检索结果-南通市图书馆

Ultrasound-mediated targeted microbubbles： a new vehicle for cancer therapy

Frontiers of Chemical Science and Engineering 2013年第1期7卷 20-28页

作者： Junxiao YE Huining HE Junbo GONG Weibing DONG Yongzhuo HUANG Jianxin WANG Guanyi CHEN Victor C YANG School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China Department of Pharmaceutics School of Pharmacy Fudan University Key Laboratory of Smart Drug Delivery Ministry of Education & PLA Shanghai 201203 China School of Environmental Science and Engineering State Key Laboratory of Engines Tianjin University Tianjin 300072 China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of Pharmacy Tianjin Medical University Tianjin 300070 China Department of Pharmaceutical Sciences College of Pharmacy University of Michigan Ann Arbor MI 48109-1065 USA

With the hope of overcoming the serious side effects, great endeavor has been made in tumor-targeted chemotherapy, and various drug delivery modalities and drug carriers have been made to decrease systemic toxicity caused by chemotherapeutic agents. Scientists from home and abroad focus on the research of targeted microbubbles contrast agent, and the use of the targeted ultrasound microbubble contrast agent can carry gene drugs and so on to the target tissue, as well as mediated tumor cell apoptosis and tumor microvascular thrombosis block, etc., thus plays the role of targeted therapy. Recent studies have elucidated the mechanisms of drug release and absorption, however, much work remains to be done in order to develop a successful and optimal system. In this review, we summarized the continuing efforts in under-standing the usage of the ultrasound triggered target microbubbles in cancer therapy, from release mechanism to preparation methods. The latest applications of ultra-sound-triggered targeted microbubbles in cancer therapy, especially in gene therapy and antiangiogenic cancer therapy were discussed. Moreover, we concluded that as a new technology, ultrasound-triggered targeted microbubbles used as drug carriers and imaging agents are still energetic and are very likely to be translated into clinic in the near future.

关键词： ultrasound-mediated targeted microbubbles cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lymphocytes favor the attachment of CD11A-targeted microbubbles with endothelial cells in vitro

Lymphocytes favor the attachment of CD11A-targeted microbubb...

引用

2011年全国压电和声波理论及器件应用研讨会

作者： Wei YANG~1 Fei YAN~1 Juan-Juan CHEN~2 Hai-Rong ZHENG~(1,3,*) 1 Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055 2 Molecular Medicine and Cancer Research Center,Chongqing Medical University,Chongqing 400016 3 Key Lab of Health Informatics of Chinese Academy of Sciences,Shenzhen 518055

＜正＞Ultrasound molecular imaging may provide new insights into the early detection and diagnose of diseases,such as atherosclerosis,thrombosis as well as inflammations by the attachment of various targeted contrast ... 详细信息

关键词： targeted microbubbles Lymphocyte endothelial cells Adhesion

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：