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Clinical study on the changes of the tumor target volume and organs at risk in helical tomotherapy for nasopharyngeal carcinoma

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Chinese Medical Journal 2012年第1期000卷 87-90页

作者： LU Na FENG Lin-chun CAI Bo-ning HOU Jun WANG Yun-lai XIE Chuan-bin Department of Radiation Oncology People's Liberation Army General HospitalBeijing 100853China

Background Helical tomotherapy （HT） is a new image-guided intensity-modulated radiation therapy （IMRT）.The aim of this study was to evaluate the changes in the target volume and organs at risk （OARs） of patients with nasopharyngeal carcinoma （NPC） during helical *** Forty-three patients with NPC and treated via HT from March 2008 to January 2010 were reviewed *** CT scanning and plan adaptation were conducted at the 20th fraction during *** volumetric differences between the two scans were evaluated for nasopharyngeal tumor and retro- pharyngeal lymph nodes （GTVnx）,neck lymph nodes （GTVnd）,and parotid glands,as well as the axial diameter of the *** The median interval between the two scans was 25 days （23-28 days）.The volumetric decrease in GTVnx was 30.1% （median,29.8%） and in GTVnd 41.6% （median,45.9%）.The variation in the GTVnd volume was correlated with the weight loss of the *** volume of the left parotid gland decreased by 35.5% （median,33.4%） and of the right parotid glands decreased by 36.8% （median,33.5%）.The axial diameter of the head decreased by 9.39% （median,9.1%）.Conclusions The target volume and OARs of patients with NPC varied considerably during *** changes may have potential dosimetric effects on the target volume and/or OARs and influence the clinical *** CT scanning and replanning during the HT for NPC patients with a large target volume or an obvious weight loss are recommended.

关键词： nasopharyngeal carcinoma helical tomotherapy target volume organs at risk

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Dosimetry Comparison between volumetric Modulated Arc Therapy with RapidArc and Fixed Field Dynamic IMRT for Local-Regionally Advanced Nasopharyngeal Carcinoma

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Chinese Journal of Cancer Research 2011年第4期23卷 259-264页

作者： Bao-min Zheng Xiao-xia Dong Hao Wu You-jia Duan Shu-kui Han Yan Sun Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of RadiotherapyPeking University School of Oncology Beijing Cancer Hospital & Institute Beijing 100142 China

Objective: A dosimetric study was performed to evaluate the performance of volumetric modulated arc radiotherapy with RapidArc on locally advanced nasopharyngeal carcinoma (NPC). Methods: The CT scan data sets of 20 patients of locally advanced NPC were selected randomly. The plans were managed using volumetric modulated arc with RapidArc and fixed nine-field coplanar dynamic intensity-modulated radiotherapy (IMRT) for these patients. The dosimetry of the planning target volumes (PTV), the organs at risk (OARs) and the healthy tissue were evaluated. The dose prescription was set to 70 Gy to the primary tumor and 60 Gy to the clinical target volumes (CTV) in 33 fractions. Each fraction applied daily, five fractions per week. The monitor unit (MU) values and the delivery time were scored to evaluate the expected treatment efficiency. Results: Both techniques had reached clinical treatment’s requirement. The mean dose (Dmean), maximum dose (Dmax) and minimum dose (Dmin) in RapidArc and fixed field IMRT for PTV were 68.4±0.6 Gy, 74.8±0.9 Gy and 56.8±1.1 Gy; and 67.6±0.6 Gy, 73.8±0.4 Gy and 57.5±0.6 Gy (P0.05). Compared to IMRT, RapidArc allowed a reduction of Dmean to the brain stem, mandible and optic nerves of 14.1% (P<0.05), 5.6% (P<0.05) and 12.2% (P<0.05), respectively. For the healthy tissue and the whole absorbed dose, Dmean of RapidArc was reduced by 3.6% (P<0.05), and 3.7% (P<0.05), respectively. The Dmean to the parotids, the spinal cord and the lens had no statistical difference among them. The mean MU values of RapidArc and IMRT were 550 and 1,379. The mean treatment time of RapidArc and IMRT was 165 s and 447 s. Compared to IMRT, the delivery time and the MU values of RapidArc were reduced by 63% and 60%, respectively. Conclusion: For locally advanced NPC, both RapidArc and IMRT reached the c

关键词： volumetric modulated arc therapy Intensity-modulated radiotherapy Dosimetry target volume Nasopharyngeal carcinoma

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