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systematic evaluation of traditional Chinese medicine for treating Parkinson's disease

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Neural Regeneration Research 2010年第8期5卷 602-610页

作者： Wanmin Chen Xinfu Lian Department of Neurology Fangcun BranchGuangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510370Guangdong ProvinceChina

BACKGROUND：To evaluate the quality of the literature addressing traditional Chinese medicine for treating Parkinson＇s *** SOURCE：A computer-based online search of Chinese publications from January 2001 to July 2008 was conducted in Chinese Biology Medical Disc Database and China National Knowledge Infrastructure. Search key words were Parkinson＇s disease, integrated traditional Chinese and Western medicine, traditional Chinese medicine therapy, and Chinese herb *** SELECTION：Articles describing randomized, controlled trials and quasi-randomized, controlled trials were included. Literature quality was assessed using the criteria-systematic evaluation of clinical literature related to treatment of Parkinson＇s disease with traditional Chinese medicine. This included methodology, interventions in the treatment/control group, evaluation criterion of outcomes, and *** OUTCOME MEASURES：evaluation criterion of outcomes （various score methods and evaluation scales）, methodological quality, and frequency distribution were all ***：A total of 33 articles with randomized, controlled trials were included. Of these, six described a random method, and the remaining did not describe random allocation methods or random sequence generation methods. None of the studies estimated sample size. Case descriptions of withdrawal and loss to follow-up were unclear. Both the Unified Parkinson＇s Disease Rating Scale and Webster scale were used in the eligible studies as evaluation ***：There are no high-quality studies that address traditional Chinese medicine therapy and integrated traditional Chinese and Western medicine for treating Parkinson＇s disease in China. Eligible studies were not performed in accordance with Consolidated Standards of Reporting Trials statement or Standards for Reporting Interventions in Controlled Trials of Acupuncture criteria, and the literature quality was low. The presently used criteria for evaluating ther

关键词： traditional Chinese medicine Parkinson's disease literature review systematic evaluation neurodegenerative disease neural regeneration

systematic evaluation of Guidelines for the Diagnosis and Treatment of Hepatitis E Virus Infection

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Journal of Clinical and Translational Hepatology 2024年第8期12卷 739-749页

作者： Ting Gu Cai-Ying Zheng Yan-Qin Deng Xiao-Feng Yang Wei-Min Bao Ying-Mei Tang Department of Gastroenterology Second Affiliated Hospital of Kunming Medical UniversityKunming Medical UniversityKunmingYunnanChina Second Affiliated Hospital of Kunming Medical University KunmingYunnanChina Department of Colorectal Surgery The First People’s Hospital of Yunnan ProvinceKunmingYunnanChina

Background and Aims:The hepatitis E virus(HEV)is a zoonotic disease,and infection with HEV in humans primarily causes acute infections and can progress to chronic manifestation in immunocompromised *** the past decade,guidelines for diagnosing and treating HEV infection have been *** study aimed to systematically assess the quality of current guidelines for diagnosing and treating HEV infection,and we analyzed the differences in guideline quality and primary recommendations and explored possible reasons for these ***:Guidelines published between 2013 and 2022 were searched,and studies were identified using selection *** study assessed the quality of the included guidelines using the Appraisal of Guidelines for Research and evaluation tool,extracted the primary recommendations in the guidelines,determined the highest level of evidence supporting the recommendations,and reclassified the evidence using the Oxford Centre for Evidence-Based Medicine grading ***:Seven guidelines were included in the final *** quality of the guidelines varied *** discrepancies may have been caused by the lack of external experts,the failure to consider influencing factors in guideline application,and the lack of consideration of the public’s *** of the heterogeneity in primary recommendations revealed differences in algorithms for managing chronic HEV infection,the dosage of ribavirin,and a low level of evidence supporting the primary ***:Guideline quality and primary recommendations vary *** by guideline developers and researchers would facilitate updating and applying guidelines for diagnosing and treating HEV infection.

