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Advances in chemokines of teleost fish species

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Aquaculture and Fisheries 2024年第2期9卷 115-125页

作者： Hongsen Xu Fuguo Liu Hubei Key Laboratory of Animal Nutrition and Feed Science School of Animal Science and Nutritional EngineeringWuhan Polytechnic UniversityWuhan430023China Department of Biology Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA02139USA

In mammals,chemokines are a superfamily of cytokines that regulate cell migration or exert direct antimicrobial activity.The presence and organization of four invariant cysteine residues within the mature protein sequence can classify chemokines into four major subfamilies:CXC,CC,CX_(3)C,and XC.In teleost,a novel subfamily of chemokines named CX has been identified.Since the first report of a CC chemokine(CK1)in rainbow trout in 1998,the number of identified chemokine genes in different fish species has expanded dramatically.In this paper,we reviewed the chemokine genes that have been identified so far in teleost fish and their tissue expressions and responses post-stimulation.We also discussed the functions of fish chemokines based on currently available information and compared them to human chemokines.Additionally,we predicted the structures of trout chemokines for the first time,and we found that the structures of trout chemokines share significant similarities.Finally,the adjuvant effects of fish chemokines in aquaculture were also reviewed.Overall,this review will give us a better understanding of the chemokines of teleost fish.

关键词： Chemokines teleost

Evolutionary dynamics and conserved function of the Tudor domain-containing(TDRD)proteins in teleost fish

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Marine Life Science & Technology 2022年第1期4卷 18-30页

作者： Zeyu Liu Saisai Liu Shiyang Guo Wei Lu Quanqi Zhang Jie Cheng Key Laboratory of Marine Genetics and Breeding(Ocean University of China) Ministry of EducationQingdao266003China Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266237China Laboratory of Tropical Marine Germplasm Resources and Breeding Engineering Sanya Oceanographic InstitutionOcean University of ChinaSanya572000China

Tudor domain-containing(TDRD)proteins,the germline enriched protein family,play essential roles in the process of gametogenesis and genome stability through their interaction with the PIWI-interacting RNA(piRNA)pathway.Several studies have suggested the rapid evolution of the piRNA pathway in teleost lineages with striking reproductive diversity.However,there is still limited information about the function and evolution of Tdrd genes in teleost species.In this study,through genome wide screening,13 Tdrd family genes were identified in economically important aquaculture fish,including spotted sea bass(Lateolabrax maculatus),Asian sea bass(Lates calcarifer),and tongue sole(Cynoglossus semilaevis).With copy number,structure,phylogeny,and synteny analysis,duplication of Tdrd6 and Tdrd7,as well as loss of Stk31 and Tdrd10,were characterized in teleost lineages.Codon based molecular evolution analysis indicated faster evolution of teleost Tdrd genes than that in mammals,potentially associated with the accelerated evolution of the piRNA pathway in teleost lineages.The evolutionary diversity of Tdrd genes was also detected between different teleost lineages.RNA-seq analysis showed that most teleost Tdrd genes were dominantly expressed in gonads,particularly highly expressed in testis,such as Tdrd6,Tdrd7a,Tdrd9,Ecat8,and Tdrd15.The varied expression and evolutionary pattern between the duplicated Tdrd6 and Tdrd7 in teleosts may indicate their functional diversification.All these results suggest a conserved function of teleost Tdrd family in gametogenesis and the piRNA pathway,which could lay a foundation for the evolution of Tdrd genes and be helpful for further deciphering of Tdrd functions in teleosts.

关键词： Tudor domain PIWI interacting RNA Molecular evolution Gametogenesis teleost

Specific function and modulation of teleost monocytes/macrophages: polarization and phagocytosis

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Zoological Research 2019年第3期40卷 146-150页

作者： Xin-Jiang Lu Jiong Chen Laboratory of Biochemistry and Molecular Biology School of Marine Sciences Ningbo University Ningbo Zhejiang 315211 China Key Laboratory of Applied Marine Biotechnology of Ministry of Education Ningbo University Ningbo Zhejiang 315211 China

Macrophages exist in most tissues and play a variety of functions in vertebrates.teleost fish species are found in most aquatic environments throughout the world and are quite diverse for a group of vertebrate animals.Due to whole genome duplication and en vironme ntal adaptati on,teleost monocytes/macrophages possess a variety of different functions and modulations compared with those of mammals.A deeper understanding of teleost monocytes/macrophages in the immune system will not only help develop teleost-specific methods of disease prevention but will also help improve our understanding of the various immune mechanisms in mammals.In this review,we summarize the differences in polarizati on and phagocytosis of teleost and mammalian macrophages to improve our understanding of the various immune mechanisms in vertebrates.

