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Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of SZ-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis

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Chinese Chemical Letters 2024年第6期35卷 462-468页

作者： Yu Yan Jiawei Song Dongdong Liu Zihan Liu Jialing Cheng Zhiyang Chen Yanfang Yang Weizhe Jiang Hongliang Wang Jun Ye Yuling Liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China College of Pharmacy Guangxi Medical UniversityNanning 530021China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Ulcerative colitis(UC)is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon and disrupted intestinal *** mori(Sangzhi)alkaloids(SZ-A),derived from twigs of mulberry,were approved by the National Medical Products Administration in 2020 for treating type 2 diabetes *** evidence has confirmed that SZ-A also alleviates non-alcoholic fatty liver disease and ameliorates inflammation,indicating its potential to address inflammation in ***,the treatment of UC faces challenges due to low drug delivery efficiency and short retention *** overcome these challenges,an injectable and adherent in-situ thermo-sensitive hydrogel containing SZ-A was developed for rectal drug delivery,utilizing the thermo-sensitive polymers Poloxamer 407and *** thermo-sensitive hydrogel system was designed with a moderate gelation temperature of 32±0.5℃,a short gelation time of 64 s,a p H range of 7-10,high moisturizing capability exceeding 90%,and moderate mechanical strength of 4-5 *** a rat model with UC,the in situ thermo-sensitive hydrogel significantly extended the retention time at the colonic site and enabled sustained release after rectal *** of UC were markedly reduced following rectal administration of SZ-A thermosensitive ***,the release of inflammatory factors,such as interleukin-1β(IL-1β),IL-6,IL-18,tumor necrosis factor-α(TNF-α),and transforming growth factor-β1(TGF-β1),significantly decreased in the SZ-A thermo-sensitive hydrogel *** integrity of the colonic mucosal barrier was significantly enhanced following the application of SZ-A thermo-sensitive *** conclusion,rectal administration of SZ-A in situ thermo-sensitive hydrogel effectively alleviated UC symptoms,inhibited the secretion of inflammatory factors,and promoted the repair of the colonic mucosal *** approach holds promise as a potential treatment for UC.

关键词： Ulcerative colitis SZ-A thermo-sensitive hydrogel Rectal administration Alleviation of inflammation Mucosal barrier repair

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Sustained co-delivery of 5-fluorouracil and cis-platinum via biodegradable thermo-sensitive hydrogel for intraoperative synergistic combination chemotherapy of gastric cancer

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Bioactive Materials 2023年第5期23卷 1-15页

作者： Wen Chen Kun Shi Jie Liu Peipei Yang Ruxia Han Meng Pan Liping Yuan Chao Fang Yongyang Yu Zhiyong Qian State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation CenterChengdu610041PR China Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu610041PR China

Gastric cancer is the fifth most common cancer and the third leading cause of cancer death worldwide,posing a severe threat to human *** resection remains the most preferred option for gastric cancer ***,for advanced gastric cancer,the curative effect of surgical resection is usually limited by the local recurrence,peritoneal carcinomatosis,or distal *** chemotherapy is an attractive in situ adjuvant treatment strategy to reduce the recurrence and metastasis after surgical ***,we designed a 5-fluorouracil(5-FU)and cis-platinum(DDP)co-delivery system based on a biodegradable temperature-sensitive hydrogel(PDLLA-PEG-PDLLA,PLEL)for intraoperative adjuvant combination chemotherapy of gastric *** 5-FU+DDP/PLEL hydrogel system characterized by a special sol-gel phase transition in response to physiological temperature and presented sustained drug release in vitro and in vivo.A strong synergistic cell proliferation inhibition and apoptosis promotion of 5-FU+DDP/PLEL were observed against gastric cancer MKN45-luc *** intraperitoneal injection,the dual-drug loaded hydrogel formulation showed superior anti-tumor effects than the single-drug carrying hydrogels and combination of free 5-FU and DDP on the gastric cancer peritoneal carcinomatosis *** use of hydrogel for dual-drug delivery had benefited to fewer side effects as ***’s more,we established a mouse model for postsurgical residual tumors and peritoneal carcinomatosis of gastric cancer,in which the intraoperative administration of 5-FU+DDP/PLEL also remarkably inhibited the local recurrence of the orthotopic tumors and the growth of the abdominal metastatic tumors,resulting in an extended ***,this developed dual-drug loaded hydrogel system has great potential in the intraoperative chemotherapy of gastric cancer,that suggests a clinically-relevant and valuable option for postsurgical management of gastric cancer.