关键词： Hepatitis E virus Guidelines Diagnosis Treatment systematic evaluation

systematic evaluation and Meta-analysis of acupuncture and collaterals cupping therapy for Knee Osteoarthritis

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TMR Modern Herbal Medicine 2019年第1期2卷 36-47页

作者： Li-Hui Zhang Yong-Chen Zhao College of Chinese Medicine Hebei UniversityBaodingHebeiChina Affiliated Hospital of Hebei university BaodingHebeiChina

Objective:In order to obtain the best treatment program for Knee Osteoarthritis(KOA),to alleviate the pain of patients with KOA,and to systematically evaluate the efficacy of acupuncture cupping therapy for ***:we used computer to search the databases of CNKI(1989-2018.10),Wanfang(1989-2018.10),VIP(1989-2018.10),PubMed(1966-2018.10),EMbase(1986-2018.10)and Cochrane Library(the 3rd issue of 2018).And the literature quality was evaluated by Jadad ***:A total of 19 eligible RCT studies were included,and a total of 2,088 patients participated in the eligible clinical ***-analysis results showed that the total effective rate OR combination=2.85[OR=3.98,95%CI(2.98,5.32),P<0.00001].The results showed that the curative effect of acupuncture and collaterals cupping in the treatment of KOA was superior to other ***:Acupuncture and cupping therapy of traditional Chinese medicine is effective and safe in treating *** to the impact of the original study on Meta-analysis results,more large samples and high-quality clinical trials are still needed to verify.

关键词： acupuncture and collaterals cupping therapy Traditional Chinese Medicine Knee Osteoarthritis Meta-analysis systematic evaluation

systematic evaluation of the efficacy and safety of botulinum toxin type A in the treatment of spastic cerebral palsy

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Life Research 2023年第2期6卷 10-19页

作者： Yu Jiang Gang Liu Jing-Pei Ren Yi Zhao Hui-Zhong Bai Tuo Zhao Lin Xu Xiao-Hong Mu Department of Orthopedics Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100010China

Background:Botulinum toxin type A(BTX-A)is a neuromuscular blocking ***-A inhibits acetylcholine release,causes neuromuscular transmission impairment,and decreases muscle ***:To explore the efficacy and safety of BTX-A injection in the treatment of spastic cerebral palsy through systematic evaluation and to provide a reference for the clinical use of ***:We used“Cerebral palsy”and“BTX-A”as the subject terms and used a combination of subject terms and free words for the *** searched 7 databases,including CNKI,Wanfang,VIP,Sinomed,PubMed,Embase,and Web of *** on the inclusion and exclusion criteria,we screened the articles by reading their titles,abstracts,and full texts and finally included relevant literature for systematic ***:A total of 93 papers were systematically evaluated,revealing that BTX-A injection treatment can effectively reduce muscle tone,increase joint mobility,improve gait and motor posture,and enhance gross motor movements in patients with spastic cerebral *** benefits of BTX-A treatment can be sustained for 3–6 months,with motor ability improvement lasting up to 1 *** BTX-A treatment with rehabilitation or external fixation therapy can enhance its ***,the effectiveness of BTX-A treatment is influenced by several factors,such as the dosage,number of injections,and patient *** reactions to BTX-A treatment are typically mild and can be relieved within 1–2 ***:BTX-A injection is relatively safe but reversible.