关键词： teleost Monocytes/Macrophages Phagocytosis Cytokine producti on Comparative immunology

CRYSTALLINE-LIKE STRUCTURE IN teleost SPERM MEMBRANE

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Chinese Science Bulletin 1991年第10期36卷 867-872页

作者：管汀鹭杨毅 Institute of Developmental Biology Academia Sinica Beijing 100080 PRC Beijing Emergency Center

It is well known that proteins existing in the biomembrane usually appear to be dispersed and disordered. However, there are a few exceptions to proteins appearing to be ordered in the membrane. For example, mammalian spermatozoa are highly polarized cells. There is an acrosome in the front of the sperm head. Therefore, the head of sperm can be often divided into diverse structural domains. The membrane is differentiated

关键词： teleost sperm membrane crystalline optical diffraction.

Purinergic signaling systems across comparative models of spinal cord injury

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Neural Regeneration Research 2022年第3期17卷 2391-2398页

作者： Eva E.Stefanova Angela L.Scott Department of Pathology and Molecular Medicine McMaster UniversityHamiltonONCanada

Within the last several decades,the scientific community has made substantial progress in elucidating the complex pathophysiology underlying spinal cord injury.However,despite the many advances using conventional mammalian models,both cellular and axonal regeneration following spinal cord injury have remained out of reach.In this sense,turning to non-mammalian,regenerative species presents a unique opportunity to identify pro-regenerative cues and chara cterize a spinal cord microenvironment permissive to re-growth.Among the signaling pathways hypothesized to be dysregulated during spinal cord injury is the purinergic signaling system.In addition to its well-known role as energy currency in cells,ATP and its metabolites are small molecule neurotransmitte rs that mediate many diverse cellular processes within the central nervous system.While our unde rstanding of the roles of the purinergic system following spinal cord injury is limited,this signaling pathway has been implicated in all injury-induced secondary processes,including cellular death,inflammation,reactive gliosis,and neural regeneration.Given that the purinergic system is also evolutionarily conserved between mammalian and non-mammalian species,comparisons of these roles may provide important insights into conditions responsible for recovery success.Here,we compare the secondary processes between key model species and the influence of purinergic signaling in each context.As our understanding of this signaling system and pro-regenerative conditions continues to evolve,so does the potential for the development of novel therapeutic interventions for spinal cord injury.

关键词： cell death differenriation glia inflammation neurogenesis proliferation purinergic signaling reactive gliosis regeneration spinal cord injury teleost

Immunocytochemical identification and localization of APUD cells in the gut of seven stomachless teleost fishes

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World Journal of Gastroenterology 2000年第1期6卷 96-101页

作者： Pan QS Fang ZP Zhao YX College of Fisheries Huazhong Agricultural UniversityWuhan 430070Hubei ProvinceChina College of Animal Husbandry and Veterinary Medicine Huazhong Agricultural UniversityWuhan 430070Hubei ProvinceChina

AIM To study the cell types,localization,distribution density and morphology of APUDcells in the intestinal mucosa of stomachlessteleost fishes.METHOD By using the peroxidase-antiperoxidase complex(PAP)immunocytochemical staining technique theidentification,localization and morphology ofimmunoreactive(IR)endocrine cells seattered inthe intestinal mucosa of grass carp(Cyenopharyngodon idellus),black carp(Mylopharyngodon piceus)and common carp(Cyprinus carpio)were investigated with 20kinds of antisera prepared against mammalianpeptide hormones of APUD cells,and likewise byusing avidin-biotin-peroxidase complex(ABC)method those of silver carp(Hypophthalmichthys molitrix),bighead(Aristichthys nobilis),silver crucian carp(Carassius gibelio)and bluntnose black bream(Megalobrama amblyocephala)were alsostudied with 5 different antisera.Thereplacement of the first antiserum by phosphatebuffered saline(PBS)was employed as a control.IR endocrine cells were counted with asquare-mesh ocular micrometer from 10 fieldsselected randomly in every section of each partof the intestine specimen.The average numberof IR endocrine cells per mm2 was counted toquantify their distribution density.RESULT Gastrin(GAS)-,Gastric inhibitorypeptide(GIP)-,glucagon(GLU)-,glucagon-likeimmunoreactants(GLI)-,bovine pancreaticpolypeptide(BPP)-,leucine-enkephalin(ENK)-and substance P(SP)-IR endocrine cells werefound in the gut of grass carp,black carp andcommon carp,and somatostatin(SOM)-IRendocrine cells were only seen in common carp.GAS-,GIP-and GLU-IR endocrine cells werefound in the intestinal mucosa of silver carp,bighead,silver crucian carp and bluntnose blackbream.Most of IR endocrine cells had the higherdistribution density in the foregut and midgut,and were longer in shape.They had a long apicalcytoplasmic process extended to the gut lumenand a basal process extended to adjacent cellsor basement membrane and touched with it.Sometimes,the basal cytoplasmic processformed an enlarged synapse-like structure in thecontiguous part with basement memb

关键词： Subject headings stomachless teleost fishes APUD cells intestinal mucosa immunocytochemistry

