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The role of gut microbiota in the gut-brain axis:current challenges and perspectives

Protein & Cell 2013年第6期4卷 403-414页

作者： Xiao Chen Roshan D’Souza Seong-Tshool Hong BDRD Research Institute JINIS Biopharmaceuticals Inc948-9 DunsanBongdongWanjuChonbuk 565-902South Korea Department of Microbiology and Genetics and Institute for Medical Science Chonbuk National University Medical SchoolJeonju 561-712South Korea

brain and the gastrointestinal(GI)tract are intimately con-nected to form a bidirectional neurohumoral communica-tion *** communication between gut and brain,knows as the gut-brain axis,is so well established that the functional status of gut is always related to the condi-tion of *** researches on the gut-brain axis were traditionally focused on the psychological status affecting the function of the GI ***,recent evidences showed that gut microbiota communicates with the brain via the gut-brain axis to modulate brain development and behavioral *** recent fi ndings on the new role of gut microbiota in the gut-brain axis implicate that gut microbiota could associate with brain functions as well as neurological diseases via the gut-brain *** elucidate the role of gut microbiota in the gut-brain axis,precise identification of the composition of microbes constituting gut microbiota is an essential ***,identifi cation of microbes constituting gut microbiota has been the main technological challenge currently due to massive amount of intestinal microbes and the diffi culties in culture of gut *** methods for identifi ca-tion of microbes constituting gut microbiota are depend-ent on omics analysis methods by using advanced high tech ***,we review the association of gut microbiota with the gut-brain axis,including the pros and cons of the current high throughput methods for identi-fi cation of microbes constituting gut microbiota to eluci-date the role of gut microbiota in the gut-brain axis.

关键词： gut microbiota the gut-brain axis central nervous system high throughput methods next-generation sequencings

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To explore the research progress of acupuncture in the treatment of stroke based on the function of intestinal flora

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Microenvironment & Microecology Research 2022年第4期4卷 1-6页

作者： Yi-Jun Feng Rui Jin Bing-Quan Wang Dong-Jian Hu Yue-Qiao Ren Jun Wu Yin-Tao Zhang Chu-Yi Zhang Zhen Zhou Graduate school Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Traditional Chinese Medicine Tianjin Children's HospitalTianjin 300134China Department of Acupuncture and Moxibustion Second Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250China

gut microbiota is a microecosystem composed of microbes in the gut,and each microbiota participates in maintaining various functions of the human body by achieving ecological *** number and structure of gut microbiota change after stroke,which causes a series of reactions and aggravates brain *** can promote the recovery of nerve function by correcting the disorder of intestinal *** study illustrates multiple potential mechanisms of acupuncture in the treatment of stroke by interfering with gut microbiota,aiming to provide new ideas for the prevention and treatment of stroke.

关键词： acupuncture gut microbiota stroke the gut-brain axis review

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