关键词： spastic cerebral palsy botulinum toxin type A systematic evaluation

systematic evaluation on the clinical efficacy of acupoint stimulation therapy for treatment of premature ovarian insufficiency on the basis of network Meta-analysis

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World Journal of Acupuncture-Moxibustion 2017年第3期27卷 26-39页

作者： YANG Hui-sheng FANG Yi-gong XU Huan-fang LI Xiao-tong SHANG Jie YIN Ya-qian Institute of Acupuncture and Moxibustion of China Academy of Chinese Medical Sciences Acupuncture and Moxibustion Hospital of China Academy of Chinese Medical Science

Objective To systematically evaluate the effectiveness and safety of acupoint stimulation therapy for treatment of premature ovarian insufficiency（POI）. Methods Computer retrieval was carried out in such databases as Pub Med, Embase, Cochrane Library, web of science, Chinese biomedicine database（CBM）, China National Knowledge Infrastructure（CNKI）, Wan Fang and VIP in order to collect the randomized controlled trials（RCT） concerning acupoint stimulation therapy for treatment of POI. Software R 3.40 and stata 14.0 were used for Meta-analysis and network Meta-analysis, and Rev Man 5.3 was used for plotting the risk bias diagrams. Results Fortythree RCTs were included in total, involving 3046 POI patients and 18 acupoint stimulation therapies and comprehensive therapies. Metaanalysis showed：（1） The curative effects of acupoint stimulation therapy（RR=1.25, 95%CI [1.07,1.45]）, acupoint stimulation therapy＋Chinese herbal medicine（RR=1.25, 95%CI [1.18,1.32]） and acupoint stimulation therapy＋ hormone replacement therapy（HRT）（RR=1.20, 95%CI [1.12,1.29]） were all superior to that of HRT, indicating that the differences were statistically significant（Z=2.90, P=0.04; Z=7.56, P〈0.000 01; Z=4.06, P〈0.000 01）.（2） Compared with HRT, the occurrence rate of adverse effect of acupoint stimulation therapy was lower, and the safety was superior to that of HRT（RR=0.18, 95%CI [0.08,0.41]）, indicating that the differences were statistically significant（Z=4.08, P〈0.000 1）. Forty-two direct comparisons and 110 indirect comparisons were generated according to network Meta-analysis, among which, 38 comparisons were statistically significant. Network Metaanalysis results with HRT as control showed： the therapeutic measures ranking top 3 according to the curative effect sequence were catgut embedment in acupoint, moxibustion and warming-needle moxibustion, successively, and all the 3 measures were monotherapies without reflecting the advantages of comprehensive therapy. HRT ranked 17 th among the

关键词： acupoint stimulation therapy premature ovarian insufficiency clinical efficacy network Meta-analysis systematic evaluation

systematic evaluation and Meta-analysis on the Efficacy and Safety of Qidongyixin Oral Liquid(芪冬颐心口服液)in the Treatment of Coronary Heart Disease

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World Journal of Integrated Traditional and Western Medicine 2021年第5期7卷 13-23页

作者： XI Jun-yu LYU Jian XIE Yan-ming Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China

Objective:To systematically evaluate the efficacy and safety of Qidongyixin Oral Liquid(芪冬颐心口服液)in the treatment of coronary heart ***:Randomized controlled trials(RCTs)on the treatment of coronary heart disease(CHD)with Qidongyixin Oral Liquid(芪冬颐心口服液)were screened out by systematically searching in CNKI,Wanfang Data,VIP,Sinomed,Cochrane Library,PubMed,Embase,Web of Science,***-analysis of the final included studies was performed according to RevMan 5.3 ***:A total of 9 studies were included,with a total sample size of 1224 cases,including 612 in the experimental group and 612 in the control *** results showed that:Conventional treatment,combined with Qidongyixin Oral Liquid(芪冬颐心口服液)on the treatment of CHD had a significant efficiency,which was better than conventional treatment only(RR=1.18,95%CI[1.07-1.29],P=0.0005),and could better improve patients’electrocardiogram(RR=1.21,95%CI[1.08,1.35],P=0.001),increase left ventricle ejection fraction(MD=3.84,95%CI[3.34,4.33],P<0.00001),and reduce left ventricular end-diastolic diameter(MD=-2.81,95%CI[-3.84,-2.41],P<0.00001)and left ventricular end-systolic diameter(MD=-2.43,95%CI[-3.42,-1.43],P<0.00001).Conclusion:Qidongyixin Oral Liquid(芪冬颐心口服液)can improve the effective rate of the treatment of coronary heart disease,better improve patients’electrocardiogram,reduce the left ventricular end-diastolic and end-systolic diameter,and reduce the onset time of angina ***,the quality of the cases included in the study is relatively small,and the level of evidence is ***,RCT with large samples and rigorous design is still needed to prove the reliability of the results.

