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testicular exosomes disturb the immunosuppressive phenotype of testicular macrophages mediated by miR-155-5p in uropathogenic Escherichia coli-induced orchitis

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Asian Journal of Andrology 2023年第3期25卷 389-397页

作者： Jia Xu Chao He Yi-Wei Fang Zhi-Yong Hu Mei-Lin Peng Yuan-Yao Chen Yu-Fang Su Chun-Yan Liu Hui-Ping Zhang Kai Zhao Institute of Reproductive Health Center for Reproductive MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Male reproductive infections are known to shape the immunological homeostasis of the testes,leading to male ***,the specific pathogenesis of these changes remains poorly *** released in the inflammatory microenvironment are important in communication between the local microenvironment and recipient ***,we aim to identify the immunomodulatory properties of inflammatory testes-derived exosomes(IT-exos)and explore their underlying mechanisms in ***-exos were isolated using a uropathogenic Escherichia coli(UPEC)-induced orchitis model and confirmed that IT-exos promoted proinflammatory M1 activation with increasing expression of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and interleukin-6(IL-6)in *** further used small RNA sequencing to identify the differential miRNA profiles in exosomes and primary testicular macrophages(TMs)from normal and UPEC-infected testes,respectively,and identified that miR-155-5p was highly enriched in IT-exos and TMs from inflammatory *** study of bone marrow derived macrophages(BMDMs)transfected with miR-155-5p mimic showed that macrophages polarized to proinflammatory *** addition,the mice that were administrated IT-exos showed remarkable activation of TM1-like macrophages;however,IT-exos with silencing miR-155-5p showed a decrease in proinflammatory ***,we demonstrate that miR-155-5p delivered by IT-exos plays an important role in the activation of TM1 in UPEC-induced *** study provides a new perspective on the immunological mechanisms underlying inflammation-related male infertility.

关键词： male infertility miR-155-5p orchitis testicular exosome testicular macrophage polarization

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