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Dynamic changes in the systemic immune responses of spinal cord injury model mice

Neural Regeneration Research 2021年第2期16卷 382-387页

作者： Tian-Yun Gao Fei-Fei Huang Yuan-Yuan Xie Wen-Qing Wang Liu-Di Wang Dan Mu Yi Cui Bin Wang Clinical Stem Cell Center the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu ProvinceChina Department of Radiology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu ProvinceChina Reproductive and Genetic Center of National Research Institute for Family Planning BeijingChina

Intraspinal inflammatory and immune responses are considered to play central roles in the pathological development of spinal cord *** study aimed to decipher the dynamics of systemic immune responses,initiated by spinal cord *** spinal cord in mice was completely transected at *** in the in vivo inflammatory response,between the acute and subacute stages,were observed.A rapid decrease in C-reactive protein levels,circulating leukocytes and lymphocytes,spleen-derived CD4~+interferon-γ+T-helper cells,and inflammatory cytokines,and a marked increase in neutrophils,monocytes,and CD4~+CD25~+FOXP3~+regulatory T-cells were observed during the acute *** systemic immune alterations were gradually restored to basal levels during the sub-acute *** the acute phase of spinal cord injury,systemic immune cells and factors showed significant inhibition;however,this inhibition was transient,and the indicators of these serious disorders gradually returned to baseline levels during the subacute *** experiments were performed in accordance with the institutional animal care guidelines,approved by the Institutional Animal Care and Use Committee of Experimental Animal Center of Drum Tower Hospital,China(approval No.2019 AE01040)on June 25,2019.

关键词： C-reactive protein immune dysfunction inflammation inflammatory cytokines regulatory T-cells spinal cord injury systemic immune response T-helper cells

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