关键词： Qidongyixin Oral Liquid(芪冬颐心口服液) Coronary heart disease(CHD) Randomized controlled trials systematic evaluation Meta-analysis

systematic evaluation (Meta-analysis) of the Efficacy and Safety of Pudilan Xiaoyan Oral Liquid (蒲地蓝消炎口服液) in the Treatment of Suppurutive Tonsillitis in Children

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World Journal of Integrated Traditional and Western Medicine 2020年第2期6卷 26-38页

作者： DU Ying LV Jian SUN Meng-hua XIE Yan-ming Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China

To systematically evaluate the efficacy and safety of Pudilan Xiaoyan Oral in Liquid(蒲地蓝消炎口服液)in the treatment of suppurative tonsillitis in *** WanFang,CNKI,VIP,CBM,PubMed,Embase and Corchrane and other databases,relevant literatures about Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液)in the treatment of pediatric suppurative tonsillitis were *** retrieval time was from the establishment of the database to April *** randomized controlled trials were *** control group was treated with conventional antibiotics,and the observation group was treated with Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液)based on the control *** they were summarized and analyzed,Cochrane Handbook 5.1 evaluation standard and RevMan 5.3 software were used to determine the quality of literature.A total of 172 literatures were retrieved and 23 randomized controlled trials were included.A total of 1188 children were in the experimental group while 1175 children were in the control group,involving 2363 children with suppurative ***-analysis showed that the total effective rate of Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液)combined with routine treatment was better than that of routine treatment(RR=0.88,95%CI(0.86,0.91),P<0.00001);Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液)combined with routine treatment in children was better than that of routine treatment alone in term of temperature recovery,sore throat time,the reduction of tonsil purulent *** were few reports of adverse reactions and no serious adverse *** sum up,Pudilan Xiaoyan Oral Liquid(蒲地蓝消炎口服液)combined with routine treatment can significantly improve the efficacy of children with suppurative tonsillitis,but due to the low quality of the included literature,it should be used *** is suggested that clinical randomized controlled trials should be designed with large sample size,multi-centers and conforming to international standards to improve the quality of evidence.

关键词： Pudilan Tonsillitis Randomized controlled trials systematic evaluation Meta-analysis

Efficacy and safety of Yangxinshi tablet for chronic heart failure:A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第13期12卷 2218-2230页

作者： Sheng-Hua Lu Yun-Feng Yu Si-Si Dai Ya-Qi Hu Jian-He Liu The First Clinical College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Branch of National Clinical Research Center for Chinese Medicine Cardiology The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACKGROUND The specific benefits of Yangxinshi tablet(YXST)in the treating chronic heart failure(CHF)remain *** To systematically evaluate the efficacy and safety of YXST in the treatment of *** Randomized controlled trials(RCTs)investigating YXST for CHF treatment were retrieved from eight public databases up to November ***-analyses of the included clinical studies were conducted using Review Manager *** Twenty RCTs and 1845 patients were *** meta-analysis results showed that the YXST combination group,compared to the conventional drug group,significantly increased the clinical efficacy rate by 23%[relative risk(RR)=1.23,95%CI:1.17-1.29],(P<0.00001),left ventricular ejection fraction by 6.69%[mean difference(MD)=6.69,95%CI:4.42-8.95,P<0.00001]and 6-min walk test by 49.82 m(MD=49.82,95%C:38.84-60.80,P<0.00001),and reduced N-terminal pro-Btype natriuretic peptide by 1.03 ng/L[standardized MD(SMD)=-1.03,95%CI:-1.32 to-0.74,P<0.00001],brain natriuretic peptide by 80.95 ng/L(MD=-80.95,95%CI:-143.31 to-18.59,P=0.01),left ventricular end-diastolic diameter by 3.92 mm(MD=-3.92,95%CI:-5.06 to-2.78,P<0.00001),and left ventricular endsystolic diameter by 4.34 mm(MD=-4.34,95%CI:-6.22 to-2.47,P<0.00001).Regarding safety,neither group reported any serious adverse events during treatment(RR=0.54,95%CI:0.15-1.90,P=0.33).In addition,Egger's test results indicated no significant publication bias(P=0.557).CONCLUSION YXST effectively improves clinical symptoms and cardiac function in patients with CHF while maintaining a favorable safety profile,suggesting its potential as a therapeutic strategy for CHF.

