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tako tsubo syndrome: A literature review and a case report

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World Journal of Cardiovascular Diseases 2012年第3期2卷 118-123页

作者： Francesco Bartolomucci Giuseppe Nasso Francesco Cipriani Giovanni Deluca Gianluca Sgarra Carlo D’Agostino Giuseppe Speziale Department of Cardiac Surgery Anthea Hospital GVM Care & Research Bari Italy Department of Cardiology Andria Italy Division of Cardiology Intensive Care Unit “Di Venere” Hospital Bari Italy

The tako-tsubo syndrome is a rare yet recognized condition characterized by acute but rapidly reversible left ventricular dysfunction in absence of obstructive coronary artery stenosis. Although several factors have been associated with the development of this syndrome, still its etiology remains undefined. We report the case of a 51-years-old woman presenting with dyspnea in whom the diagnosis of tako-tsubo syndrome was posed. We describe the diagnostic modalities and the clinical outcome of the patient. Secondly, the present paper is aimed at providing a review of the current evidence over this topic and at proposing future research directions.

关键词： tako-tsubo Syndrome Pathophysiology

tako-tsubo cardiomyopathy in a male patient after administration of isoproterenol and implantation of a pacemaker

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World Journal of Cardiovascular Diseases 2012年第1期2卷 38-41页

作者： Fathia Mghaieth Zghal Ramy Trabelsi Sihem Mbarki Ghassen Cherif Nidhal Ben Moussa Mohamed Sami Mourali Rachid Mechmeche 不详

Background: tako-tsubo cardiomyopathy occurs typicallly after an intrinsic adrenergic hyperstimulation triggered by a psychological or physically stressful event. Exceptionally, it may be caused by an exogenous hyperadrenergism. We report the case of an 85 year old man, hypertensive, with a history of ischemic stroke. He consulted for signs of heart failure with recurrent dizziness two weeks which was explained by an atrioventricular block. Initial echocardiography showed left ventricular ejection fraction to 60% with no wall motion abnormalities. The patient received iso-prenaline (0.02 mcg/kg/mn) for 20 hours before the implantation of a single chamber pacemaker. At 24 hours of admission an acute pulmonary edema occurred. The control echocardiography showed impaired left ventricular ejection fraction of 25% with apical ballooning and akinesis was also found on ventricu-lography. Coronary angiography showed no significant coronary lesions. Troponin level was elevated to 2 ng/ml. The pulmonary edema was then controlled. Subsequent clinical and echocardiographic were favo- rable after two weeks which was consistent with the diagnosis of tako-tsubo cardiomyopathy. Conclusion: This case illustrates an example of tako-tsubo syndrome induced by an exogenous catecholergic stimulation (isoprenaline) combined with an endogenous release after a pacemaker implantation which confirmed the physiopathological hypothesis of a catecholamine-mediated stunning in tako-tsubo cardiomyopathy.

关键词： tako-tsubo Syndrome Isoprenaline Pacemaker Left Ventricular Dysfunction Ventricular Dysfunction

tako-tsubo syndrome after administration of intravenous adrenaline during atrioventricular block

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Open Journal of Emergency Medicine 2013年第2期1卷 8-10页

作者： Manuel Calvo-Taracido Manuel Almendro-Delia Juan C. Garcia-Rubira Unidad de Gestion de Cardiologia Hospital Universitario Virgen Macarena Sevilla Spain

We describe the clinical case of a 70-year-old woman with complete atrioventricular block that after administration of intravenous adrenaline, developed electrocardiographic changes suggestive of acute coronary syndrome, together with apical dyskinesia of the left ventricle. After ruling out the existence of coronary lesions, and after total recovery of the echocardiographic alterations in segmental contractility, she was diagnosed as tako-tsubo syndrome induced by administration of adrenaline. This is the first report of this syndrome in the scenario of atrioventricular block treated with adrenaline infusion.

关键词： Adrenaline Asystole Atrioventricular Block tako-tsubo Syndrome

Heart and lung, a dangerous liaison-tako-tsubo cardiomyopathy and respiratory diseases: A systematic review

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World Journal of Cardiology 2014年第5期6卷 338-344页

作者： Roberto Manfredini Fabio Fabbian Alfredo De Giorgi Marco Pala Alessandra Mallozzi Menegatti Claudia Parisi Elisa Misurati Ruana Tiseo Massimo Gallerani Raffaella Salmi Eduardo Bossone Clinica Medica Azienda Ospedaliera-Universitaria of Ferrara 44124 Cona Ferrara Italy 1st Internal Medicine Unit Azienda Ospedaliera-Universitaria of Ferrara 44124 Cona Ferrara Italy 2nd Internal Medicine Unit Azienda Ospedaliera-Universitaria of Ferrara 44124 Cona Ferrara Italy Cardiology Unit Azienda Ospedaliera-Universitaria of Salerno 84131 Salerno Italy

AIM: To investigate the possible association between tako-tsubo cardiomyopathy(TTC)-a reversible clini-cal condition mimicking an acute myocardial infarction characterized by multifactorial pathophysiologic mecha-nisms- and respiratory system diseases. METHODS: We systematically searched PubMed and EMBASE medical information sources, to identify the different triggering causes, limiting our search to ar-ticles in English. The search keywords were: "tako-tsubo cardiomyopathy", "takotsubo", "takotsubo cardiomyopa-thy", "broken heart syndrome", "stress-induced cardio-myopathy", "apical ballooning syndrome", and "ampulla cardiomyopathy in combination with respiratory dis-eases, lung, pulmonary disease. For each kind of dis-ease, we registered: author, year and country of study, patient sex, age, concurring situation, and outcome. RESULTS: Out of a total of 1725 articles found, we se-lected 37 papers reporting a total of 38 patients. As ex-pected, most patients were women(81.6%), mean age was 65 ± 10 years. Outcome was favorable in 100% of cases, and all the patients have been discharged un-eventfully in a few days. CONCLUSION: An association between respiratory diseases and TTC is likely to exist. Patients with severe respiratory diseases, due to the high dosages of β2-agonists used or to the need of invasive procedures, are highly exposed to the risk of developing TTC.

