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Value of Contrast-enhanced Ultrasound in Evaluating Synovitis and Predicting Recurrent Joint Bleeding of Hemophilia

Current Medical Science 2022年第2期42卷 439-446页

作者： Fei MA Ya-ru ZHANG Koon Hung LUKE Hao LIU Wan-xian LUO Li ZHANG Li-ling XIAO Mei YI Yang GAO Wei-zhen WANG Shi-qiu QIU Xiao-qin FENG Jing SUN Ying-jia LI Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhou510515China Hematology and Lab Medicine Divisions Children Hospital of Eastern OntarioOttawaK1H 8L1Canada Department of Ultrasound The Second People’s Hospital of ShenzhenShenzhen518025China Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhou510515China Department of Pediatrics Nanfang HospitalSouthern Medical UniversityGuangzhou510515China

Objective Contrast-enhanced ultrasound(CEUS)is advantageous for evaluating microcirculation,and has been applied to assess arthritis in previous ***,CEUS examinations have not been studied for hemophilia *** arthritis is different from other arthritis,because it is induced by spontaneous joint ***,CEUS may have special value in evaluating hemophilia *** present study assessed the value of CEUS in evaluating synovial hypertrophy and predicting recurrent joint bleeding in severe hemophilia A *** From August 2016 to January 2017,81 severe hemophilia A patients,who were referred to our hospital for ultrasound joint assessment with conventional ultrasound,were *** these 81 patients,46 patients consented for CEUS examinations on the same *** Compared to color Doppler flow imaging(CDFI),four more joints presented with a blood flow signal under CEUS *** addition,the synovial hypertrophy measured by CEUS was thicker than that measured by conventional *** ultrasound scores(including the total grey-scale ultrasound score,joint effusion/hemarthrosis,synovial hypertrophy,CDFI semi-quantitative score,and CEUS semi-quantitative score)were significantly higher in the joint bleeding group than in the no joint bleeding group(Psynovial hypertrophy and vascularization,and diagnose synovitis,when compared to conventional *** addition,CEUS appears to be essential for evaluating the possibility of recurrent joint bleeding,and providing more reliable evidence for individualized treatment.

关键词： contrast-enhanced ultrasound hemophilia arthropathy synovial hypertrophy synovial vascularity

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