Impact of xenoestrogens on sex differentiation and reproduction in teleosts

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Aquaculture and Fisheries 2022年第5期7卷 562-571页

作者： Brototi Roy Reetuparna Basak Umesh Rai Department of Zoology Maitreyi CollegeUniversity of DelhiDelhi110021India Department of Zoology Bhaskaracharya College of Applied SciencesUniversity of DelhiDelhi110075India Department of Zoology University of DelhiDelhi110007India

Among vertebrates,teleosts display a wide array of sex determination and differentiation mechanisms ranging from chromosomal sex determination on one end of the spectrum to environmental sex determination on the other end.However,the interplay of both these mechanisms is also not uncommon.Several gonochoristic fishes exhibit gonadal plasticity often resulting in sex reversal.The major manipulation of sex differentiation in teleost is affected by sex steroids.In this context,the increasing contamination of aquatic ecosystems by estrogen-like compounds,commonly known as xenoestrogens,is of major concern.This often leads to deleterious effects on the reproductive success of fish and thereby adversely impacts aquatic biodiversity.In the present review,we have focused on impact of xenoestrogen at different levels of the reproductive system influencing not only gonadal differentiation in teleosts but also their reproductive functions.The review would also explore the mitigation strategies and regulations in place for aquatic xenoestrogen management.

关键词： Xenoestrogen teleost Sex differentiation Gonad Intersex Reproduction

Sexual plasticity in bony fishes:Analyzing morphological to molecular changes of sex reversal

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Aquaculture and Fisheries 2022年第5期7卷 525-539页

作者： Swathi Tenugu Balasubramanian Senthilkumaran Department of Animal Biology School of Life SciencesUniversity of HyderabadP.O.Central UniversityHyderabad500046India

Sex reversal is one of the characteristic properties of sexual plasticity in bony fishes wherein both natural and induced sex change happens at various stages of life cycle in different species.Sex determination in gonochoristic species is genetically regulated,wherein the same sex is retained throughout their life span whereas hermaphrodites change their sex during development or adulthood.In sequential hermaphrodites,serial sex change occurs at different points of life cycle.Concurrently,synchronous hermaphrodites function as both the sexes during spawning.Other variables like temperature,pH and social factors can trigger sex reversal in teleost.Sex reversal through gene mutations and chemicals/hormones,including sex steroids,can be induced mostly at early developmental stages but natural sex reversal can occur at any time.Sex reversal mechanism shows morphological to molecular changes,which are ideal for identification of sex-specific gene markers.In fact,gonadal transdifferentiation occurs at the molecular level through differential expression of transcription factors and steroidogenic enzyme genes vis-a-vis hormones,thereby imparting phenotypic or structural changes.In addition,brain shows sexual dimorphism which is mostly consequential to gonadal sex development and occasionally either causative.The major breakthrough in this line is the identification of sex determining genes such as dmy/dmrt1Yb,gsdfY,sox3 in the Japanese medaka and amhY in Patagonian pejerrey.Incidentally,the induction of mono-sex population by favouring one sex due to sex-specific differences in growth is an important economic boom for aquaculture.This review comprehensively highlights key molecular factors involved in natural and induced sex reversal conditions to illustrate teleostean sexual plasticity and its application perspectives.

关键词： Sex reversal Sequential hermaphrodite Sex steroids Gonadal transdifferentiation Sexual dimorphism teleost

Duplication and diversification of insulin genes in ray-finned fish

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Zoological Research 2019年第3期40卷 185-197页

作者： David M.Irwin Department of Laboratory Medicine and Pathobiology University of Toronto Banting and Best Diabetes Centre University of Toronto

Insulin is a key hormone for the regulation of metabolism in vertebrates.Insulin is produced by pancreatic islet cells in response to elevated glucose levels and leads to the uptake of glucose by tissues such as liver and adipose tissue to store energy.Insulin also has additional functions in regulating development.Previous work has shown that the proglucagon gene,which encodes hormones counter regulating insulin,is duplicated in teleost fish,and that the peptide hormones encoded by these genes have diversified in function.I sought to determine whether similar processes have occurred to insulin genes in these species.Searches of fish genomes revealed an unexpected diversity of insulin genes.A triplication of the insulin gene occurred at the origin of teleost fish,however one of these three genes,insc,has been lost in most teleost fish lineages.The two other insulin genes,insa and insb,have been retained but show differing levels of selective constraint suggesting that they might have diversified in function.Intriguingly,a duplicate copy of the insa gene,which I named insab,is found in many fish.The coding sequenee encoded by insab genes is under weak selective constraint,with its predicted protein sequences losing their potential to be processed into a two-peptide hormone.However,these sequences have retained perfectly conserved cystine residues,suggesting that they maintain insulin's three-dimensional structure and therefore might modulate the processing and secretion of insulin produced by the other genes.

关键词： Insulin teleost fish Gene duplicati on Adaptive evolution Gene loss