关键词： Yangxinshi tablet Chronic heart failure Cardiac function systematic evaluation Meta-analysis

Effectiveness of platelet-rich plasma in the treatment of Achilles tendon disease

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World Journal of Orthopedics 2023年第6期14卷 485-501页

作者： Dan Huang Djandan Tadum Arthur Vithran Hao-Li Gong Ming Zeng Zhong-Wen Tang Zhou-Zhou Rao Jie Wen Sheng Xiao Department of Pediatric Orthopedics Hunan Provincial People’s HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina Department of Orthopaedics Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina Department of Physiology Hunan Normal University School of MedicineChangsha 410005Hunan ProvinceChina Department of Anatomy Hunan Normal University School of MedicineChangsha 410005Hunan ProvinceChina

BACKGROUND The effectiveness of Platelet-Rich Plasma(PRP)in the treatment of patients with Achilles tendon rupture(ATR)and Achilles tendinopathy(AT)has been *** To assess PRP injections’effectiveness in treating ATR and *** A comprehensive review of relevant literature was conducted utilizing multiple databases such as Cochrane Library,PubMed,Web of Science,Chinese Science and Technology Journal,EMBASE,and China Biomedical *** present investigation integrated randomized controlled trials that assessed the effectiveness of platelet-rich plasma injections in managing individuals with Achilles tendon rupture and *** eligibility criteria for the trials encompassed publications that were published within the timeframe of January 1,1966 to December *** statistical analysis was performed utilizing the Review Manager 5.4.1,the visual analogue scale(VAS),Victorian Institute Ankle Function Scale(VISA-A),and Achilles Tendon Thickness were used to assess *** This meta-analysis included 13 randomized controlled trials,8 of which were randomized controlled trials of PRP for AT and 5 of which were randomized controlled trials of PRP for *** for AT at 6 wk[weighted mean difference(WMD)=1.92,95%CI:-0.54 to 4.38,I2=34%],at 3 mo[WMD=0.20,95%CI:-2.65 to 3.05,I2=60%],and 6 mo[WMD=2.75,95%CI:-2.76 to 8.26,I2=87%)after which there was no significant difference in VISA-A scores between the PRP and control *** was no significant difference in VAS scores between the PRP group and the control group after 6 wk[WMD=6.75,95%CI:-6.12 to 19.62,I2=69%]and 6 mo[WMD=10.46,95%CI:-2.44 to 23.37,I2=69%]of treatment,and at mid-treatment at 3 mo[WMD=11.30,95%CI:7.33 to 15.27,I2=0%]after mid-treatment,the PRP group demonstrated better outcomes than the control ***-treatment patient satisfaction[WMD=1.07,95%CI:0.84 to 1.35,I2=0%],Achilles tendon thickness[WMD=0.34,95%CI:-0.04 to 0.71,I2=61%]and return to sport[WMD=1.11,95%CI:0.87

关键词： Platelet-Rich plasma Achilles tendon rupture Achilles tendinopathy systematic evaluation Randomized controlled trial