检索结果-南通市图书馆

Differences of Efficacy Between tenofovir Alafenamide fumarate and tenofovir disoproxil fumarate in Pregnant Women With Different Hepatitis B Virus DNA Loads

引用

Infectious Microbes & Diseases 2024年第3期6卷 134-140页

作者： Chengjing Tao Guanlun Zhou Hongxiu Jiang Chao Chen Yuhao Ju Xingran Tao Ping Zhang Shuorong Liu Guorong Han Department of Obstetrics and Gynecology the Second Hospital of NanjingAffiliated Hospital to Nanjing University of Chinese MedicineNanjingChina Department of Obstetrics and Gynecology Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhouChina Department of Hepatology Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhouChina

tenofovir alafenamide fumarate(TAF)has been endorsed by guidelines for blockade ofmother-to-child transmission of hepatitis B virus(HBV),given that its efficacy and safety are comparable to tenofovir disoproxil fumarate(TDF).However,there is a lack of comparative studies regarding the treatment efficacy in patients with diverse viral *** study retrospectively analyzed 96 hepatitis B e antigen(HBeAg)–positive pregnant women with HBV DNA levels of≥2×10^(5) IU/*** on viral loads(HBV DNA levels),participants in the TAF and TDF groups were stratified into three subgroups,namely,the High-G(titer≥8 log10 IU/mL),Middle-G(7 log10 IU/mL≤titer<8 log10 IU/mL)and Low-G(titer<7 log10 IU/mL)*** primary endpoint was effectiveness of TAF and TDF in patients with varying viral loads,whereas secondary endpoints were hepatitis B surface antigen(HBsAg)positivity in infants at 7 to 12 months and the safety profile for mothers and *** with baseline levels,median HBV DNA levels in mothers were decreased by 4.51 and 4.09 log10 IU/mL in the TAF andTDF groups(P=0.04)predelivery,*** the High-G subgroup,the titers were significantly lower in the TAF group(P=0.045).A higher proportion of patients experienced a virus decline of≥4 log10 IU/mL in the TAF group compared with the TDF group,with rates of 78.26% versus 58%(P=0.034),***,the median serum phosphate levels significantly decreased frombaseline to predelivery in the TDF group(P=0.04).Finally,infants in both cohorts tested negative for HBsAg at 7–12 months after ***,our findings indicate that TAF can be considered the preferred option for the treatment of HBeAgpositive pregnant women with HBV DNA levels of≥8 log10 IU/mL.

关键词： hepatitis B virus tenofovir alafenamide fumarate tenofovir disoproxil fumara HBeAg positive HBV DNA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：