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Expression of nuclear factor-KB in hepatocellular carcinoma and its relation with the x protein of hepatitis B virus

引用

World Journal of Gastroenterology 2001年第3期7卷 340-344页

作者： Shuang Ping Guo~1 Wen Liang Wang~1 Yu Qiang Zhai~2 Yi Ling Zhao~1 ~1Department of Pathology,xijing Hospital of the Fourth Military Medical University,xi’an,China ~2Department of Urology,the Central Hospital of xi’an,China Department of Pathology Xijing Hospital of the Fourth Military Medical University Xi'an China. guoshuangping@***

AIM In this study we investigated the relationship of the x protein of hbv and nuclear factor-κB(NF-κB)and the expression of NF-κB in human hepatocellular carcinoma tissues. METHODS Immunohistochemistry SP method was used to detect the expression of NF-κB and the x protein of hbv in human hepatocellular carcinoma tissues of 52 *** transfection mediated by lipofectamine was used to transfect the eukaryotic expression vector pCDNA3.1-HBx of hbv x gene into human hepatocellular carcinoma cell line HCC-9204 and NF-κB was detected. RESULTS NF-κB was widely expressed in human hepatocellular carcinoma tissues in a total of 52 cases and its expression was related to the x protein of ***-κB was localized both in the cytoplasm and the nuclei of hepatocellular carcinoma cells in 11 cases which were positive for the x protein of hbv while in 41 cases negative for the x protein of hbv,NF-κB was only localized in the cytoplasm of hepatocellular carcinoma cells but translocated to the nuclei of hepatocellular carcinoma cells after the eukaryotic expression vector pCDNA3.1-HBx was transfected into HCC-9204 cells. CONCLUSION This study strongly suggests that the nuclear factor NF-κB is widely expressed in hepatocellular carcinoma tissues in different styles according to the expression of the x protein of ***-κB is abnormally activated in hepatocellular carcinoma,which is probably rélated to the x protein of *** x protein of hbv can activate NF-κB to translocate into nuclei of hepatocellular carcinoma cells.

关键词： the x protein of hbv nulcear factor-KB hepatocellular carcinoma cell

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