transfer with electrolytes,thus allowing for highly sensitive electrochemical detection with minimal *** rGO sensor was housed in an electrochemical cell fabricated from polydimethyl siloxane(PDMS),which was necessary to analyze small EBC sample *** sensor is capable of detecting nitrite at a low over-potential of 0.7 V with respect to an Ag/AgCl reference *** characterized the performance of the sensors using standard nitrite/buffer solutions,nitrite spiked into EBC,and clinical EBC *** sensor demonstrated a sensitivity of 0.21μAμM^(−1) cm^(−2) in the range of 20–100μM and of 0.1μAμM^(−1) cm^(−2) in the range of 100–1000μM nitrite concentration and exhibited a low detection limit of 830 nM in the EBC *** benchmark our platform,we tested our sensors using seven pre-characterized clinical EBC samples with concentrations ranging between 0.14 and 6.5μ*** enzyme-free and label-free method of detecting biomarkers in EBC can pave the way for the development of portable breath analyzers for diagnosing and managing changes in respiratory inflammation and disease.

关键词： exhaled breath condensate nitrite electrochemistry square wave voltammetry thin-layer-reduced graphene oxide

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