检索结果-南通市图书馆

Late-stage modification of bioactive compounds:Improving druggability through efficient molecular editing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第3期14卷 1030-1076页

作者： Tongyu Huo Xinyi Zhao Zengrui Cheng Jialiang Wei Minghui Zhu Xiaodong Dou Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Changping Laboratory Beijing 102206China Shanghai Key Laboratory of Green chemistry and Chemical Processes East China Normal UniversityShanghai 200062China

synthetic chemistry plays an indispensable role in drug discovery,contributing to hit compounds identification,lead compounds optimization,candidate drugs preparation,and so *** Nobel Prize laureate James Black emphasized,“the most fruitful basis for the discovery of a new drug is to start with an old drug”***-stage modification or functionalization of drugs,natural products and bioactive compounds have garnered significant interest due to its ability to introduce diverse elements into bioactive compounds *** modifications alter the chemical space and physiochemical properties of these compounds,ultimately influencing their potency and *** enrich a toolbox of chemical modification methods for drug discovery,this review focuses on the incorporation of halogen,oxygen,and nitrogen—the ubiquitous elements in pharmacophore components of the marketed drugs—through late-stage modification in recent two decades,and discusses the state and challenges faced in these *** also emphasize that increasing cooperation between chemists and pharmacists may be conducive to the rapid discovery of new activities of the functionalized ***,we hope this review would serve as a valuable resource,facilitating the application of late-stage modification in the construction of novel molecules and inspiring innovative concepts for designing and building new drugs.

关键词： Late-stage modification Drug space Halogenation Oxygenation Nitrogenation synthetic chemistry

维普期刊数据库

Synthesis and Characterization of Tb^(3+)-Trimesic Acid Fluorescence System

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2003年第S1期21卷 45-48页

作者：任慧娟洪广言宋心远刘桂霞刘丽娟 School of chemistry and Chemical Engineering Donghua University Key Laboratory of Rare Earth chemistry and Physics Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Institute of Technology

The luminescent complex of Tb (3+)-trimesic acid was synthesized in an alcohol and water mixed solvent. The chemical components of the complex TbL·5H_2O was characterized by the element analysis,thermal analysis and FTIR. The results of the XRD patterns and SEM photographs indicate that the complex is composed of a lot of bar-shaped crystal grain with 5～10 μm long. The results of the photoluminescence show that the complex emitted the characteristic green fluorescence of Tb (3+).

关键词： synthetic chemistry Tb(3+)-trimesic acid preciptation method luminescence complex rare earths

维普期刊数据库

A universal strategy for fast,scalable,and aqueous synthesis of multicomponent palladium alloy ultrathin nanowires

在线全文

学校读者我要写书评

暂无评论

Science China chemistry 2021年第2期64卷 245-252页

作者： Hao Lv Xuwen Guo Lizhi Sun Dongdong Xu Ben Liu College of chemistry Sichuan UniversityChengdu 610064China Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China

Noble metal alloy nanowires(NWs)with ultrathin diameters(2–3 nm)and precisely controllable elemental compositions have attracted dramatically growing attention for(electro)*** numerous achievements in past two decades,noble metal alloy NWs are mostly synthesized with the traditional oil-phase methods that suffer from some undesirable ***,we report a general strategy for fast,scalable,and aqueous synthesis of multicomponent Pd-based alloy ultrathin NWs with an average diameter of 2.6 nm,ranging from bimetallic PdM(PdFe,PdCo,PdNi,PdCu,PdZn,PdRu,PdRh,PdAg,PdCd,PdIr,PdPt,PdAu)and binary PdS/PdP NWs,to trimetallic PdM1M2 NWs(PdAuCu,PdCoNi,PdCuZn,PdCuNi,PdAgCu,PdAuCu,PdRuAg,PdAuRu,and PdPtAu),and to tetrametallic PdM1M2M3 NWs(PdAuAgCu,PdCoCuNi,PdAuCuNi,PdPtAuCu,and PdIrPtAu).The key to the success of this aqueous synthesis is the utilization of N2H4 as the extremely strong reducing agent that directs the synchronous reduction and anisotropic nucleation growth of multicomponent Pd alloy NWs along nanoconfined columnar phase assembled with amphiphilic dioctadecyldimethylammonium ***-resultant Pd-based alloy ultrathin NWs exhibit multiple structural and compositional synergies,which remarkably optimize the removal of poisoning ethoxy intermediates and thus improve electrocatalytic performance towards ethanol oxidation reaction(EOR).Among them,tetrametallic PdAuCuNi alloy ultrathin NWs hold a high EOR activity of 5.14 A mg-1 Pd and a low activation energy of 13.1 kJ mol^-1,both of which are much better than its counterpart catalysts alloyed with less *** work represents an important advance in precise aqueous synthesis of multicomponent noble metal alloy ultrathin NWs as the high-performance electrocatalysts for various targeted applications.

关键词： ultrathin nanowires multicomponent alloys palladium synthetic chemistry ethanol oxidation reaction

维普期刊数据库

Synthesizing Our Future

在线全文

学校读者我要写书评

暂无评论

Bulletin of the Chinese Academy of Sciences 2011年第1期25卷 19-27页

作者： HUANG Shao-Xu and DING Kuiling director(Shanghai Institute of Organic chemistry,CAS,Shanghai 200032,China) Shanghai Institute of Organic chemistry CAS Shanghai 200032 China

chemistry has a central role in science,and synthesis plays an essential role in chemistry. synthetic substances and materials have demonstrated a significant impact in determining the quality of our life in the last century. Although chemical synthesis has now reached an extraordinary level of sophistication,there is still vast room for improvement. In this century,to be more tightly merged with other fields such as material and life sciences,to generate more interdisciplinary areas,is an inevitable trend in synthetic chemistry. Nowadays,synthetic chemistry should pursue "GREEN" process. In this context,the atom economy,the E-factor and 3Rs (reduction,recycling and reuse) of resources must be taken into account in synthetic industry. The greatest challenge of synthetic chemistry,not only,will be immense responsibility to tackle a range of existing or predicted social and global issues associated with resources,energy,materials,the environment,food and health,but also the redeeming the negative impression of synthetic chemistry in public.

关键词： synthetic chemistry green chemistry material science life science medicine