关键词： thermo-sensitive hydrogel Localized drug delivery Sustained release Intraoperative chemotherapy Gastric cancer

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Controlled release behaviors of chitosan/α,β- glycerophosphate thermo-sensitive hydrogels

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Frontiers of Materials Science 2012年第3期6卷 250-258页

作者： Wei-Fang LIU Chuan-Zhen KANG Ming KONG Yang LI Jing SU An YI Xiao-Jie CHENG Xi-Guang CHEN College of Marine Life Science Ocean University of ChinaQingdao 266003China The Affiliated Hospital of Medical College Qingdao UniversityQingdao 266001China

Chitosan/α,β-glycerophosphate （CS/α,β-GP） thermo-sensitive hydrogels presented flowable solution state at low temperature and semisolid hydrogel when the ambient temperature increased. In this research, different concentrations of metronida- zole encapsulated, CS and α,β-GP, as well as different acid solvents, were chosen to evaluate their influences on the drug release behaviors from CS/α,β-GP hydrogels. It was found that there was a sustaining release during the first 3 h followed by a plateau. SEM images showed that drugs were located both on the surface and in the interior of hydrogels. The optimal preparation conditions of this hydrogel for drug release were as follows： 1.8% （w/v） CS in HAc solvent, 5.6% （w/v） a, 13-GP and 5g/L metronidazole encapsulation. Cytotoxicity evaluation found no toxic effect. In order to control the release rate, 2.5 g/L chitosan microspheres with spherical shape and smooth surface were incorporated, and it was found that the initial release process was alleviated, while drug concentration had no obvious effect on the release rate. It could be concluded that the metronidzole release behaviors could be optimized according to practical applica- tions.

关键词： chitosan (CS) glycerophosphate (GP) thermo-sensitive hydrogel con-trolled release microsphere

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Intratympanic injection of hydrogel nanodrug for the prevention and treatment of sensorineural hearing loss

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中华耳科学杂志:英文版 2023年第4期18卷 235-239页

作者： Tianying Zhai Pingping Ai Zhaohui Tang Chaoliang He Xuesi Chen Shiming Yang Nan Wu Senior Department of Otolaryngology-Head&Neck Surgery PLA General HospitalBeijingChina National Clinical Research Center for Otolaryngologic Disease BeijingChina State Key Lab of Hearing Science Ministry of EducationBeijingChina Beijing Key Lab of Hearing Impairment Prevention&Treatment BeijingChina Zhejiang Chinese Medical University HangzhouChina Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchunChina

Safe and efficient drug delivery to the inner ear has always been the focus of prevention and treatment of sensorineural *** rapid development of nanodrug delivery systems based on hydrogel has provided a new *** them,thermo-sensitive hydrogels promote the development of new dosage form for intratympanic *** smart biomaterial could transform to semisolid phase when the temperature ***-sensitive hydrogel nanodrug delivery system is expected to achieve safe,efficient,and sustained inner ear drug *** article introduces the key techniques and the latest progress in this field.

关键词： thermo-sensitive hydrogel Nanodrug Sensorineural hearing loss Intratympanic injection

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Preparation and Characterization of Chitosan/β-GP Membranes for Guided Bone Regeneration

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Journal of Wuhan University of Technology(Materials Science) 2011年第2期26卷 242-246页

作者：崔军徐欣孙康宁 Department of Dental Implant Center School of StomatologyShandong University Shandong Provincial Key Lab Dral Biomedicine School of Materials Science and Engineering Shandong University

Bioabsorbable chitosan/β-glycerol phosphate （CS/β-GP） composite membranes were fabricated through a relatively PH neutral and mild sol-gel process for guided bone regeneration （GBR）.Their structural properties,morphology,and tensile strength were *** and XRD analyses indicated that there were chemical bonds between the CS andβ-*** analysis revealed that the CS/β-GP composite membranes had a porous structure both at the surface and in *** though the incorporation ofβ-GP in the CS matrix decreased the initial tensile strength of the membrane,the CS/β-GP membranes were still fit for GBR application with their tensile strength of roughly *** concentration ofβ-GP was proportional to the pore size and thickness but was inversely proportional to the tensile strength of the CS/β-GP *** present findings indicate that,based on its characteristics,the CS/β-GP composite membrane is a potential bioresorbable membrane for use in guided bone regeneration.

关键词： chitosan β-glycerol phosphate guided bone regeneration membrane thermo-sensitive hydrogel

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基于壳聚糖的可注射复合水凝胶的制备及其性能研究

基于壳聚糖的可注射复合水凝胶的制备及其性能研究

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中国化学会第十七届全国胶体与界面化学学术会议

作者：施冬健石畅曾金凤陈明清食品胶体与生物技术教育部重点实验江南大学化学与材料工程学院

＜正＞目前,刺激响应性的高分子纳米载体常被用于肿瘤的治疗,但用于肿瘤治疗的药物运输系统存在一些问题,如在体内的非特异性分布以及被快速地清除体外等问题[1]。水凝胶作为一种局部给药系统,能够固定在病灶位置持续有效的释放药物,可... 详细信息

＜正＞目前,刺激响应性的高分子纳米载体常被用于肿瘤的治疗,但用于肿瘤治疗的药物运输系统存在一些问题,如在体内的非特异性分布以及被快速地清除体外等问题[1]。水凝胶作为一种局部给药系统,能够固定在病灶位置持续有效的释放药物,可以根据疾病的恶化程度选择药物的负载量以及停留时间,有效的解决上述问题[2]。基于纳米材料的光热治疗（PTT）是近年来迅速发展的一种微创肿瘤治疗技术,光敏剂在肿瘤部位积累,在入射光的激发下,

关键词： thermo-sensitive hydrogel photo-thermal therapy Au nanoparticles

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