关键词： tako-tsubo cardiomyopathy Stress cardiomyopathy Respiratory diseases Lung Chronic obstructive pulmonary disease Asthma

tako-tsubo心肌病的超声心动图表现

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临床超声医学杂志 2016年第6期18卷 428-429页

作者：魏俊涛李慧敏聂昆陆梦三峡大学第三临床医学院葛洲坝集团中心医院超声科湖北省宜昌市443002

tako-tsubo心肌病也称为应激性心肌病、伤心综合征等。该病临床表现与急性心肌梗死类似,包括应激诱发的剧烈胸痛、心电图ST段抬高、可逆性左心室功能障碍及可伴有或不伴有心肌损伤标志物升高,极易误诊。本组回顾性分析11例takotsubo心... 详细信息

tako-tsubo心肌病也称为应激性心肌病、伤心综合征等。该病临床表现与急性心肌梗死类似,包括应激诱发的剧烈胸痛、心电图ST段抬高、可逆性左心室功能障碍及可伴有或不伴有心肌损伤标志物升高,极易误诊。本组回顾性分析11例takotsubo心肌病患者的影像学资料,旨在探讨超声心动图对其的诊断价值。

关键词：心肌病 tako-tsubo 超声心动图心肌损伤标志物急性心肌梗死室壁运动左心室功能声像图剧烈胸痛应激性

典型与非典型急性心尖球囊样综合征(tako-tsubo心肌病)中的心血管磁共振发现

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世界核心医学期刊文摘（心脏病学分册） 2007年第11期3卷 46-47页

作者： Haghi D. Fluechter S. Suselbeck T. 韩瑞娟 I. Medical Department University Hospital Mannheim Mannheim Germany

入选17例行左心导管术和钆增强心血管磁共振(CMR)的tako-tsubo心肌病(TTC)连续患者(15例女性),评价在TTC中的CMR发现结果。所有患者均有异常心电图表现,包括ST段抬高(n=8)、ST段压低(n=4)、T波倒置(n=14)。1例患者出现左束支传导阻滞。

关键词：心肌病 tako-tsubo 心肌疾病磁共振心血管

tako-tsubo心肌病患者左心室功能早期改善的相关资料

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世界核心医学期刊文摘(心脏病学分册) 2007年第5期 52-52页

作者： Kurisu S. Inoue I. Kawagoe T. 马超 Hiroshima 730-8518 Japan Department of Cardiology Hiroshima City Hospital 7- 33 Moto-machi Naka-ku

1例86岁女性患者因与其女儿激烈争吵后胸痛而入住本院。心电图显示V2～V3导联ST段抬高和V3～V6导联T波倒置。胸痛发作后2h行急诊心导管插入术。冠状动脉造影显示无显著冠状动脉疾病。然而,左心室

关键词：心肌病心肌疾病 tako-tsubo 患者

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应激性心肌病的研究进展

国际心血管病杂志 2009年第2期36卷 111-115页

作者：陈千生浦晓东福建医科大学省立临床学院心血管内科 350001

应激性心肌病是临床表现为一过性类似急性心肌梗死样胸痛的综合征。心电图表现为ST段抬高、T波倒置,QT间期延长;心肌酶学可以有轻到中度升高;心脏超声表现为短暂的左室心尖-中段气球样改变,运动减弱伴基底段收缩力增强。冠状动脉造影未... 详细信息

应激性心肌病是临床表现为一过性类似急性心肌梗死样胸痛的综合征。心电图表现为ST段抬高、T波倒置,QT间期延长;心肌酶学可以有轻到中度升高;心脏超声表现为短暂的左室心尖-中段气球样改变,运动减弱伴基底段收缩力增强。冠状动脉造影未见器质性狭窄,心室造影提示收缩末期可见左室心尖-中段的心腔扩大、基底段缩窄。病因尚不清楚,大多数病人预后良好。

关键词：应激性心肌病 tako-tsubo 冠状动脉结构异常症候群

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左心室造影证实应激性心肌病一例

现代医学 2015年第1期43卷 104-106页

作者：刘涛刘宗涛武汉市第十一医院心内科湖北武汉430015

1临床资料女性患者54岁,因＂胸痛1 d＂入院。患者1 d前与人剧烈争吵后突发胸痛,呈钝痛,疼痛局限于心前区手掌大小范围,伴胸闷、恶心;无呕吐、心慌、气促、大汗;无黑蒙、晕厥;无肢体放射痛,持续约20 min后疼痛逐渐缓解,就诊当地卫生院查... 详细信息

1临床资料女性患者54岁,因＂胸痛1 d＂入院。患者1 d前与人剧烈争吵后突发胸痛,呈钝痛,疼痛局限于心前区手掌大小范围,伴胸闷、恶心;无呕吐、心慌、气促、大汗;无黑蒙、晕厥;无肢体放射痛,持续约20 min后疼痛逐渐缓解,就诊当地卫生院查心电图示＂窦性心律ST-T改变＂（发病3 h）。因胸痛缓解未接受治疗。

关键词：应激性心肌病急性心肌梗死 tako-tsubo 病例报告